化合物简介
Florbetapir (18F) (trade name AMYViD; also known as florbetapir-fluorine-18 or 18F-AV-45) is a PET scanning radiopharmaceutical compound containing the radionuclide fluorine-18, recently FDA approved as a diagnostic tool for Alzheimer's disease. Florbetapir, like Pittsburgh compound B (PiB), binds to beta-amyloid, however fluorine-18 has a half-life of 109.75 minutes, in contrast to PiB's radioactive half life of 20 minutes. Wong et al. found that the longer life allowed the tracer to accumulate significantly more in the brains of people with AD, particularly in the regions known to be associated with beta-amyloid deposits.
基本信息
中文名称
florbetapir F-18
英文名称
florbetapir F-18
中文别名
英文别名
4-[(E)-2-(6-{2-[2-(2-[F-18]fluoroethoxy)ethoxy]ethoxy}pyridin-3-yl)vinyl]-N-methylaniline、Florbetapir F-18、(E)-2-[2-[2-[2-(18F)fluoroethoxy]ethoxy]ethoxy]-5-[4-methylaminostyryl]pyridine、Amyvid (TN)、Florbetapir、UNII-6W15Z5R0RU、Amyvid、AV-45 compound、[18F]florbetapir、4-[(E)-2-[6-[2-[2-(2-fluoranylethoxy)ethoxy]ethoxy]pyridin-3-yl]ethenyl]-N-methylaniline、18F-AV-45
CAS号
956103-76-7
分子式
C20H25FN2O3
分子量
360.423
精确质量
360.185
PSA
52.61
LOGP
3.7482
编号系统
UNII
6W15Z5R0RU
合成路线
