普乐沙福

普乐沙福

CAS号：110078-46-1

英文名：Plerixafor

分子式

C28H54N8

熔点

密度

0.962

分子量

502.782

沸点

657.5ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Plerixafor is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).

基本信息

中文名称

普乐沙福

英文名称

Plerixafor

中文别名

MOZOBIL PLERIXAFOR

英文别名

Mozobil、Unii-S915p5499n、1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene、Sdz sid 791

CAS号

110078-46-1

分子式

C28H54N8

分子量

502.782

精确质量

502.447

PSA

78.66

LOGP

2.2644

编号系统

MDL号

MFCD05662218

物化性质

密度

0.962

沸点

657.5ºC at 760 mmHg

闪点

361.8ºC

蒸汽压

1.06E-34mmHg at 25°C

安全信息

海关编码

2933990090

合成路线

1-(4,8-bis-(2,2,2-trifluoroacetyl)-11-{4-[4,8,11-tris-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-ylmethyl]-benzyl}-1,4,8,11-tetraazacyclotetradec-1-yl)-2,2,2-trifluoroethanone

1-(4,8-bis-(2,2,2-trifluoroacetyl)-11-{4-[4,8,11-tris-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-ylmethyl]-benzyl}-1,4,8,11-tetraazacyclotetradec-1-yl)-2,2,2-trifluoroethanone

普乐沙福

上游原料

共找到9个上游原料 >

1,1'-p-xylylbis<4,8,11-tris(tert-butyloxycarbonyl)-1,4,8,11-tetraazacyclotetradecane>

1,1'-p-xylylbis<4,8,11-tris(tert-butyloxycarbonyl)-1,4,8,11-tetraazacyclotetradecane>

(R)-N-(1-phenylpropyl)formamide

(R)-N-(1-phenylpropyl)formamide

1-[4,8-bis(2,2,2-trifluoroacetyl)-1,4,8,11-tetrazacyclotetradec-1-yl]-2,2,2-trifluoroethanone

1-[4,8-bis(2,2,2-trifluoroacetyl)-1,4,8,11-tetrazacyclotetradec-1-yl]-2,2,2-trifluoroethanone

Cyclamphosphine oxide

Cyclamphosphine oxide

1,4,8-三(叔丁氧碳酰)-1,4,8,11-四氮杂环十四烷

1,4,8-三(叔丁氧碳酰)-1,4,8,11-四氮杂环十四烷

1-(4,8-bis-(2,2,2-trifluoroacetyl)-11-{4-[4,8,11-tris-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-ylmethyl]-benzyl}-1,4,8,11-tetraazacyclotetradec-1-yl)-2,2,2-trifluoroethanone

1-(4,8-bis-(2,2,2-trifluoroacetyl)-11-{4-[4,8,11-tris-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-ylmethyl]-benzyl}-1,4,8,11-tetraazacyclotetradec-1-yl)-2,2,2-trifluoroethanone

上游原料

1,1'-p-xylylbis<4,8,11-tris(tert-butyloxycarbonyl)-1,4,8,11-tetraazacyclotetradecane> (R)-N-(1-phenylpropyl)formamide 1-[4,8-bis(2,2,2-trifluoroacetyl)-1,4,8,11-tetrazacyclotetradec-1-yl]-2,2,2-trifluoroethanone Cyclamphosphine oxide 1,4,8-三(叔丁氧碳酰)-1,4,8,11-四氮杂环十四烷 1-(4,8-bis-(2,2,2-trifluoroacetyl)-11-{4-[4,8,11-tris-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-ylmethyl]-benzyl}-1,4,8,11-tetraazacyclotetradec-1-yl)-2,2,2-trifluoroethanone 1,4,8,11-四氮杂环十四烷顺式-十氢-1H,6H-3α,5α,8α,10α-四氮杂芘 1,4-二(溴甲基)苯