化合物简介
Dabrafenib (trade name Tafinlar, GSK2118436) is a drug for the treatment of cancers associated with a mutated version of the gene BRAF. Dabrafenib acts as an inhibitor of the associated enzyme B-Raf, which plays a role in the regulation of cell growth. Dabrafenib has clinical activity with a manageable safety profile in clinical trials of phase 1 and 2 in patients with BRAF(V600)-mutated metastatic melanoma.
基本信息
中文名称
达帕菲尼
英文名称
dabrafenib
中文别名
达拉菲尼
英文别名
Dabrafenib [USAN:INN]、N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide、UNII-QGP4HA4G1B、Dabrafenib (USAN)、Dabrafenib、Tafinlar、N-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzene sulfonamide
CAS号
1195765-45-7
分子式
C23H20F3N5O2S2
分子量
519.562
精确质量
519.101
PSA
148.21
LOGP
6.4488
编号系统
UNII
QGP4HA4G1B
上游原料
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