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p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<((2S)-N-p-nitrobenzyloxycarbonylazeitidin-2-yl)acetylthio>-2-oxoazetidin-1-yl>-2-hydroxyacetate

p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<((2S)-N-p-nitrobenzyloxycarbonylazeitidin-2-yl)acetylthio>-2-oxoazetidin-1-yl>-2-hydroxyacetate

CAS号：105420-49-3

英文名：p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<((2S)-N-p-nitrobenzyloxycarbonylazeitidin-2-yl)acetylthio>-2-oxoazetidin-1-yl>-2-hydroxyacetate

分子式：C33H42N4O12SSi

分子量：746.857

合成路线

(2S,5R,6S)-6-Bromo-6-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid methyl ester

(2S,5R,6S)-6-Bromo-6-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid methyl ester

p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<((2S)-N-p-nitrobenzyloxycarbonylazeitidin-2-yl)acetylthio>-2-oxoazetidin-1-yl>-2-hydroxyacetate

p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<((2S)-N-p-nitrobenzyloxycarbonylazeitidin-2-yl)acetylthio>-2-oxoazetidin-1-yl>-2-hydroxyacetate

4-乙酰氧基氮杂环丁酮

4-乙酰氧基氮杂环丁酮

p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<((2S)-N-p-nitrobenzyloxycarbonylazeitidin-2-yl)acetylthio>-2-oxoazetidin-1-yl>-2-hydroxyacetate

p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<((2S)-N-p-nitrobenzyloxycarbonylazeitidin-2-yl)acetylthio>-2-oxoazetidin-1-yl>-2-hydroxyacetate

(S)-2-Carboxymethyl-azetidine-1-carboxylic acid 4-nitro-benzyl ester

(S)-2-Carboxymethyl-azetidine-1-carboxylic acid 4-nitro-benzyl ester

p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<((2S)-N-p-nitrobenzyloxycarbonylazeitidin-2-yl)acetylthio>-2-oxoazetidin-1-yl>-2-hydroxyacetate

p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<((2S)-N-p-nitrobenzyloxycarbonylazeitidin-2-yl)acetylthio>-2-oxoazetidin-1-yl>-2-hydroxyacetate

<(2R)-N-p-nitrobenzyloxycarbonylazetidin-2-yl>thioacetic S-acid

<(2R)-N-p-nitrobenzyloxycarbonylazetidin-2-yl>thioacetic S-acid

p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<((2S)-N-p-nitrobenzyloxycarbonylazeitidin-2-yl)acetylthio>-2-oxoazetidin-1-yl>-2-hydroxyacetate

p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<((2S)-N-p-nitrobenzyloxycarbonylazeitidin-2-yl)acetylthio>-2-oxoazetidin-1-yl>-2-hydroxyacetate

上游原料

<(2R)-N-p-nitrobenzyloxycarbonylazetidin-2-yl>thioacetic S-acid (2S,5R,6S)-6-Bromo-6-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid methyl ester 4-乙酰氧基氮杂环丁酮 (S)-2-Carboxymethyl-azetidine-1-carboxylic acid 4-nitro-benzyl ester

下游产品

p-nitrobenzyl 2-<(3S,4R)-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-4-<((2S)-N-p-nitrobenzyloxycarbonylazeitidin-2-yl)acetylthio>-2-oxoazetidin-1-yl>-2-triphenylphosphoranylideneacetate p-nitrobenzyl (5R,6S)-6-<(1R)-hydroxyethyl>-2-<<(2S)-N-p-nitrobenzyloxycarbonylazeitidin-2-yl>methyl>-2-penem-3-carboxylate (5R,6S)-6-<(1R)-hydroxyethyl>-2-<<(2S)-azeitidin-2-yl>methyl>-2-penem-3-carboxylic acid p-nitrobenzyl (5R,6S)-6-<(1R)-(tert-butyldimethylsilyloxy)ethyl>-2-<(2S)-N-p-nitrobenzyloxycarbonylazeitidin-2-yl>methyl-2-penem-3-carboxylate