加奈索酮

CAS号：38398-32-2

英文名：1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone

分子式

C22H36O2

熔点

密度

1.036g/cm3

分子量

332.52

沸点

434.8ºC at 760mmHg

溶解度

信号词

危险品标志

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化合物简介

Ganaxolone (INN, also known as CCD-1042 and 3α-Hydroxy-3β-methyl-5α-pregnan-20-one) is a CNS-selective GABAA modulator that acts on well-characterized targets in the brain known to have anxiolytic and anticonvulsant effects. Ganaxolone protects against seizures in diverse animal models, including the pentylenetetrazol, 6Hz and amygdala kindling models. Ganaxolone is a positive allosteric modulator of the action of the GABAA receptor and, unlike benzodiazepines, there does not appear to be tolerance to the anticonvulsant effects of ganaxolone.

基本信息

中文名称

加奈索酮

英文名称

1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone

中文别名

英文别名

CCD-1042、GANAXOLONE

CAS号

38398-32-2

分子式

C22H36O2