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巴佛洛霉素A1

巴佛洛霉素A1

CAS号：88899-55-2

英文名：bafilomycin A1

分子式

C35H58O9

熔点

密度

1.12 g/cm3

分子量

622.83

沸点

770.1ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

The bafilomycins are a family of toxic macrolide antibiotic derived from Streptomyces griseus. These compounds all appear in the same fermentation and have quite similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase.

基本信息

中文名称

巴佛洛霉素A1

英文名称

bafilomycin A1

中文别名

维生素 D2

英文别名

(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-((1S,2R,3S)-2-hydroxy-1-methyl-3-((2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5、Bafilomycin A1 from Streptomycesgriseus,10 ug、21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-hygrolidin、bafilomycin、BAFILOMYCIN A1、BafilomycinA1fromStreptomycesgriseus、(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-Methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-Methyl-6-(1-Methylethyl)-2H-pyran-2-yl]butyl]-3,15-diMethoxy-5,7,9,11-tetraMethyloxacyclohexadeca-3,5,11,13-tetraen-2-o、bafilomycin A

CAS号

88899-55-2

分子式

C35H58O9

分子量

622.83

精确质量

622.408

PSA

134.91

LOGP

4.6927

编号系统

BRN号

4730700

PubChem号

24891613

MDL号

MFCD06795130

物化性质

密度

1.12 g/cm3

沸点

770.1ºC at 760 mmHg

闪点

232.2ºC

折射率

1.534

储存条件

2-8ºC

安全信息

安全说明

S26; S36

危险类别码

R36/37/38

危险品运输编码

UN 3172

危险类别

6.1(b)

包装等级

III

危险品标志

Xi

合成路线

(3Z,5E,11E,13E)-(7R,8S,9S,15S,16R)-16-{(1S,2R,3S)-3-[2-((2R,3S,4R)-2,4-Dihydroxy-3,5-dimethyl-hexyl)-[1,3]dithian-2-yl]-2-hydroxy-1-methyl-butyl}-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one

(3Z,5E,11E,13E)-(7R,8S,9S,15S,16R)-16-{(1S,2R,3S)-3-[2-((2R,3S,4R)-2,4-Dihydroxy-3,5-dimethyl-hexyl)-[1,3]dithian-2-yl]-2-hydroxy-1-methyl-butyl}-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one

巴佛洛霉素A1

巴佛洛霉素A1

上游原料

共找到99个上游原料 >

(2R,3S,4S)-3-(tert-butyldimethylsilyloxy)-2,4-dimethyl-6-heptyn-1-ol

(2R,3S,4S)-3-(tert-butyldimethylsilyloxy)-2,4-dimethyl-6-heptyn-1-ol

(2R,3S,4S,E)-3-((tert-butyldimethylsilyl)oxy)-7-iodo-2,4,6-trimethylhept-6-en-1-ol

(2R,3S,4S,E)-3-((tert-butyldimethylsilyl)oxy)-7-iodo-2,4,6-trimethylhept-6-en-1-ol

(2E,8E,4R,5S,6S)-5-(tert-butyldimethylsilyloxy)-9-iodo-2,4,6,8-tetramethyl-2,8-nonadienal

(2E,8E,4R,5S,6S)-5-(tert-butyldimethylsilyloxy)-9-iodo-2,4,6,8-tetramethyl-2,8-nonadienal

methyl (2Z,4E,6R,7S,8S,10E,12E,14S,15R,16S,17R,18S)-18-(2-((2R,3S,4R)-2,4-bis((tert-butyldimethylsilyl)oxy)-3,5-dimethylhexyl)-1,3-dithian-2-yl)-17-hydroxy-2,14-dimethoxy-4,6,8,10,16-pentamethyl-7,15-bis((triethylsilyl)oxy)nonadeca-2,4,10,12-tetraenoate

methyl (2Z,4E,6R,7S,8S,10E,12E,14S,15R,16S,17R,18S)-18-(2-((2R,3S,4R)-2,4-bis((tert-butyldimethylsilyl)oxy)-3,5-dimethylhexyl)-1,3-dithian-2-yl)-17-hydroxy-2,14-dimethoxy-4,6,8,10,16-pentamethyl-7,15-bis((triethylsilyl)oxy)nonadeca-2,4,10,12-tetraenoate

(4R,5S,6S)-8-methoxymethoxy-2,4,6-trimethyl-5-(triethylsilanyloxy)-oct-2-trans-enoic acid ethyl ester

(4R,5S,6S)-8-methoxymethoxy-2,4,6-trimethyl-5-(triethylsilanyloxy)-oct-2-trans-enoic acid ethyl ester

(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-((2S,3R,4S)-4-(2-((2R,3S,4R)-2,4-bis((tert-butyldimethylsilyl)oxy)-3,5-dimethylhexyl)-1,3-dithian-2-yl)-3-hydroxypentan-2-yl)-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one

(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-((2S,3R,4S)-4-(2-((2R,3S,4R)-2,4-bis((tert-butyldimethylsilyl)oxy)-3,5-dimethylhexyl)-1,3-dithian-2-yl)-3-hydroxypentan-2-yl)-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one

上游原料

(2R,3S,4S)-3-(tert-butyldimethylsilyloxy)-2,4-dimethyl-6-heptyn-1-ol (2R,3S,4S,E)-3-((tert-butyldimethylsilyl)oxy)-7-iodo-2,4,6-trimethylhept-6-en-1-ol (2E,8E,4R,5S,6S)-5-(tert-butyldimethylsilyloxy)-9-iodo-2,4,6,8-tetramethyl-2,8-nonadienal methyl (2Z,4E,6R,7S,8S,10E,12E,14S,15R,16S,17R,18S)-18-(2-((2R,3S,4R)-2,4-bis((tert-butyldimethylsilyl)oxy)-3,5-dimethylhexyl)-1,3-dithian-2-yl)-17-hydroxy-2,14-dimethoxy-4,6,8,10,16-pentamethyl-7,15-bis((triethylsilyl)oxy)nonadeca-2,4,10,12-tetraenoate (4R,5S,6S)-8-methoxymethoxy-2,4,6-trimethyl-5-(triethylsilanyloxy)-oct-2-trans-enoic acid ethyl ester (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-((2S,3R,4S)-4-(2-((2R,3S,4R)-2,4-bis((tert-butyldimethylsilyl)oxy)-3,5-dimethylhexyl)-1,3-dithian-2-yl)-3-hydroxypentan-2-yl)-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one [3S,4R,5R,6R,7R,8R]-6-[(tert-butyldimethylsilyl)oxy]-8-[(3,4-dimethoxybenzyl)oxy]-5,7-dimethyl-3-methoxynon-1-en-4-ol 2,2-dimethylpropionic acid (4R,5S,6S)-5,8-dihydroxy-2,4,6-trimethyl-oct-2-trans-enyl ester (3R,4S,5S)-4-benzyloxymethoxy-7-methoxymethoxy-3,5-dimethylheptanoic acid methyl ester (2E,4R,5S,6S,8E)-9-iodo-2,4,6,8-tetramethyl-5-(triethylsilyloxy)nona-2,8-dien-1-ol (3S,4S,5R)-4-((tert-butyldimethylsilyl)oxy)-6-((4-methoxybenzyl)oxy)-3,5-dimethylhexanal (2R,3R,4S,5S,6R,7S)-4-((tert-butyldimethylsilyl)oxy)-7-methoxy-3,5-dimethyl-6-((triethylsilyl)oxy)non-8-yn-2-ol [3S,4R,5R,6S,7R,8R]-6-[(tert-butyldimethylsilyl)oxy]-8-[(3,4-dimethoxybenzyl)oxy]-5,7-dimethyl-3-methoxy-4-[(triethylsilyl)oxy]non-1-ene 2,2-dimethylpropionic acid (4R,5S,6S)-9-iodo-2,4,6,8-tetramethyl-5-(triethylsilanyloxy)-nona-2,8-trans-dienyl ester (4R,5S,6S,E)-ethyl 5-hydroxy-8-(methoxymethoxy)-2,4,6-trimethyloct-2-enoate (3S,4S)-4-[(benzyloxy)methoxy]-5-(tert-butyldiphenylsilanyloxy)-3-methylpentanoic acid methyl ester (3R,4S,5S)-4-Benzyloxymethoxy-2-hydroxy-7-methoxymethoxy-3,5-dimethyl-heptanoic acid methyl ester methyl (2Z,4E,6R,7S,8S,10E,12E,14S,15R,16S,17R,18S)-18-(2-((2R,3S,4R)-2,4-bis((tert-butyldimethylsilyl)oxy)-3,5-dimethylhexyl)-1,3-dithian-2-yl)-7,15,17-trihydroxy-2,14-dimethoxy-4,6,8,10,16-pentamethylnonadeca-2,4,10,12-tetraenoate tert-butyl(((2R,3S,4S)-1-((4-methoxybenzyl)oxy)-2,4-dimethylhept-6-yn-3-yl)oxy)dimethylsilane (2R,3S,4S,E)-3-((diethyl(isopropyl)silyl)oxy)-7-iodo-2,4,6-trimethylhept-6-en-1-yl pivalate (3S,4S,5R)-4-((tert-butyldimethylsilyl)oxy)-6-((4-methoxybenzyl)oxy)-3,5-dimethylhexan-1-ol (2E,4R,5S,6S,8E)-ethyl 5-((tert-butyldimethylsilyl)oxy)-9-iodo-2,4,6,8-tetramethylnona-2,8-dienoate (2R,3R,4R)-1-[(para-methoxybenxyl)oxy]-2,4-dimethyl-3-hexanol (2S,3S,4S,E)-3-((tert-butyldimethylsilyl)oxy)-7-iodo-2,4,6-trimethylhept-6-enal (2E,8E,4R,5S,6S)-5-(tert-butyldimethylsilyloxy)-1-iodo-2,4,6,8-tetramethyl-2,8-nonadien-1-ol (4R,5S,6S)-9-iodo-2,4,6,8-tetramethyl-5-(triethylsilanyloxy)-nona-2,8-trans-dienal (3S,4S)-4-Benzyloxymethoxy-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pentan-1-ol (4R,5S,6S,E)-2,4,6-trimethyl-5,8-bis((triethylsilyl)oxy)oct-2-en-1-yl pivalate (2Z,4E,6R,7S,8S,10E,12E,14S,15R,16S,17R,18S)-18-(2-((2R,3S,4R)-2,4-bis((tert-butyldimethylsilyl)oxy)-3,5-dimethylhexyl)-1,3-dithian-2-yl)-7,15,17-trihydroxy-2,14-dimethoxy-4,6,8,10,16-pentamethylnonadeca-2,4,10,12-tetraenoic acid methyl (2Z,4E,10E,6R,7S,8S)-7-(tert-butyldimethylsilyl)-11-iodo-2-methoxy-4,6,8,10-tetramethyl-2,4,10-undecatrienoate (3Z,5E,11E,13E)-(7R,8S,9S,15S,16R)-16-{(1S,2R,3S)-3-[2-((2R,3S,4R)-2,4-Dihydroxy-3,5-dimethyl-hexyl)-[1,3]dithian-2-yl]-2-hydroxy-1-methyl-butyl}-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one (2S,4S,5S)-7-methoxymethoxy-3,5-dimethylheptane-1,2,4-triol (4S,5S)-4-benzyloxymethoxy-7-methoxymethoxy-5-methylhept-2-trans-enoic acid methyl ester 2,2-dimethylpropionic acid (4R,5S,6S)-8-methoxymethoxy-2,4,6-trimethyl-5-(triethylsilanyloxy)-oct-2-trans-enyl ester methyl (2Z,4E,10E,6R,7S,8S)-7-hydroxy-11-iodo-2-methoxy-4,6,8,10-tetramethyl-2,4,10-undecatrienoate (6R,7S,8S)-11-iodo-2-methoxy-4,6,8,10-tetramethyl-7-(triethylsilanyloxy)-undeca-2,4,10-trans-trienoic acid methyl ester 2,2-dimethylpropionic acid (4R,5S,6S)-8-hydroxy-2,4,6-trimethyl-5-(triethylsilanyloxy)-oct-2-trans-enyl ester 2,2-dimethylpropionic acid (4R,5S,6S)-2,4,6-trimethyl-5-(triethylsilanyloxy)-non-2-trans-en-8-ynyl ester tert-butyl(((2R,3S,4S)-1-((4-methoxybenzyl)oxy)-2,4-dimethylhex-5-en-3-yl)oxy)dimethylsilane tert-Butyl-{(1S,2S)-5,5-dibromo-1-[(R)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2-methyl-pent-4-enyloxy}-dimethyl-silane (4R,5S,6S,E)-8-(methoxymethoxy)-2,4,6-trimethyl-5-((triethylsilyl)oxy)oct-2-en-1-ol (7S,8S)-8-((benzyloxy)methoxy)-7,12,12-trimethyl-11,11-diphenyl-2,4,10-trioxa-11-silatridecane (2R,3R,4S,5R,6R,7S)-4-((tert-butyldimethylsilyl)oxy)-7-methoxy-3,5-dimethylnon-8-yne-2,6-diol (2R,3R,4S,5S,6R,7R)-5-((tert-butyldimethylsilyl)oxy)-7-((3,4-dimethoxybenzyl)oxy)-2-methoxy-4,6-dimethyl-3-((triethylsilyl)oxy)octanal (4E,10E)-(6R,7S,8S)-3-Hydroxy-11-iodo-2-methoxy-4,6,8,10-tetramethyl-7-triethylsilanyloxy-undeca-4,10-dienoic acid methyl ester