化合物简介
AST-1306 is a selective irreversible inhibitor of the epidermal growth factor receptor (EGFR) 1 and 2. Studies show that AST-1306 inhibited the enzymatic activities of wild-type EGF) and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems. AST-1306 was more effective in inhibiting tumors with ErbB2-overexpressing cells than EGFR-overexpressing tumor.
基本信息
中文名称
N-[4-[[3-氯-4-[(3-氟苯基)甲氧基]苯基]氨基]-6-喹唑啉]-2-丙酰胺
英文名称
N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]prop-2-enamide
中文别名
英文别名
QCR-149、AST 1306
CAS号
897383-62-9
分子式
C24H18ClFN4O2
分子量
448.877
精确质量
448.11
PSA
79.63
LOGP
6.5919
编号系统
MDL号
MFCD17169993
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