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(1S,4S,5R,6R,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxymethyl)-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]octan-2-one

CAS号：852546-59-9

英文名：(1S,4S,5R,6R,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxymethyl)-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]octan-2-one

分子式：C29H46O6Si

分子量：518.757

合成路线

852546-51-1

(Z)-methyl trans-4,5-(isopropylidenedioxy)-2-hexenoate

852546-59-9

(1S,4S,5R,6R,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxymethyl)-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]octan-2-one

852546-52-2

(1S,2R,3S,4S,7R)-7-(tert-Butyl-dimethyl-silanyloxy)-5-oxo-3-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester

852546-59-9

(1S,4S,5R,6R,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxymethyl)-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]octan-2-one

852546-53-3

(1S,2S,4S,5R,6R,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxymethyl-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]octan-2-ol

852546-59-9

(1S,4S,5R,6R,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxymethyl)-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]octan-2-one

852546-54-4

2,2-Dimethyl-propionic acid (1S,2R,3R,4S,7R)-7-(tert-butyl-dimethyl-silanyloxy)-5-oxo-3-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]oct-2-ylmethyl ester

852546-59-9

(1S,4S,5R,6R,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxymethyl)-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]octan-2-one

852546-64-6

2,2-Dimethyl-propionic acid (1S,2R,3R,4S,5S,7R)-7-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-3-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]oct-2-ylmethyl ester

852546-59-9

(1S,4S,5R,6R,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxymethyl)-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]octan-2-one

99603-55-1

(4S,5R)-2,2,5-trimethyl-1,3-dioxolane-4-carbaldehyde

852546-59-9

(1S,4S,5R,6R,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxymethyl)-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]octan-2-one

132617-05-1

acetic acid (1S,4R)-(-)-4-hydroxycyclohex-2-enyl ester

852546-59-9

(1S,4S,5R,6R,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxymethyl)-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]octan-2-one

164414-40-8

cis-(1S,4R)-4-(tert-butyldimethylsilyloxy)cyclohex-2-enol

852546-59-9

(1S,4S,5R,6R,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxymethyl)-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]octan-2-one

上游原料

(4S,5R)-2,2,5-trimethyl-1,3-dioxolane-4-carbaldehyde 2,2-Dimethyl-propionic acid (1S,2R,3R,4S,7R)-7-(tert-butyl-dimethyl-silanyloxy)-5-oxo-3-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]oct-2-ylmethyl ester 2,2-Dimethyl-propionic acid (1S,2R,3R,4S,5S,7R)-7-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-3-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]oct-2-ylmethyl ester (1S,2R,3S,4S,7R)-7-(tert-Butyl-dimethyl-silanyloxy)-5-oxo-3-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester (1S,2S,4S,5R,6R,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxymethyl-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]octan-2-ol acetic acid (1S,4R)-(-)-4-hydroxycyclohex-2-enyl ester cis-(1S,4R)-4-(tert-butyldimethylsilyloxy)cyclohex-2-enol (Z)-methyl trans-4,5-(isopropylidenedioxy)-2-hexenoate

下游产品

(1S,2S,4R,7R,8R)-2-[(E)-2-(Dimethyl-phenyl-silanyl)-vinyl]-8-(4-methoxy-benzyloxymethyl)-7-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]oct-5-en-2-ol (1S,2S,4S,5R,7R,8R)-2-[(E)-2-(Dimethyl-phenyl-silanyl)-vinyl]-8-(4-methoxy-benzyloxymethyl)-7-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]octane-2,5-diol (1R,2R)-1-[(1S,2R,3R,4R,7S)-7-[(E)-2-(Dimethyl-phenyl-silanyl)-vinyl]-7-hydroxy-3-(4-methoxy-benzyloxymethyl)-bicyclo[2.2.2]oct-5-en-2-yl]-propane-1,2-diol (1S,2S,4S,5R,6R,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-2-(dimethyl-phenyl-silanyl)-vinyl]-5-(4-methoxy-benzyloxymethyl)-6-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]octan-2-ol Thiocarbonic acid O-[(1S,2R,4S,5S,7R,8R)-5-[(E)-2-(dimethyl-phenyl-silanyl)-vinyl]-5-hydroxy-7-(4-methoxy-benzyloxymethyl)-8-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.2]oct-2-yl] ester O-p-tolyl ester