百科

(3R,4R)-3-(5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉)-4-(1H-吲哚)-2,5-吡咯烷二酮

CAS号：905854-02-6

英文名：3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione

分子式

C23H19N3O2

熔点

密度

1.5g/cm3

分子量

369.416

沸点

715.95ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Tivantinib (ARQ197; by Arqule, Inc.) is an experimental anti-cancer drug. It is a bisindolylmaleimide that binds to the dephosphorylated MET kinase in vitro. Tivantinib is being tested clinically as a highly selective MET inhibitor. However, the mechanism of action of tivantinib is still unclear.; Tivantinib displays cytotoxic activity via molecular mechanisms that are independent from its ability to bind MET.

基本信息

中文名称

(3R,4R)-3-(5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉)-4-(1H-吲哚)-2,5-吡咯烷二酮

英文名称

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione

中文别名

祖师麻甲素.瑞香素、TIVANTINIB ARQ-197、(3R,4R)-3-(5,6-二氢-4H-吡咯并[3,2,1-IJ]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮

英文别名

Tivantinib/ARQ197/ARQ-197、(-)-3(R),4(R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione、Tivantinib (ARQ 197)、(-)-3(R),4(R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione,(-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione、(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-2,5-pyrrolidinedione、Tivantinib、(-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

CAS号

905854-02-6

分子式

C23H19N3O2

分子量

369.416

精确质量

369.148

PSA

66.89

LOGP

3.9214