坎利酮

坎利酮

CAS号:976-71-6
英文名:Canrenone
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化合物简介
Canrenone (INN, USAN) (brand names Contaren, Luvion, Phanurane, Spiroletan), also known as aldadiene, is a steroidal antimineralocorticoid and weak antiandrogen and progestogen of the spirolactone group related to spironolactone which is or has been used as a diuretic in Europe, including in Italy and Belgium.
基本信息
编号系统
物化性质
生产方法及用途
生产方法
可用17-羟基-3-氧代-17α-孕甾-4-烯-21-羧酸-γ-内酯经脱氢制得。而前者则可从17α-炔基-3β,17β-二羟基雄甾-5-烯(即乙炔雄甾烯二醇)经炔基以甲基碘化镁置换、水解、成盐并催化氢化,生成3β,17β二羟基雄甾-5-烯-17α-丙酸钾,然后经内酯化及3-位羟基氧化制得该品。
用途
用于治疗心衰水肿和肝硬变腹水