化合物简介
Tamibarotene (brand name: Amnolake), also called retinobenzoic acid, is orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity against acute promyelocytic leukaemia (APL) . It is currently marketed only in Japan and early trials have demonstrated that it tends to be better tolerated than ATRA. It has also been investigated as a possible treatment for Alzheimer's disease, multiple myeloma and Crohn's disease.
基本信息
中文名称
他米巴罗汀
英文名称
tamibarotene
中文别名
TAMIBAROTENE,AM 80,AM-80,AM80、4-[(5,5,8,8-四甲基-6,7-二氢萘-2-基)氨基甲酰]苯甲酸
英文别名
4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid、4-((5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl)benzoic acid
CAS号
94497-51-5
分子式
C22H25NO3
分子量
351.439
精确质量
351.183
PSA
66.4
LOGP
5.0591
编号系统
MDL号
MFCD00866188
物化性质
外观与性状
结晶固体
密度
1.154g/cm3
沸点
449.6ºC at 760mmHg
熔点
231-232ºC
闪点
225.7ºC
折射率
1.593
安全信息
海关编码
2924299090
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