化合物简介
Ivacaftor (trade name Kalydeco, developed as VX-770) is a drug used to treat cystic fibrosis in people with certain mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, who account for 4–5% cases of cystic fibrosis, and is included in a combination drug, lumacaftor/ivacaftor, which is used to treat people with cystic fibrosis who have the F508del mutation in CFTR.
基本信息
中文名称
N-(2,4-二叔丁基-5-羟基苯基)-1,4-二氢-4-氧代-3-喹啉甲酰胺
英文名称
ivacaftor
中文别名
英文别名
UNII-1Y740ILL1Z、VX770,VX 770,Ivacaftor、N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide、N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide、Ivacaftor、N-(2,4-ditert-butyl-5-hydroxyphenyl)-4-oxo-1H-quinoline-3-carboxamide、[14C]-Ivacaftor、N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxaraide、Ivacaftor (VX-770)、N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide、Kalydeco、VX770
CAS号
873054-44-5
分子式
C24H28N2O3
分子量
392.491
精确质量
392.21
PSA
85.68
LOGP
5.465
编号系统
MDL号
MFCD17171361
物化性质
密度
1.187 g/cm3
沸点
550.4ºC at 760 mmHg
闪点
286.7ºC
上游原料
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