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20R-喜树碱

20R-喜树碱

CAS号：110351-92-3

英文名：(R)-(-)-Camptothecin

分子式

C20H16N2O4

熔点

密度

1.51g/cm3

分子量

348.352

沸点

757ºC at 760mmHg

溶解度

信号词

危险品标志

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化合物简介

Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent.

基本信息

中文名称

20R-喜树碱

英文名称

(R)-(-)-Camptothecin

中文别名

英文别名

20R-Camptothecin

CAS号

110351-92-3

分子式

C20H16N2O4

分子量

348.352

精确质量

348.111

PSA

81.42

LOGP

2.0796

物化性质

密度

1.51g/cm3

沸点

757ºC at 760mmHg

闪点

411.6ºC

折射率

1.746

蒸汽压

4.39E-24mmHg at 25°C

合成路线

4-ethyl-1,12-dihydro-14H-pyrano[3',4':6,7indolizino[1,2-b]]quinolin-14-one

4-ethyl-1,12-dihydro-14H-pyrano[3',4':6,7indolizino[1,2-b]]quinolin-14-one

20R-喜树碱

喜树碱

上游原料

共找到31个上游原料 >

4-iodo-2-methoxy-6-trimethylsilanyl-3-pyridinecarboxaldehyde

4-iodo-2-methoxy-6-trimethylsilanyl-3-pyridinecarboxaldehyde

2-(methoxycarbonyl)-2-(methoxymethoxy)butanoic acid

2-(methoxycarbonyl)-2-(methoxymethoxy)butanoic acid

4-ethyl-1,12-dihydro-14H-pyrano[3',4':6,7indolizino[1,2-b]]quinolin-14-one

4-ethyl-1,12-dihydro-14H-pyrano[3',4':6,7indolizino[1,2-b]]quinolin-14-one

3-Methoxymethyl-quinoline-2-carboxylic acid methyl ester

3-Methoxymethyl-quinoline-2-carboxylic acid methyl ester

乙基丙二酸二甲酯

乙基丙二酸二甲酯

(S)-4-ethyl-4-hydroxy-6-iodo-3-oxo-1H-pyrano[3,4-c]-8-pyridone

(S)-4-ethyl-4-hydroxy-6-iodo-3-oxo-1H-pyrano[3,4-c]-8-pyridone

上游原料

4-iodo-2-methoxy-6-trimethylsilanyl-3-pyridinecarboxaldehyde 2-(methoxycarbonyl)-2-(methoxymethoxy)butanoic acid 4-ethyl-1,12-dihydro-14H-pyrano[3',4':6,7indolizino[1,2-b]]quinolin-14-one 3-Methoxymethyl-quinoline-2-carboxylic acid methyl ester 乙基丙二酸二甲酯 (S)-4-ethyl-4-hydroxy-6-iodo-3-oxo-1H-pyrano[3,4-c]-8-pyridone 4'-ethyl-1',4',7',8'-tetrahydro-4'-hydroxy-3'H,10'H-spiro[1,3-dioxolane-2,6'-pyrano[3,4-f]indolizine]-3',10'-dione (S)-4-ethyl-4-hydroxy-6-iodo-8-methoxy-1,4-dihydro-pyrano[3,4-c]pyridin-3-one 2-甲氧基-6-(三甲基硅烷基)吡啶 4-ethyl-8-methoxy-6-(trimethylsilyl)-1H-pyrano[3,4-c]pyridine methyl 4-ethyl-8-methoxy-1H-pyrano[3,4-c]pyridine-6-carboxylate (S)-(+)-4-ethyl-4-hydroxy-8-methoxy-6-(trimethylsilyl)-1,4-dihydro-3H-pyrano[3,4-c]pyridin-3-one methyl 4-ethyl-8-oxo-7,8-dihydro-1H-pyrano[3,4-c]pyridine-6-carboxylate 4-ethyl-6-chloro-8-methoxy-1H-pyrano[3,4-c]pyridine 2-methoxy-6-(trimethylsilyl)nicotinaldehyde 2-氯-3-甲基喹啉 dimethyl 2-ethyl-2-hydroxymalonate methyl 3-methylquinoline-2-carboxylate (S)-4-Ethyl-4-hydroxy-6-iodo-3-oxo-7-propargyl-1H-pyrano[3,4-c]-8-pyridone dimethyl [2-[3-(methoxymethyl)quinolin-2-yl]-2-oxoethyl]phosphonate phenyl isocyanate 5'(R)-1,5-dioxo-5'-ethyl-5'-hydroxy-2'H,5'H,6'H-6'-oxopyrano[3',4'-f]Δ6,8-tetrahydroindolizine 4-ethyl-8-oxo-N-phenyl-7-(prop-2-ynyl)-7,8-dihydro-1H-pyrano[3,4-c]pyridine-6-carboxamide methyl 4-ethyl-8-oxo-7-(prop-2-ynyl)-7,8-dihydro-1H-pyrano[3,4-c]pyridine-6-carboxylate (R)-N,N-diethyl-2-formyl-2-(methoxymethoxy)butanamide 4-ethyl-8-oxo-7-(prop-2-ynyl)-7,8-dihydro-1H-pyrano[3,4-c]pyridine-6-carboxylic acid 2-Carbomethoxy-3-brommethylchinolin 2-氨基苯甲醛 methyl 2-(diethylcarbamoyl)-2-(methoxymethoxy)butanoate 2-(diethylcarbamoyl)-2-(methoxymethoxy)butanoic acid