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奎诺卡星

奎诺卡星

CAS号：84573-33-1

英文名：Quinocarcin

分子式

C18H22N2O4

熔点

密度

1.41g/cm3

分子量

330.378

沸点

521.3ºC at 760 mmHg

溶解度

信号词

危险品标志

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基本信息

中文名称

奎诺卡星

英文名称

Quinocarcin

中文别名

英文别名

(-)-quinocarcin、Antibiotic DC 52、DC 52

CAS号

84573-33-1

分子式

C18H22N2O4

分子量

330.378

精确质量

330.158

PSA

62.24

LOGP

0.9822

物化性质

密度

1.41g/cm3

沸点

521.3ºC at 760 mmHg

闪点

269.1ºC

折射率

1.665

合成路线

(-)-quinocarcinamide formate

(-)-quinocarcinamide formate

奎诺卡星

上游原料

共找到56个上游原料 >

(2-{(R)-1-[(1R,5S,6R)-6-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-8-methyl-2,4-dioxo-3,8-diaza-bicyclo[3.2.1]oct-3-yl]-2-methoxymethoxy-ethyl}-3-methoxy-benzyl)-triphenyl-phosphonium; bromide

(2-{(R)-1-[(1R,5S,6R)-6-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-8-methyl-2,4-dioxo-3,8-diaza-bicyclo[3.2.1]oct-3-yl]-2-methoxymethoxy-ethyl}-3-methoxy-benzyl)-triphenyl-phosphonium; bromide

<5R-(5α,8β,10β(3aR*,6S*,7aS*),11β,11aβ)>-hexahydro-8,8-dimethyl-1-<<5,7,8,9,10,11,11a,12-octahydro-4-methoxy-5-<(methoxymethoxy)methyl>-13-methyl-7-oxo-8,11-iminoazepino<1,2-b>isoquinoline-10-yl>carbonyl>-2,2-dioxo-3H-3a,6-methano-2,1-benzis.

<5R-(5α,8β,10β(3aR*,6S*,7aS*),11β,11aβ)>-hexahydro-8,8-dimethyl-1-<<5,7,8,9,10,11,11a,12-octahydro-4-methoxy-5-<(methoxymethoxy)methyl>-13-methyl-7-oxo-8,11-iminoazepino<1,2-b>isoquinoline-10-yl>carbonyl>-2,2-dioxo-3H-3a,6-methano-2,1-benzis.

(2S,4R,5R)-dimethyl 5-ethynyl-1-methylpyrrolidine-2,4-dicarboxylate

(2S,4R,5R)-dimethyl 5-ethynyl-1-methylpyrrolidine-2,4-dicarboxylate

(3S,5R)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-3-(prop-2-yn-1-yl)dihydrofuran-2-(3H)-one

(3S,5R)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-3-(prop-2-yn-1-yl)dihydrofuran-2-(3H)-one

[5R-(5α,8β,10β,11β,11aβ)]-(-)-5,7,8,9,10,11,11a,12-octahydro-4-methoxy-5-[(methoxymethoxy)methyl]-13-methyl-7-oxo-8,11-iminoazepino[1,2-b]isoquinoline-10-carboxylic acid

[5R-(5α,8β,10β,11β,11aβ)]-(-)-5,7,8,9,10,11,11a,12-octahydro-4-methoxy-5-[(methoxymethoxy)methyl]-13-methyl-7-oxo-8,11-iminoazepino[1,2-b]isoquinoline-10-carboxylic acid

Dx 52-1

上游原料

(2-{(R)-1-[(1R,5S,6R)-6-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]decane-4-carbonyl)-8-methyl-2,4-dioxo-3,8-diaza-bicyclo[3.2.1]oct-3-yl]-2-methoxymethoxy-ethyl}-3-methoxy-benzyl)-triphenyl-phosphonium; bromide <5R-(5α,8β,10β(3aR*,6S*,7aS*),11β,11aβ)>-hexahydro-8,8-dimethyl-1-<<5,7,8,9,10,11,11a,12-octahydro-4-methoxy-5-<(methoxymethoxy)methyl>-13-methyl-7-oxo-8,11-iminoazepino<1,2-b>isoquinoline-10-yl>carbonyl>-2,2-dioxo-3H-3a,6-methano-2,1-benzis. (2S,4R,5R)-dimethyl 5-ethynyl-1-methylpyrrolidine-2,4-dicarboxylate (3S,5R)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-3-(prop-2-yn-1-yl)dihydrofuran-2-(3H)-one [5R-(5α,8β,10β,11β,11aβ)]-(-)-5,7,8,9,10,11,11a,12-octahydro-4-methoxy-5-[(methoxymethoxy)methyl]-13-methyl-7-oxo-8,11-iminoazepino[1,2-b]isoquinoline-10-carboxylic acid Dx 52-1 2-[(4S,5R)-5-hydroxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl]-3-methylanisole (R)-[2-azido-2-(2-fluoro-6-iodophenyl)ethoxy](tert-butyl)dimethylsilane (S)-1-(2-fluoro-6-iodophenyl)ethane-1,2-diol (2S,4R,5R)-dimethyl 5-ethynyl-1-tosylpyrrolidine-2,4-dicarboxylate 2-溴-1-甲氧基-3-甲基苯 (-)-quinocarcinamide 2-氟-6-碘苯甲醛 (R)-γ-羟甲基-γ-丁内酯 (R)-4,5-二氢-5-羟甲基-2(3H)-呋喃酮 (R)-5-羟甲基-2-氧代四氢呋喃 7-cyanoquinocarcinol (3aR-(1(1S*,3(R*),5R*,6R*),3aα,6α,7aβ))-1-((3-(2-hydroxy-1-(2-methoxy-6-methylphenyl)ethyl)-8-methyl-2,4-dioxo-3,8-diazabicyclo(3.2.1)oct-6-yl)carbonyl)hexahydro-8,8-dimethyl-2,2-dioxo-3H-3a,6-methano-2,1-benzisothiazole (S)-2-{(R)-3-[(tert-butyldiphenylsilyl)oxy]-2-hydroxypropyl}pent-4-yn-1-yl acetate (1R,3R)-2,2,2-trichloroethyl 3-((2R,3R,5S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-3-methoxymethoxymethylpyrrolidin-2-yl)-1-hydroxymethyl-8-methoxy-3,4-dihydro-2(1H)-isoquinolinecarboxylate (1R,3R)-2,2,2-trichloroethyl 3-<(2R,3R,5S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-3-methoxymethoxymethylpyrrolidin-2-yl>-1-<(4R,5R)-5-methoxymethoxymethyl-2,2-dimethyl-1,3-dioxolan-4-yl>-8-methoxy-3,4-dihydro-2(1H)-isoquinolinecarboxylate ((2R,3R,5S)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-2-ethynyl-1-tosylpyrrolidin-3-yl)methyl acetate (5R,8S,10R,11R,11aS)-methyl 5-(chloromethyl)-4-methoxy-13-methyl-7-oxo-5,7,8,9,10,11,11a,12-octahydro-8,11-epiminoazepino[1,2-b]isoquinoline-10-carboxylate <5R-(5α,8β,10β(3aR*,6S*,7aS*),11β)>-1-<<5,7,8,9,10,11-hexahydro-4-methoxy-5-<(methoxymethoxy)methyl>-13-methyl-7-oxo-8,11-iminoazepino<1,2b>isoquinoline-10-yl>carbonyl>hexahydro-8,8-dimethyl-2,2-dioxo-3H-3a,6-methano-2,1-benzisothiazole (1R,3R)-2,2,2-trichloroethyl 1-acetoxymethyl-3-[(2R,3R,5S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-3-methoxymethoxymethylpyrrolidin-2-yl]-8-methoxy-3,4-dihydro-2(1H)-isoquinolinecarboxylate (R)-2-azido-2-(2-fluoro-6-iodophenyl)ethanol (2S,4R)-5-[(tert-butyldiphenylsilyl)oxy]-2-(prop-2-yn-1-yl)pentane-1,4-diol 3-((2R,3R,5S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-3-methoxymethoxymethylpyrrolidin-2-yl)-1-((4R,5R)-5-methoxymethoxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl)-8-methoxyisoquinoline (5R,7R,8S,10R,11R,11aS)-5-acetoxymethyl-7-cyano-10-hydroxymethyl-4-methoxy-13-methyl-5,7,8,9,10,11,11a,12-octahydro-8,11-iminoazepino<1,2-b>isoquinoline (2R,3R,5S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-2-[2-[(4S,5R)-5-methoxymethoxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl]acetyl]-3-methoxymethoxymethylpyrrolidine 5-(1-diphenylsilyloxy-2,2-dimethylpropyl)oxolan-2-one 2-<(4R,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole (5R,7R,8S,10R,11R,11aS)-5-acetoxymethyl-7-cyano-10-hydroxymethyl-4-methoxy-5,7,8,9,10,11,11a,12-octahydro-8,11-iminoazepino[1,2-b]isoquinoline 2-<(4S,5R)-5-methoxymethoxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole (1R,5S,6R)-3-((R)-1-(2-(bromomethyl)-6-methoxyphenyl)-2-(methoxymethoxy)ethyl)-6-((3aR,6S,7aS)-8,8-dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazole-1-carbonyl)-8-methyl-3,8-diazabicyclo[3.2.1]octane-2,4-dione (5R,7R,8S,10R,11R,11aS)-5-acetoxymethyl-13-tert-butoxycarbonyl-7-cyano-4-methoxy-10-methoxymethoxymethyl-5,7,8,9,10,11,11a,12-octahydro-8,11-iminoazepino(1,2-b)isoquinoline (S)-2-[(tert-butyldimethylsilyl)oxy]-1-(2-fluoro-6-iodophenyl)ethanol (5R-(5α,7β,8β,10β,11β,11aβ))-7-cyano-5,7,8,9,10,11,11a,12-octahydro-4-methoxy-5-[(methoxymethoxy)methyl]-13-methyl-8,11-iminoazepino[1,2-b]isoquinoline-10-carboxylic acid (-)-quinocarcinamide formate (5R,8S,10R,11R,11aS)-methyl 5-(hydroxymethyl)-4-methoxy-13-methyl-7-oxo-5,7,8,9,10,11,11a,12-octahydro-8,11-epiminoazepino[1,2-b]isoquinoline-10-carboxylate (5R,10R,11aS)-7-cyano-4-methoxy-5-((methoxymethoxy)methyl)-13-methyl-5,7,8,9,10,11,11a,12-octahydro-8,11-epiminoazepino[1,2-b]isoquinoline-10-carboxylic acid (1R,3R)-2,2,2-trichloroethyl 1-acetoxymethyl-3-<(2R,3R,5S)-1-tert-butoxycarbonyl-5-formyl-3-methoxymethoxymethylpyrrolidin-2-yl>-8-methoxy-3,4-dihydro-2(1H)-isoquinolinecarboxylate <3aR-<1<1S*,3(R*),5R*,6R*>,3aα,6α,7aβ>>-1-<<3-<2-(methoxymethoxy)-1-(2-methoxy-6-methylphenyl)ethyl>-8-methyl-2,4-dioxo-3,8-diazabicyclo<3.2.1>oct-6-yl>carbonyl>hexahydro-8,8-dimethyl-2,2-dioxo-3H-3a,6-methano-2,1-benzisothiazole 3-((R)-2-hydroxy-1-(2-methoxy-6-methylphenyl)ethyl)-6-methyl-3,6-diazabicyclo[3.1.0]hexane-2,4-dione (2S)-2-((S)-2-(N-(tert-butoxycarbonyl)-4-methylphenylsulfonamido)-3-((tert-butyldiphenylsilyl)oxy)propyl)-3-((methylsulfonyl)oxy)pent-4-yn-1-yl acetate