化合物简介
CK 1827452 is a promising new drug in systolic heart failure. It accelerates the transition of myosin into the force-generating state without affecting cardiac myocyte calcium homeostasis. CK 1827452 increases cardiac function by increasing the duration of ejection without changing the rates of contraction.
基本信息
中文名称
Omecamtiv mecarbil
英文名称
methyl 4-[[2-fluoro-3-[(6-methylpyridin-3-yl)carbamoylamino]phenyl]methyl]piperazine-1-carboxylate
中文别名
英文别名
methyl 4-(2-fluoro-5-(3-(6-methylpyridin-3-yl)ureido)benzyl)piperazine-1-carboxylate、methyl 4-(2-fluoro-3-(3-(6-methylpyridin-3-yl)ureido)benzyl)piperazine-1-carboxylate、methyl 4-[(2-fluoro-3-{[(6-methyl(3-pyridyl))amino]carbonylamino}phenyl)methyl]piperazinecarboxylate、Omecamtiv mecarbil (USAN/INN)、Omecamtiv mecarbil
CAS号
873697-71-3
分子式
C20H24FN5O3
分子量
401.435
精确质量
401.186
PSA
90.29
LOGP
3.0195
编号系统
MDL号
MFCD18633260
物化性质
密度
1.344 g/cm3
沸点
456.78ºC at 760 mmHg
闪点
230.052ºC
合成路线
上游原料
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