化合物简介
Abiraterone acetate (INN, USAN, BAN, JAN) (brand names Zytiga, Abiratas, Abretone, Abirapro) is a steroidal antiandrogen, specifically an androgen synthesis inhibitor, used in combination with prednisone in metastatic castration-resistant prostate cancer (previously called hormone-resistant or hormone-refractory prostate cancer) – i.e., prostate cancer not responding to androgen deprivation or treatment with androgen receptor antagonists. It is a prodrug to the active agent abiraterone, and is marketed by Janssen Biotech under the trade name Zytiga. In addition, Intas Pharmaceuticals markets the drug under the trade name Abiratas, Cadila Pharmaceuticals markets the drug as Abretone, and Glenmark Pharmaceuticals as Abirapro.
基本信息
中文名称
阿比特龙
英文名称
abiraterone
中文别名
坦度酮罗、17-(3-吡啶基)雄甾-5,16-二烯-3beta-醇
英文别名
Abiraterone、(3beta)-17-(3-pyridinyl)-androsta-5,16-dien-3-ol
CAS号
154229-19-3
分子式
C24H31NO
分子量
349.509
精确质量
349.241
PSA
33.12
LOGP
5.3986
编号系统
MDL号
MFCD00924100
物化性质
密度
1.14g/cm3
沸点
500.2ºC at 760mmHg
闪点
256.3ºC
折射率
1.605
蒸汽压
7.99E-11mmHg at 25°C
安全信息
海关编码
2933399090
生产方法及用途
用途
雄激素拮抗药。
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