化合物简介
Isoxicam is a nonsteroidal anti-inflammatory drug (NSAID) that was taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. The drug was introduced in 1983 by the Warner-Lambert Company. Isoxicam is a chemical analog of Piroxicam (Feldene)which has a pyridine ring in lieu of an isoxazole ring. In 1985 Isoxicam was withdrawn from the French market, due to adverse effects, namely Toxic Epidermal Necrolysis (Lyell syndrome)resulting in death. Although these serious side affects were observed only in France, the drug was withdrawn worldwide.
基本信息
中文名称
伊索昔康
英文名称
isoxicam
中文别名
异恶噻酰胺、埃索昔康
英文别名
Isoxicamo、Isoxicamo [INN-Spanish]、N-(5-methyl-3-isoxazolyl)-4-hydroxy-2-methyl-2H-1,2-benzthiazine-3-carboxamide 1,1-dioxide、Pacyl (antiinflammatory)、Isoxicamum [INN-Latin]、4-hydroxy-2-methyl-N-(5-methylisoxazol-3-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide、Maxicam、EINECS 252-084-5、4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide、4-hydroxy-2-methyl-N-(5-methyl-1,2-oxazol-3-yl)-1,1-dioxo-1λ<sup>6</sup>,2-benzothiazine-3-carboxamide、4-Hydroxy-2-methyl-N-(5-methyl-3-isoxazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide、UNII-8XU734C4NG、Isoxicamum
CAS号
34552-84-6
分子式
C14H13N3O5S
分子量
335.335
精确质量
335.058
PSA
121.12
LOGP
2.5741
编号系统
UNII
8XU734C4NG
物化性质
密度
1.575g/cm3
沸点
518.8ºC at 760mmHg
闪点
267.5ºC
折射率
1.686
安全信息
RTECS号
DL0703000
WGK Germany
2
合成路线
59826-56-1
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