百科

阿维菌素

阿维菌素

CAS号：65195-55-3

英文名：avermectin B1a

分子式

C48H72O14

熔点

157-162ºC

密度

1.24 g/cm3

分子量

873.077

沸点

940.9ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Avermectin B1a, a natural product derived from the soil actinomycete Streptomyces avermitilis, is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis.

基本信息

中文名称

阿维菌素

英文名称

avermectin B1a

中文别名

阿维菌素B1a、阿巴汀

英文别名

22,23-dihydroavermectinh B1a、abamectin component B1a、Avermectin B(1)a、Abamectin komponente B1a、Vertimec(R)018SC、AVERMECTIN B1A、Antibiotic C 076B1a、Abamectina [Spanish]、[3H]-Abamectin B1a、Abamectine [French]、Caswell No. 063AB、Abamectinum [Latin]

CAS号

65195-55-3

分子式

C48H72O14

分子量

873.077

精确质量

872.492

PSA

170.06

LOGP

5.3774

编号系统

UNII

K54ZMM929K

物化性质

外观与性状

白色结晶粉末

密度

1.24 g/cm3

沸点

940.9ºC at 760 mmHg

熔点

157-162ºC

闪点

268.1ºC

折射率

1.571

储存条件

通风低温干燥

安全信息

危险品运输编码

UN 2588

海关编码

2932999099

危险类别

6.1(a)

包装等级

II

合成路线

共找到2条合成路线 >

4'',5-di-O-tert-butyldimethylsilyl-22,23-dihydroavermectin B1

4'',5-di-O-tert-butyldimethylsilyl-22,23-dihydroavermectin B1

阿维菌素

上游原料

共找到62个上游原料 >

4'',5,7-tris[O-(trimethylsilyl)]-Δ2-4(R)-avermectin B1a

4'',5,7-tris[O-(trimethylsilyl)]-Δ2-4(R)-avermectin B1a

<2S(2R,4E,6S,7S)>-2-<2-(tert-butyldimethylsilyloxy)-6-(tert-butyldiphenylsilyloxy)-5,7-dimethylnona-4,8-dienyl>oxirane

<2S(2R,4E,6S,7S)>-2-<2-(tert-butyldimethylsilyloxy)-6-(tert-butyldiphenylsilyloxy)-5,7-dimethylnona-4,8-dienyl>oxirane

<2R(2E,4S,5S),4S,6S,8R(S),9S>-2-<4-hydroxy-3,5-dimethylhepta-2,6-dienyl>-9-methyl-8-(1-methypropyl)-1,7-dioxaspiro<5.5>undec-10-en-4-ol

<2R(2E,4S,5S),4S,6S,8R(S),9S>-2-<4-hydroxy-3,5-dimethylhepta-2,6-dienyl>-9-methyl-8-(1-methypropyl)-1,7-dioxaspiro<5.5>undec-10-en-4-ol

(2S,3S,E)-6-((2R,4S,6S,8R,9S)-8-((S)-sec-butyl)-4-((tert-butyldimethylsilyl)oxy)-9-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl)-3-((tert-butyldimethylsilyl)oxy)-2,4-dimethylhex-4-en-1-ol

(2S,3S,E)-6-((2R,4S,6S,8R,9S)-8-((S)-sec-butyl)-4-((tert-butyldimethylsilyl)oxy)-9-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl)-3-((tert-butyldimethylsilyl)oxy)-2,4-dimethylhex-4-en-1-ol

(1S,2S,3S,5S,6S)-3-[(tert-butyldiphenylsilyloxy)methyl]-5-methyl-2-[1-methylene-3-(phenylsulphonyl)propyl]-7-oxabicyclo[4.1.0]heptan-2-ol

(1S,2S,3S,5S,6S)-3-[(tert-butyldiphenylsilyloxy)methyl]-5-methyl-2-[1-methylene-3-(phenylsulphonyl)propyl]-7-oxabicyclo[4.1.0]heptan-2-ol

4'',5-bis<O-(dimethyl-tert-butylsilyl)>-2-epiavermectin B1a

4'',5-bis<O-(dimethyl-tert-butylsilyl)>-2-epiavermectin B1a

下游产品

共找到2个下游商品 >

Δ2-4(R)-avermectin B1a

Δ2-4(R)-avermectin B1a

阿维菌素

上游原料

4'',5,7-tris[O-(trimethylsilyl)]-Δ2-4(R)-avermectin B1a <2S(2R,4E,6S,7S)>-2-<2-(tert-butyldimethylsilyloxy)-6-(tert-butyldiphenylsilyloxy)-5,7-dimethylnona-4,8-dienyl>oxirane <2R(2E,4S,5S),4S,6S,8R(S),9S>-2-<4-hydroxy-3,5-dimethylhepta-2,6-dienyl>-9-methyl-8-(1-methypropyl)-1,7-dioxaspiro<5.5>undec-10-en-4-ol (2S,3S,E)-6-((2R,4S,6S,8R,9S)-8-((S)-sec-butyl)-4-((tert-butyldimethylsilyl)oxy)-9-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl)-3-((tert-butyldimethylsilyl)oxy)-2,4-dimethylhex-4-en-1-ol (1S,2S,3S,5S,6S)-3-[(tert-butyldiphenylsilyloxy)methyl]-5-methyl-2-[1-methylene-3-(phenylsulphonyl)propyl]-7-oxabicyclo[4.1.0]heptan-2-ol 4'',5-bis<O-(dimethyl-tert-butylsilyl)>-2-epiavermectin B1a (1E,3S,4S)-1-bromo-2,4-dimethylhexa-1,5-dien-3-ol (1S,2S,3R,4S,6S)-6-[(tert-butyldiphenylsilyloxy)methyl]-4-methyl-1-[1-methylene-3-(phenylsulphonyl)propyl]cyclohexane-1,2,3-triol (3E<2E,4S,5S,6E,8<2R,4S,6S,8R(S),9S>>,3aS,4S,6S,7R,7aR)-octahydro-3a,7-dihydroxy-3-<5-hydroxy-8-<4-hydroxy-9-methyl-8-(1-methylpropyl)-1,7-dioxaspiro<5.5>undec-10-en-2-yl>-4,6-dimethylocta-2,6-dienylidene>-6-methylbenzofuran-4-carbaldehyde (3S,4R,5S)-3,5-dimethylhept-1-yn-4-ol (3S,4S)-4-methylhexane-1,3-diol (1S,2R,3R,4S,6S)-3-(tert-butyldimethylsilyloxy)-6-[(tert-butyldiphenylsilyloxy)methyl]-4-methyl-1-[1-methylene-3-(phenylsulphonyl)propyl]cyclohexane-1,2-diol (1S,4S,6S)-6-[(tert-butyldiphenylsilyloxy)methyl]-4-methyl-1-[1-methylene-3-(phenylthio)propyl]cyclohex-2-enol (1S,3S,5S,6S)-3-((tert-butyldiphenylsilyloxy)methyl)-5-methyl-7-oxabicyclo(4.1.0)heptan-2-one (3E<2E,4S,5S,6E,8<2R,4S,6S,8R(S),9S>>,3aS,4S,6S,7R,7aR)-octahydro-3a,7-dihydroxy-3-<5-hydroxy-8-<4-hydroxy-9-methylpropyl)-1,7-dioxaspiro<5.5>undec-10-en-2-yl>-4,6-dimethylocta-2,6-dienylidene>-6-methylbenzofuran-4-carboxylic acid (2R,3R,4S)-3-(methoxymethoxy)-2,4-dimethylhexanal (4S)-5-dehydroxy-3,4-dihydro-5-oxoavermectin B1a aglycone (1S,2S,3R,4S,6S)-3-(tert-butyldimethylsilyloxy)-6-((tert-butyldiphenylsilyloxy)methyl)-4-methyl-1-(1-methylene-3-(phenylsulphonyl)propyl)cyclohexane-1,2-diol 5,4''-bis-O-(tert-butyldimethylsilyl)avermectin B2a (1S,2S,3S,5S,6S)-3-((tert-butyldiphenylsilyloxy)methyl)-5-methyl-2-(1-methylene-3-(phenylthio)propyl)-7-oxabicyclo(4.1.0)heptan-2-ol Δ2-4(R)-avermectin B1a 4'',5-bis<O-(dimethyl-tert-butylsilyl)>-Δ2-4(R)-avermectin B1a 2-((2R,4S,6S,8R,9S)-4-(benzyloxy)-8-((S)-sec-butyl)-9-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl)ethan-1-ol [1R(S),2R,3R,4S,6S]-3-(tert-butyldimethylsilyloxy)-6-[(tert-butyldiphenylsilyloxy)methyl]-1-[1-hydroxymethyl-3-(phenylsulphonyl)propyl]-4-methylcyclohexane-1,2-diol [2R(2E,4S,5S),4S,6S,8R(S),9S]-4-(tert-butyldimethylsilyloxy)-2-[4-(tert-butyldimethylsilyloxy)-3,5-dimethylhepta-2,6-dienyl]-9-methyl-8-(1-methypropyl)-1,7-dioxaspiro[5.5]undec-10-en-4-ol <2S,3S,4E,6<2R,4S,6S,8R(S),9S>>-3-(tert-butyldimethylsilyloxy)-6-<4-(tert-butyldimethylsilyloxy)-9-methyl-8-(1-methypropyl)-1,7-dioxaspiro<5.5>undec-10-en-2-yl>-2,4-dimethylhex-4-enal O-(4-O-L-oleandrosyl-L-oleandrosyl)imidazole-1-thiocarboxylate 5,4''-bis-O-(tert-butyldimethylsilyl)-23-O-(methanesulfonyl)avermectin B2a 阿维菌素 (1E,3S,4S)-1-bromo-3-(tert-butyldiphenylsilyloxy)-2,4-dimethylhexa-1,5-diene (1S,4S,6S)-6-[(tert-butyldiphenylsilyloxy)methyl]-4-methyl-1-[1-methylene-3-(phenylsulphonyl)propyl]cyclohex-2-enol [2RS,3S,4S,5E,7[2R,4S,6S,8R(S),9S]]-4-(tert-butyldimethylsilyloxy)-7-[4-(tert-butyldimethylsilyloxy)-9-methyl-8-(1-methypropyl)-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-3,5-dimethylhept-5-ene-1,2-diol methyl (3aR,6S,7R,7aR,E)-3-((2E,4S,5S,6E)-8-((2R,4S,6S,8R,9S)-8-((S)-sec-butyl)-4-hydroxy-9-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl)-5-hydroxy-4,6-dimethylocta-2,6-dien-1-ylidene)-3a,7-dihydroxy-6-methyl-2,3,3a,6,7,7a-hexahydrobenzofuran-4-carboxylate (((3S,4R,5S)-3,5-dimethylhept-1-yn-4-yl)oxy)trimethylsilane (2S,3S,5S,6R)-6-(tert-butyldimethylsilyloxy)-3-[(tert-butyldiphenylsilyloxy)methyl]-2-hydroxy-5-methyl-2-[1-methylene-3-(phenylsulphonyl)propyl]cyclohexanone 4'',5-di-O-tert-butyldimethylsilyl-22,23-dihydroavermectin B1 (4S)-3,4-dihydroavermectin B1a aglycone 4'',5,7-tris-O-trimethylsilyl-avermectin B1 (3S,4R,5S)-4-(methoxymethoxy)-3,5-dimethylhept-1-yne avermectin B1a aglycon 5-tert-butyldimethylsilyl ether avermectin B1a aglycone (3E<2E,4S,5S,6E,8<2R,4S,6S,8R(S),9S>>,3aS,4S,6S,7R,7aR)-octahydro-4-(hydroxymethyl)-3-<5-hydroxy-8-<4-hydroxy-9-methyl-8-(1-methylpropyl)-1,7-dioxaspiro<5.5>undec-10-en-2-yl>-4,6-dimethylocta-2,6-dienylidene>-6-methylbenzofuran-3a,7-diol 4'',5-bis(O-(dimethyl-tert-butylsilyl))-7-O-(trimethylsilyl)-Δ2-4(R)-avermectin B1a (1S,2S,3R,4S,6S)-6-(hydroxymethyl)-4-methyl-1-(1-methylene-3-(phenylsulphonyl)propyl)cyclohexane-1,2,3-triol (4S,6S)-6-<(tert-butyldiphenylsilyloxy)methyl>-4-methylcyclohex-2-enone (2S,3R,4S)-2,4-dimethyl-1,3-hexanediol

下游产品

Δ2-4(R)-avermectin B1a 阿维菌素