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4-乙酰氧基氮杂环丁酮

4-乙酰氧基氮杂环丁酮

CAS号：76855-69-1

英文名：4-acetoxyazetidin-2-one

分子式

C13H25NO4Si

熔点

107-109°C(lit.)

密度

1.039g/cm3

分子量

287.427

沸点

358.318ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

An acetoxyazetidinone derivative used as an intermediate in the preparation of carbapenem antibiotics.

基本信息

中文名称

4-乙酰氧基氮杂环丁酮

英文名称

4-acetoxyazetidin-2-one

中文别名

(3R,4R)-4-乙酰氧基-3-[(R)-叔丁基二甲硅氧基)乙基]-2-氮杂环丁酮、AOSA(4-AA)、(3R,4R)-3-(R)-1-叔丁基二甲基硅氧乙基-4-乙酰氧基氮杂环丁-2-酮、氮杂环酮、氮杂环酮 4-AA 、 ACETOXYAZETIDINONE、(3R,4R)-4-乙酰氧基-3-[(R)-1-(叔丁基二甲基硅氧基)乙基]-2-氮杂环丁酮、[3R(1\'R,4R)]-(+)-4-乙酰氧基-3-[1-(叔丁基二甲基硅氧基)乙基]-2-氮杂环丁酮、2-氮杂环丁酮,4-乙酰氧基-3-[(1R)-1-[[(1,1-二甲基乙、4-乙酰氧基-3-[1-(叔丁基二甲基硅氧基)乙基]氮杂环丁酮、氮杂环酮 4-AA

英文别名

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one

CAS号

76855-69-1

分子式

C13H25NO4Si

分子量

287.427

精确质量

287.155

PSA

64.63

LOGP

2.3607

编号系统

MDL号

MFCD00077636

EINECS号

408-050-9

PubChem号

24863408

物化性质

外观与性状

白色至淡黄色晶体粉末

密度

1.039g/cm3

沸点

358.318ºC at 760 mmHg

熔点

107-109°C(lit.)

闪点

170.505ºC

折射率

1.464

储存条件

2-8ºC

安全信息

安全说明

S24-S26-S37-S61

危险类别码

R36; R43; R51/53

WGK Germany

2

危险品运输编码

UN 3077 9/PG 3

海关编码

2933990090

危险品标志

Xi

合成路线

共找到141条合成路线 >

83247-78-3

4-乙酰氧基氮杂环丁酮

4-乙酰氧基氮杂环丁酮

海关数据

共找到1个国家海关数据 >

国家/地区名称	海关编码	更新时间	操作
中国	2933990090	2019-03	查看

上游原料

共找到7个上游原料 >

(1R)-1-[(2S,3S)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-(diphenylmethyl)-4-oxoazetidin-3-yl]ethyl acetate

(1R)-1-[(2S,3S)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-(diphenylmethyl)-4-oxoazetidin-3-yl]ethyl acetate

(3S,4R)-3-[(R)-1-Hydroxyethyl]-1-(1-methoxycarbonyl-2-methylprop-1-enyl)-4-methylthioazetidin-2-one

(3S,4R)-3-[(R)-1-Hydroxyethyl]-1-(1-methoxycarbonyl-2-methylprop-1-enyl)-4-methylthioazetidin-2-one

(1R)-1-[(2S,3S)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-(diphenylmethyl)-4-oxoazetidin-3-yl]ethyl benzoate

(1R)-1-[(2S,3S)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-(diphenylmethyl)-4-oxoazetidin-3-yl]ethyl benzoate

(2S,5R,6S)-6-Bromo-6-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid methyl ester

(2S,5R,6S)-6-Bromo-6-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid methyl ester

Butanoic acid, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (3R)-

Butanoic acid, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (3R)-

(1S,3R,5R,6R)-8-aza-3-(benzyloxymethyl)-5-methyl-2,4-dioxa-bicyclo<4.2.0>octan-7-one

(1S,3R,5R,6R)-8-aza-3-(benzyloxymethyl)-5-methyl-2,4-dioxa-bicyclo<4.2.0>octan-7-one

下游产品

共找到141个下游商品 >

allyl (1S,5S,8aS,8bR)-1-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-5-isopropoxy-2-oxo-1,2,5,6,7,8,8a,8b-octahydroazeto[2,1-a]isoindole-4-carboxylate

allyl (1S,5S,8aS,8bR)-1-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-5-isopropoxy-2-oxo-1,2,5,6,7,8,8a,8b-octahydroazeto[2,1-a]isoindole-4-carboxylate

(1S,6S,8aS,8bR)-1-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-(2-methoxy-ethyl)-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylic acid benzyl ester

(1S,6S,8aS,8bR)-1-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-(2-methoxy-ethyl)-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylic acid benzyl ester

(3S)-3-[(1S)-1-(benzoyloxy)ethyl]azetidin-2-one

(3S)-3-[(1S)-1-(benzoyloxy)ethyl]azetidin-2-one

{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-[(1R,4R)-4-(2-methoxy-ethyl)-2-oxo-cyclohexyl]-4-oxo-azetidin-1-yl}-oxo-acetic acid benzyl ester

{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-[(1R,4R)-4-(2-methoxy-ethyl)-2-oxo-cyclohexyl]-4-oxo-azetidin-1-yl}-oxo-acetic acid benzyl ester

(3S,4S)-4-(1-methylallenyl)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone

(3S,4S)-4-(1-methylallenyl)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone

(5R,6S)-6-<(1R)-hydroxyethyl>-2-(3-aminopropan-1-yl)-2-penem-3-carboxylic acid

(5R,6S)-6-<(1R)-hydroxyethyl>-2-(3-aminopropan-1-yl)-2-penem-3-carboxylic acid

上游原料

(1R)-1-[(2S,3S)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-(diphenylmethyl)-4-oxoazetidin-3-yl]ethyl acetate (3S,4R)-3-[(R)-1-Hydroxyethyl]-1-(1-methoxycarbonyl-2-methylprop-1-enyl)-4-methylthioazetidin-2-one (1R)-1-[(2S,3S)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-(diphenylmethyl)-4-oxoazetidin-3-yl]ethyl benzoate (2S,5R,6S)-6-Bromo-6-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid methyl ester (1S,3R,5R,6R)-8-aza-3-(benzyloxymethyl)-5-methyl-2,4-dioxa-bicyclo<4.2.0>octan-7-one

下游产品

allyl (1S,5S,8aS,8bR)-1-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-5-isopropoxy-2-oxo-1,2,5,6,7,8,8a,8b-octahydroazeto[2,1-a]isoindole-4-carboxylate (1S,6S,8aS,8bR)-1-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-6-(2-methoxy-ethyl)-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylic acid benzyl ester (3S)-3-[(1S)-1-(benzoyloxy)ethyl]azetidin-2-one {(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-[(1R,4R)-4-(2-methoxy-ethyl)-2-oxo-cyclohexyl]-4-oxo-azetidin-1-yl}-oxo-acetic acid benzyl ester (3S,4S)-4-(1-methylallenyl)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone (5R,6S)-6-<(1R)-hydroxyethyl>-2-(3-aminopropan-1-yl)-2-penem-3-carboxylic acid (3S,4R)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-[2-(trimethylsilyl)ethylseleno]-2-azetidinone (2S,2aS,2bS)-2-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-oxo-2,2a,2b,3,5,6-hexahydro-1H-4-thia-7a-aza-cyclobuta[a]indene-7-carboxylic acid allyl ester (3S,4S)-3-((R)-(1-(tert-butyldimethylsilyl)oxy)ethyl)-4-((3S)-4-oxotetrahydro-4H-thiopyrane-3-yl)azetidine-2-one ethyl 4-((2R,3S)-3-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-4-oxoazetidin-2-yl)but-2-ynoate (5R,6S)-6-((R)-1-hydroxyethyl)-2-[(1-tetrahydro-2-furyl)ethyl]penem-3-carboxylic acid allyl ester benzyl 7α-<(1R)-1-hydroxyethyl>-2-oxo-1-oxa-3-cephem-4-carboxylate 2-Allyl-2-{(2S,3S)-1-allyloxyoxalyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-malonic acid diethyl ester (5R,6S)-3-tert-Butyl-6-((R)-1-hydroxy-ethyl)-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester (3S,4S)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-[1,1-di(allyloxycarbonyl)ethyl]-2-azetidinone allyl (1S,5S,8aS,8bR)-1-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-5-ethoxy-2-oxo-1,2,5,6,7,8,8a,8b-octahydroazeto[2,1-a]isoindole-4-carboxylate (R)-2-{(2S,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-thiopropionic acid S-(2-diethylcarbamoyl-phenyl) ester [(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(2,2-dimethyl-thiopropionylsulfanyl)-4-oxo-azetidin-1-yl]-oxo-acetic acid 4-nitro-benzyl ester p-nitrobenzyl 2-<(3S,4R)-3-<(R)-1-(t-butyldimethylsilyloxy)ethyl>-4-<4-(p-nitrobenzyloxycarbonylamino)-2-oxobutyl>-2-oxo-1-azetidinyl>-2-triphenylphosphoranylideneacetate {(2R,3S)-2-Benzoylsulfanyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-1-yl}-oxo-acetic acid allyl ester tert-butyl 4-{[(2R,3S)-3-{(1R)-1-{[tert-butyl-(dimethyl)-silyl]-oxy}-ethyl}-4-oxoazetidin-2-yl]-acetyl}-phenyl carbamate (2aS,2bS,5aS,6R)-2-Eth-(Z)-ylidene-2b-methyl-1,4-dioxo-octahydro-3-oxa-6a-aza-cyclobuta[a]pentalene-6-carboxylic acid benzyl ester (5R,6S)-6-<(1R)-hydroxyethyl>-2-(2-aminoethyl)-2-penem-3-carboxylic acid 1-{(2S,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-2-oxo-cyclohex-3-enecarboxylic acid allyl ester allyl (5S,6S,7S)-5-[(R)-1-hydroxyethyl]-4-oxo-9-thia-3-azatricyclo[5.4.0.03,6 ]undec-1-ene-2-carboxylate <3S-<3α(S*),4β>>-methyl 3-(1-t-butyldimethylsilyloxyethyl)-2-azetidinone-4-carboxylate (2S,2aS,2bR)-2-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-oxo-2,2a,2b,3,5,6-hexahydro-1H-4-thia-7a-aza-cyclobuta[a]indene-7-carboxylic acid allyl ester 4-nitrobenzyl (4-{[(2R,3S)-3-((1R)-1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-4-oxoazetidin-2-yl]acetyl}-2-chlorophenyl)acetate [(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-((S)-4-oxo-tetrahydro-thiopyran-3-yl)-azetidin-1-yl]-oxo-acetic acid allyl ester 2-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3,4-dihydro-2H-acridin-1-one {(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-thioacetic acid S-isopropyl ester (5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-7-oxo-3-(S)-tetrahydro-furan-2-yl-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid allyl ester (5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(2-ethoxy-ethylsulfanyl)-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester (5R,6S)-3-(2-Ethoxy-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester (3S,4R)-4-[1-Buten-3(S)-yl]-3-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone (3S,4R)-3-[(R)-1-Hydroxyethyl]-4-[(phenylthio)carbonylmethyl]-2-azetidinone (3S,4R)-3-((1R)-1-{[tert-butyl-(dimethyl)-silyl]-oxy}-ethyl)-4-[2-(3-{[tert-butyl-(dimethyl)-silyl]-oxy}-phenyl)-2-oxoethyl]-azetidin-2-one (3S,4S)-3-((R)-(1-(tert-butyldimethylsilyl)oxy)ethyl)-4-((3R)-4-oxotetrahydro-4H-thiopyrane-3-yl)azetidine-2-one allyl (1S,5S,8aS,8bR)-5-ethoxy-1-((R)-1-hydroxyethyl)-2-oxo-1,2,5,6,7,8,8a,8b-octahydroazeto[2,1-a]isoindole-4-carboxylate (3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-((S)-1-methyl-2-trityloxymethyl-allyl)-azetidin-2-one (2S,2aS,2bR)-2-((R)-1-Methanesulfonyloxy-ethyl)-1-oxo-2,2a,2b,3,5,6-hexahydro-1H-4-thia-7a-aza-cyclobuta[a]indene-7-carboxylic acid allyl ester (3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-but-2-ynyl-azetidin-2-one 4-Nitrobenzyl (2-{[(allyloxy)carbonyl]amino}-4-{[(2R,3S)-3-((1R)-1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-4-oxoazetidin-2-yl]acetyl}phenyl)acetate (5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-methyl-1-aza-bicyclo[3.2.0]hept-2-en-7-one [(3S,4S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-((R)-4-oxo-tetrahydro-thiopyran-3-yl)-azetidin-1-yl]-oxo-acetic acid allyl ester (3S,4R)-4-[4-(allyloxycarbonyl)-1-benzyl-3-oxopiperidin-4-yl]-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone allyl (5S,6S,7R)-5-[(R)-1-hydroxyethyl]-4-oxo-9-thia-3-azatricyclo[5.4.0.03,6 ]undec-1-ene-2-carboxylate (5R,6S)-6-<(1R)-hydroxyethyl>-2-<(2R)-pyrrolidin-2-yl>-2-penem-3-carboxylic acid