化合物简介
Dotarizine is a drug used in the treatment of migraine, which acts as a calcium channel blocker, and also as an antagonist at the 5HT2A receptor, and to a lesser extent at the 5HT1A and 5HT2C receptors. The anti-migraine action is thought to be due to its action as a vasodilator, but it also has some anxiolytic effects and blocks amnesia produced by electroconvulsive shock in animals.
基本信息
中文名称
多他利嗪
英文名称
1-benzhydryl-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine
中文别名
英文别名
DOTARIZINE、Dotarizinum、Dotarizina
CAS号
84625-59-2
分子式
C29H34N2O2
分子量
442.592
精确质量
442.262
PSA
24.94
LOGP
4.9494
物化性质
密度
1.122 g/cm3
沸点
557.4ºC at 760 mmHg
熔点
100-101ºC
闪点
147.9ºC
折射率
1.587
安全信息
海关编码
2933599090
