百科

盐酸吉西他滨

盐酸吉西他滨

CAS号：95058-81-4

英文名：Gemcitabine

分子式

C9H11F2N3O4

熔点

168.64°C

密度

分子量

263.198

沸点

溶解度

信号词

危险品标志

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化合物简介

吉西他滨（英语：Gemcitabine），是用于化学疗法的核苷类似物。礼来公司的注册商品名为健择（Gemzar）。

基本信息

中文名称

盐酸吉西他滨

英文名称

Gemcitabine

中文别名

双氟脱氧胞苷、吉西他宾、吉西他滨碱、4-氨基-1-(3,3-二氟-4-羟基-5-羟甲基四氢呋喃-2-基)-1H-嘧啶-2-酮、4-氨基-1-[3,3-二氟-4-羟基-5-(羟甲基)氧杂环戊-2-基]嘧啶-2-酮

英文别名

3-DEOXY-2,2-DIFLUORO-D-RIBOFURANOSE-3,5-DIBENZOATE、4-AMINO-1-[(2R,4R,5R)-3,3-DIFLUORO-4-HYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL]PYRIMIDIN-2-ONE、GEMCITABINE, FREE BASE、2\'-DESOXY-2\',2\'-DIFLUORCYTIDINE、4-amino-1-[3,3-difluoro-4-hydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl]- 1H-pyrimidin- 2-one、GEMCITABINE HCL、2\'-DEOXY-2\',2\'-DIFLUOROCYTIDINE、1-(2-deoxy-2,2-difluoro-β-D-erythropentofuranosyl)cytosine、CYTIDINE, 2\'-DEOXY-2\',2\'-DIFLUORO

CAS号

95058-81-4

分子式

C9H11F2N3O4

分子量

263.198

精确质量

263.072

PSA

110.6

LOGP

-0.7074

编号系统

UNII

B76N6SBZ8R

物化性质

熔点

168.64°C

安全信息

安全说明

S25; S26; S36/37; S53

危险类别码

R21; R36/38; R46; R62; R63

生产方法及用途

用途

用途:适用于治疗中、晚期非小细胞肺癌

合成路线

共找到3条合成路线 >

β-2',2'-difluoro-3',5'-bis-(3-fluorobenzoyloxy)-2'-deoxycytidine

β-2',2'-difluoro-3',5'-bis-(3-fluorobenzoyloxy)-2'-deoxycytidine

盐酸吉西他滨

盐酸吉西他滨

上游原料

共找到22个上游原料 >

4-氨基-1-[(2R,4R,5R)-3,3-二氟-4-羟基-5-(羟基甲基)四氢呋喃-2-基]嘧啶-2-酮盐酸盐

4-氨基-1-[(2R,4R,5R)-3,3-二氟-4-羟基-5-(羟基甲基)四氢呋喃-2-基]嘧啶-2-酮盐酸盐

1-(2'-deoxy-2',2'-difluoro-5-benzoyl-3-(4-phenyl)benzoyl-β-D-arabinofuranosyl)-4-aminopyrimidine-2-one

1-(2'-deoxy-2',2'-difluoro-5-benzoyl-3-(4-phenyl)benzoyl-β-D-arabinofuranosyl)-4-aminopyrimidine-2-one

((2R,3R)-3-acetoxy-5-(1-((Z)-2-cyanovinyl)ureido)-4,4-difluorotetrahydrofuran-2-yl)methyl acetate

((2R,3R)-3-acetoxy-5-(1-((Z)-2-cyanovinyl)ureido)-4,4-difluorotetrahydrofuran-2-yl)methyl acetate

(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate hydrochloride

(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate hydrochloride

(2R,3R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4,4-difluorotetrahydrofuran-3-yl benzoate

(2R,3R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4,4-difluorotetrahydrofuran-3-yl benzoate

N4-benzoyl-2'-deoxy-2',2'-difluorocytidine

N4-benzoyl-2'-deoxy-2',2'-difluorocytidine

下游产品

共找到3个下游商品 >

α-gemcitabine

吉西他滨单磷酸酯

吉西他滨单磷酸酯

盐酸吉西他滨

盐酸吉西他滨

上游原料

4-氨基-1-[(2R,4R,5R)-3,3-二氟-4-羟基-5-(羟基甲基)四氢呋喃-2-基]嘧啶-2-酮盐酸盐 1-(2'-deoxy-2',2'-difluoro-5-benzoyl-3-(4-phenyl)benzoyl-β-D-arabinofuranosyl)-4-aminopyrimidine-2-one ((2R,3R)-3-acetoxy-5-(1-((Z)-2-cyanovinyl)ureido)-4,4-difluorotetrahydrofuran-2-yl)methyl acetate (2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate hydrochloride (2R,3R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4,4-difluorotetrahydrofuran-3-yl benzoate N4-benzoyl-2'-deoxy-2',2'-difluorocytidine D-(+)-核糖酸-gamma-内酯 N-trimethylsilyl-N-(2-trimethylsilyloxypyrimidin-4-yl)acetamide 盐酸吉西他滨 (3S,4R,5R)-3-fluoro-4-((triisopropylsilyl)oxy)-5-(((triisopropylsilyl)oxy)methyl)-dihydrofuran-2(3H)-one 1-[2'-deoxy-2',2'-difluoro-3',5'-bis(tert-butyldiphenylsilyloxy)-ribofuranosyl]-cytosine (2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl benzoate hydrochloride 2'-deoxy-2',2'-difluoro-3',5'-di-O-(triisopropylsilyl)cytidine 1-methylsulfonyl-2-deoxy-2,2-difluoro-3,5-di-O-(triisopropylsilyl)-D-ribofuranose 3,5-bis-O-(tert-butyldimethylsilyl)-1-O-(methanesulfonyl)-2-deoxy-2,2-difluororibose α-gemcitabine (S)-N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)pyrrolidine-2-carboxamide 2,2,2-trifluoroacetate 2-deoxy-2,2-difluoro-3,5-di-O-(triisopropylsilyl)-γ-D-ribonolactone 2-amino-N-(1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo- 1,2-dihydropyrimidin-4-yl)acetamide trifluoroacetic acid β-2',2'-difluoro-3',5'-bis-(3-fluorobenzoyloxy)-2'-deoxycytidine 2'-脱氧-2',2'-二氟-N-(1-氧代-2-丙基戊基)胞苷

下游产品

α-gemcitabine 吉西他滨单磷酸酯盐酸吉西他滨