百科

Oprozomib

CAS号：935888-69-0

英文名：N-[(2S)-3-methoxy-1-[[(2S)-3-methoxy-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide

分子式

C25H32N4O7S

熔点

密度

分子量

532.609

沸点

溶解度

信号词

危险品标志

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化合物简介

Oprozomib (INN, codenamed ONX 0912 and PR-047) is an orally active second-generation proteasome inhibitor developed by Onyx Pharmaceuticals, an Amgen subsidiary. It is being investigated for the treatment of hematologic malignancies, specifically, multiple myeloma, with Phase 1b studies ongoing (as of February 16, 2016). Being an epoxyketone derivative, oprozomib is structurally related to carfilzomib and has the added benefit of being orally bioavailable. It selectively inhibits chymotrypsin-like activity of both the constitutive proteasome (PSMB5) and immunoproteasome (LMP7). Like carfilzomib, it is active against bortezomib-resistant multiple myeloma cells.

基本信息

中文名称

Oprozomib

英文名称

N-[(2S)-3-methoxy-1-[[(2S)-3-methoxy-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide

中文别名

英文别名

ONX-0912、QC-9273、Oprozomib、PR-047

CAS号

935888-69-0

分子式

C25H32N4O7S

分子量

532.609

精确质量

532.199

PSA