化合物简介
Linsitinib is an experimental drug candidate for the treatment of various types of cancer. It is an inhibitor of the insulin receptor and of the insulin-like growth factor 1 receptor (IGF-1R). This prevents tumor cell proliferation and induces tumor cell apoptosis.
基本信息
中文名称
Linsitinib
英文名称
3-[8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutan-1-ol
中文别名
顺式-3-[8-氨基-1-(2-苯基-7-喹啉基)咪唑并[1,5-A]吡嗪-3-基]-1-甲基环丁醇
英文别名
Kinome_3532、Linsitinib、cis-3-[8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-1-yl]-1-methylcyclobutan-1-ol、OSI-906 (Linsitinib)、cis-3-(8-amino-1-(2-phenyl-7-quinolinyl)imidazo(1,5-a)pyrazin-3-yl)-1-methylcyclobutanol、cis-3-[8-amino-1-(2-phenyl-quinolin-7-yl)-imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol、OSI-906AA、OSI906
CAS号
867160-71-2
分子式
C26H23N5O
分子量
421.494
精确质量
421.19
PSA
89.33
LOGP
5.4033
编号系统
MDL号
MFCD12912153
物化性质
密度
1.39 g/cm3
合成路线
