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3'-tert-butyldimethylsilyloxy-dolastatin 19

3'-tert-butyldimethylsilyloxy-dolastatin 19

CAS号：944804-22-2

英文名：3'-tert-butyldimethylsilyloxy-dolastatin 19

分子式

C35H59BrO10Si

熔点

密度

分子量

747.826

沸点

溶解度

信号词

危险品标志

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基本信息

中文名称

3'-tert-butyldimethylsilyloxy-dolastatin 19

英文名称

3'-tert-butyldimethylsilyloxy-dolastatin 19

中文别名

英文别名

(E)-(1S,2S,5R,9S,11S,12R,13S)-5-((1E,3E)-4-Bromo-buta-1,3-dienyl)-13-[(2R,3R,4R,5S,6S)-4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethoxy-6-methyl-tetrahydro-pyran-2-yloxy]-1-hydroxy-9-methoxy-2,7,12-trimethyl-4,15-dioxa-bicyclo[9.3.1]pentadec-7-en-3-one

CAS号

944804-22-2

分子式

C35H59BrO10Si

分子量

747.826

精确质量

746.306

PSA

111.14

LOGP

6.4182

合成路线

tert-Butyl-((2S,3R,4R,5S,6S)-2-fluoro-3,5-dimethoxy-6-methyl-tetrahydro-pyran-4-yloxy)-dimethyl-silane

tert-Butyl-((2S,3R,4R,5S,6S)-2-fluoro-3,5-dimethoxy-6-methyl-tetrahydro-pyran-4-yloxy)-dimethyl-silane

(E)-(1S,2S,5R,9S,11S,12R,13S)-5-((1E,3E)-4-Bromo-buta-1,3-dienyl)-1,13-dihydroxy-9-methoxy-2,7,12-trimethyl-4,15-dioxa-bicyclo[9.3.1]pentadec-7-en-3-one

(E)-(1S,2S,5R,9S,11S,12R,13S)-5-((1E,3E)-4-Bromo-buta-1,3-dienyl)-1,13-dihydroxy-9-methoxy-2,7,12-trimethyl-4,15-dioxa-bicyclo[9.3.1]pentadec-7-en-3-one

3'-tert-butyldimethylsilyloxy-dolastatin 19

3'-tert-butyldimethylsilyloxy-dolastatin 19

上游原料

共找到5个上游原料 >

(E)-(1S,2S,5R,9S,11S,12R,13S)-5-((1E,3E)-4-Bromo-buta-1,3-dienyl)-1,13-dihydroxy-9-methoxy-2,7,12-trimethyl-4,15-dioxa-bicyclo[9.3.1]pentadec-7-en-3-one

(E)-(1S,2S,5R,9S,11S,12R,13S)-5-((1E,3E)-4-Bromo-buta-1,3-dienyl)-1,13-dihydroxy-9-methoxy-2,7,12-trimethyl-4,15-dioxa-bicyclo[9.3.1]pentadec-7-en-3-one

(2R,5S,6E,9R,10E,12E)-9-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-13-bromo-2,7-dimethyl-trideca-6,10,12-trien-3-one

(2R,5S,6E,9R,10E,12E)-9-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-13-bromo-2,7-dimethyl-trideca-6,10,12-trien-3-one

tert-Butyl-((2S,3R,4R,5S,6S)-2-fluoro-3,5-dimethoxy-6-methyl-tetrahydro-pyran-4-yloxy)-dimethyl-silane

tert-Butyl-((2S,3R,4R,5S,6S)-2-fluoro-3,5-dimethoxy-6-methyl-tetrahydro-pyran-4-yloxy)-dimethyl-silane

(2R,3S,5S,6E,9R,10E,12E)-9-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxybenzyloxy)-5-methoxy-13-bromo-2,7-dimethyl-3-triethylsilyloxy-trideca-6,10,12-triene

(2R,3S,5S,6E,9R,10E,12E)-9-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxybenzyloxy)-5-methoxy-13-bromo-2,7-dimethyl-3-triethylsilyloxy-trideca-6,10,12-triene

(S)-2-[(2S,4S,5S,6S)-6-[(3E,7E,9E)-(2S,6R)-10-Bromo-6-(tert-butyl-dimethyl-silanyloxy)-2-methoxy-4-methyl-deca-3,7,9-trienyl]-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxy-5-methyl-tetrahydro-pyran-2-yl]-propionic acid

(S)-2-[(2S,4S,5S,6S)-6-[(3E,7E,9E)-(2S,6R)-10-Bromo-6-(tert-butyl-dimethyl-silanyloxy)-2-methoxy-4-methyl-deca-3,7,9-trienyl]-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxy-5-methyl-tetrahydro-pyran-2-yl]-propionic acid

上游原料

(E)-(1S,2S,5R,9S,11S,12R,13S)-5-((1E,3E)-4-Bromo-buta-1,3-dienyl)-1,13-dihydroxy-9-methoxy-2,7,12-trimethyl-4,15-dioxa-bicyclo[9.3.1]pentadec-7-en-3-one (2R,5S,6E,9R,10E,12E)-9-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-13-bromo-2,7-dimethyl-trideca-6,10,12-trien-3-one tert-Butyl-((2S,3R,4R,5S,6S)-2-fluoro-3,5-dimethoxy-6-methyl-tetrahydro-pyran-4-yloxy)-dimethyl-silane (2R,3S,5S,6E,9R,10E,12E)-9-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxybenzyloxy)-5-methoxy-13-bromo-2,7-dimethyl-3-triethylsilyloxy-trideca-6,10,12-triene (S)-2-[(2S,4S,5S,6S)-6-[(3E,7E,9E)-(2S,6R)-10-Bromo-6-(tert-butyl-dimethyl-silanyloxy)-2-methoxy-4-methyl-deca-3,7,9-trienyl]-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxy-5-methyl-tetrahydro-pyran-2-yl]-propionic acid