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托烷司琼

托烷司琼

CAS号:89565-68-4
英文名:tropisetron
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化合物简介
Tropisetron (INN) is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy, although it has been used experimentally as an analgesic in cases of fibromyalgia. The drug is available in a 5mg oral preparation or in 2mg intravenous form. It is marketed by Novartis in Europe, Australia, New Zealand, Japan, South Korea and the Philippines as Navoban, but is not available in the U.S. It is also available from Novell Pharmaceutical Laboratories and marketed in several Asian countries as Setrovel.
基本信息
编号系统
物化性质
安全信息
生产方法及用途
生产方法
吲哚-3-甲酸溶于甲苯,加入亚硫酰氯,搅拌回流反应,蒸出部分甲苯,在50℃缓慢加入托品醇的甲苯溶液反应,蒸出甲苯,冷却,加入乙酸乙酯和水,搅拌,滴加氨水调节pH值,分出有机层,干燥后蒸出乙酸乙酯;得到的物质溶于乙醇,通入氯化氢气体至pH为3,过滤,浓缩,冷却即得托烷司琼。
用途
为5-羟色胺拮抗药。
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