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雷公藤内酯酮

雷公藤内酯酮

CAS号：38647-11-9

英文名：Triptonide

分子式

C20H22O6

熔点

密度

1.48 g/cm3

分子量

358.385

沸点

581.1ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Triptonide is a Triptolide analogue used in the preparation of cytotoxic fluorinated Triptolide.

基本信息

中文名称

雷公藤内酯酮

英文名称

Triptonide

中文别名

雷藤酮

英文别名

14-Deoxy-14-oxotriptolide、l-triptonide、TRIPTONIDE、Triptolide,14-deoxy-14-oxo

CAS号

38647-11-9

分子式

C20H22O6

分子量

358.385

精确质量

358.142

PSA

80.96

LOGP

1.3113

物化性质

外观与性状

白色结晶粉末

密度

1.48 g/cm3

沸点

581.1ºC at 760 mmHg

闪点

257.8ºC

折射率

1.637

合成路线

共找到4条合成路线 >

(5R,6S,8R,9S)-3-Isopropyl-9-methyl-7,8,9,11,12,15-hexahydro-6H-16,20-dioxa-cyclopropa[5,6]cyclopenta[a]phenanthrene-4,17-dione

(5R,6S,8R,9S)-3-Isopropyl-9-methyl-7,8,9,11,12,15-hexahydro-6H-16,20-dioxa-cyclopropa[5,6]cyclopenta[a]phenanthrene-4,17-dione

雷公藤内酯酮

雷公藤内酯酮

上游原料

共找到16个上游原料 >

Triptolide

(4bS,8aR)-8-((benzyloxy)methyl)-7-formyl-2-isopropyl-4b-methyl-4b,5,6,8a,9,10-hexahydrophenanthren-1-yl acetate

(4bS,8aR)-8-((benzyloxy)methyl)-7-formyl-2-isopropyl-4b-methyl-4b,5,6,8a,9,10-hexahydrophenanthren-1-yl acetate

雷公藤甲素

雷公藤甲素

(5R,6S,8R,9S)-3-Isopropyl-9-methyl-7,8,9,11,12,15-hexahydro-6H-16,20-dioxa-cyclopropa[5,6]cyclopenta[a]phenanthrene-4,17-dione

(5R,6S,8R,9S)-3-Isopropyl-9-methyl-7,8,9,11,12,15-hexahydro-6H-16,20-dioxa-cyclopropa[5,6]cyclopenta[a]phenanthrene-4,17-dione

(1R,2S,4aS,10aR)-1-((benzyloxy)methyl)-2-(hydroxymethyl)-7-isopropyl-4a-methyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1,8-diol

(1R,2S,4aS,10aR)-1-((benzyloxy)methyl)-2-(hydroxymethyl)-7-isopropyl-4a-methyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1,8-diol

二甲基亚砜

二甲基亚砜

下游产品

共找到3个下游商品 >

Triptolide

雷公藤甲素

雷公藤甲素

(5bS,6aS,7aR,8S,8aS,9aS,9bS,10aS,10bS)-8-ethyl-8-hydroxy-8a-isopropyl-10b-methyl-2,5,5b,6,6a,8,8a,9a,9b,10b-decahydrotris(oxireno)[2',3':4b,5;2'',3'':6,7;2''',3''':8a,9]phenanthro[1,2-c]furan-3(1H)-one

(5bS,6aS,7aR,8S,8aS,9aS,9bS,10aS,10bS)-8-ethyl-8-hydroxy-8a-isopropyl-10b-methyl-2,5,5b,6,6a,8,8a,9a,9b,10b-decahydrotris(oxireno)[2',3':4b,5;2'',3'':6,7;2''',3''':8a,9]phenanthro[1,2-c]furan-3(1H)-one

上游原料

Triptolide (4bS,8aR)-8-((benzyloxy)methyl)-7-formyl-2-isopropyl-4b-methyl-4b,5,6,8a,9,10-hexahydrophenanthren-1-yl acetate 雷公藤甲素 (5R,6S,8R,9S)-3-Isopropyl-9-methyl-7,8,9,11,12,15-hexahydro-6H-16,20-dioxa-cyclopropa[5,6]cyclopenta[a]phenanthrene-4,17-dione (1R,2S,4aS,10aR)-1-((benzyloxy)methyl)-2-(hydroxymethyl)-7-isopropyl-4a-methyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1,8-diol 二甲基亚砜 (3bR,9bS)-7-isopropyl-9b-methyl-1,5-dioxo-1,3,3b,4,5,9b,10,11-octahydrophenanthro[1,2-c]furan-6-yl acetate (3bR-反式)-3b,4,5,9b,10,11-六氢-6-甲氧基-9b-甲基-7-(1-甲基乙基)-菲并(1,2-c)呋喃-1(3H)-酮 (3bR,9bS)-7-isopropyl-9b-methyl-1-oxo-1,3,3b,4,5,9b,10,11-octahydrophenanthro[1,2-c]furan-6-yl acetate (3bR,9bS)-7-isopropyl-6-methoxy-9b-methyl-3b,4,10,11-tetrahydrophenanthro[1,2-c]furan-1,5(3H,9bH)-dione (2S,4aS,10aR)-8-Hydroxy-2-hydroxymethyl-7-isopropyl-4a-methyl-3,4,4a,9,10,10a-hexahydro-2H-phenanthren-1-one (4aS,10aR)-8-hydroxy-7-isopropyl-4a-methyl-3,4,4a,9,10,10a-hexahydrophenanthren-1(2H)-one (5aS,5bS,6aS,9aS,10aS,11aS)-8-isopropyl-5a-methyl-4,5,5a,10a,11,11a-hexahydrobis(oxireno)[2',3':4b,5;2'',3'':8a,9]phenanthro[1,2-c]furan-3,9(1H,6aH)-dione 雷酚酮内酯 (4bS,7R,8R,8aR)-8-((benzyloxy)methyl)-7-formyl-8-hydroxy-2-isopropyl-4b-methyl-4b,5,6,7,8,8a,9,10-octahydrophenanthren-1-yl acetate 7β,14,19-trihydroxy-18(4->3)abeo-abieta-3,8,11,13-tetraen-18-oic acid lactone

下游产品

Triptolide 雷公藤甲素 (5bS,6aS,7aR,8S,8aS,9aS,9bS,10aS,10bS)-8-ethyl-8-hydroxy-8a-isopropyl-10b-methyl-2,5,5b,6,6a,8,8a,9a,9b,10b-decahydrotris(oxireno)[2',3':4b,5;2'',3'':6,7;2''',3''':8a,9]phenanthro[1,2-c]furan-3(1H)-one