泰利霉素

泰利霉素

CAS号：191114-48-4

英文名：Telithromycin

分子式

C43H65N5O10

熔点

176-188ºC

密度

1.26 g/cm3

分子量

812.004

沸点

966.2ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Telithromycin is the first ketolide antibiotic to enter clinical use and is sold under the brand name of Ketek. It is used to treat community acquired pneumonia of mild to moderate severity. After significant controversy regarding safety and research fraud, the US Food and Drug Administration sharply curtailed the approved uses of the drug in 2007.

基本信息

中文名称

泰利霉素

英文名称

Telithromycin

中文别名

红霉酮(特利霉素)

英文别名

KETEK、(1R,2R,4R,6S,7R,8R,10R,13R,14S)-7-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-6-methoxy-2,4,6,8,10,14-hexamethyl-17-[4-(4-pyridin-3-ylimidazol-1-yl)butyl]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone

CAS号

191114-48-4

分子式

C43H65N5O10

分子量

812.004

精确质量

811.473

PSA

171.85

LOGP

4.8671

编号系统

UNII

KI8H7H19WL

物化性质

密度

1.26 g/cm3

沸点

966.2ºC at 760 mmHg

熔点

176-188ºC

闪点

538.2ºC

蒸汽压

0mmHg at 25°C

安全信息

安全说明

S26; S36

危险类别码

R36/37/38

危险品标志

Xi

合成路线

2',4''-di-O-bis(trimethylsilyl)-11-amino-11-N-[4-[4-(3-pyridyl)imidazol-1-yl]butyl]-11-deoxy-6-O-methylerythromycin A 11,12-cyclic carbamate

2',4''-di-O-bis(trimethylsilyl)-11-amino-11-N-[4-[4-(3-pyridyl)imidazol-1-yl]butyl]-11-deoxy-6-O-methylerythromycin A 11,12-cyclic carbamate

泰利霉素

上游原料

共找到10个上游原料 >

4-[4-(吡啶-3-基)咪唑-1-基]丁胺

4-[4-(吡啶-3-基)咪唑-1-基]丁胺

泰利霉素中间体 (7A)

泰利霉素中间体 (7A)

4-[4-(吡啶-3-基)咪唑-1-基]丁基酞酰亚胺

4-[4-(吡啶-3-基)咪唑-1-基]丁基酞酰亚胺

2',4''-di-O-acetylclarithromycin

2',4''-di-O-acetylclarithromycin

3-O-de-[(2,6-dideoxy-3-methyl-3-O-methyl-α-L-ribohexopyranosyl)oxy]-6-O-methyl-cyclic 11,12-carbonateerythromycin 2'-acetate

3-O-de-[(2,6-dideoxy-3-methyl-3-O-methyl-α-L-ribohexopyranosyl)oxy]-6-O-methyl-cyclic 11,12-carbonateerythromycin 2'-acetate

2'-O-acetyl-3-de[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyranosyl)oxy]-11,12-dideoxy-6-O-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]]erythromycin

2'-O-acetyl-3-de[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyranosyl)oxy]-11,12-dideoxy-6-O-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]]erythromycin

上游原料

4-[4-(吡啶-3-基)咪唑-1-基]丁胺泰利霉素中间体 (7A) 4-[4-(吡啶-3-基)咪唑-1-基]丁基酞酰亚胺 2',4''-di-O-acetylclarithromycin 3-O-de-[(2,6-dideoxy-3-methyl-3-O-methyl-α-L-ribohexopyranosyl)oxy]-6-O-methyl-cyclic 11,12-carbonateerythromycin 2'-acetate 2'-O-acetyl-3-de[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyranosyl)oxy]-11,12-dideoxy-6-O-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]]erythromycin 克拉霉素 2',4''-di-O-bis(trimethylsilyl)-11-amino-11-N-[4-[4-(3-pyridyl)imidazol-1-yl]butyl]-11-deoxy-6-O-methylerythromycin A 11,12-cyclic carbamate 3-(1H-咪唑-4-基)吡啶