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喜树碱

喜树碱

CAS号：7689-03-4

英文名：camptothecin

分子式

C20H16N2O4

熔点

260°C (dec.)(lit.)

密度

1.51 g/cm3

分子量

348.352

沸点

264ºC

溶解度

insoluble

信号词

Danger

危险品标志

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化合物简介

喜树碱(Camptothecin，CPT)，是一种细胞毒性喹啉类生物碱，能抑制DNA拓扑异构酶(TOPO I)。

基本信息

中文名称

喜树碱

英文名称

camptothecin

中文别名

(S)-4-乙基-4-羟基-1H-吡喃并[3\',4\':6,7]吲嗪并[1,2-b]喹啉-3,14-(4H,12H)-二酮、4-乙基-4-羟基-1H-吡喃[3\',4\'：6,7]氮茚[1,2]喹啉-3,14(4H,12H)-二酮

英文别名

Camptothecin、Baicalin std.、CAMPTOTHECINE、CaMpathecin、(S)-4-ethyl-4-hydroxy-1H-pyrano-[3\',4\':6,7]indolizinol[1,2-b]quinoline-3,14(4H,12H)-dione、d-Camptothecin、(+)-Camptothecin、Camptohecin、CAMPTOTHECIN

CAS号

7689-03-4

分子式

C20H16N2O4

分子量

348.352

精确质量

348.111

PSA

81.42

LOGP

2.0796

编号系统

MDL号

MFCD00081076

物化性质

外观与性状

淡黄色晶体粉末

密度

1.51 g/cm3

沸点

264ºC

熔点

260°C (dec.)(lit.)

闪点

411.6ºC

折射率

1.787

水溶解性

insoluble

储存条件

库房低温通风干燥,与食品原料分开存放

安全信息

RTECS号

UQ0492000

安全说明

S45-S36/37/39-S26

危险类别码

R25

WGK Germany

3

危险品运输编码

UN 1544 6.1/PG 3

危险品标志

T

危险标志

GHS06

危险性描述

H301

信号词

Danger

生产方法及用途

用途

本品用于恶性肿瘤、银屑病、急慢性白血病以及血吸虫病引起的肝脾肿大等以及作为盐酸伊立替康的起始原料。

合成路线

共找到43条合成路线 >

(S)-7-((2-bromoquinolin-3-yl)methyl)-4-ethyl-4-hydroxy-1,7-dihydro-3H-pyrano[3,4-c]pyridine-3,8(4H)-dione

(S)-7-((2-bromoquinolin-3-yl)methyl)-4-ethyl-4-hydroxy-1,7-dihydro-3H-pyrano[3,4-c]pyridine-3,8(4H)-dione

喜树碱

上游原料

共找到158个上游原料 >

4-ethyl-1,12-dihydro-14H-pyrano[3',4':6,7indolizino[1,2-b]]quinolin-14-one

4-ethyl-1,12-dihydro-14H-pyrano[3',4':6,7indolizino[1,2-b]]quinolin-14-one

2-[(4-methylphenyl)iminomethyl]aniline

2-[(4-methylphenyl)iminomethyl]aniline

(S)-4-ethyl-4-hydroxy-6-iodo-8-methoxy-1,4-dihydro-pyrano[3,4-c]pyridin-3-one

(S)-4-ethyl-4-hydroxy-6-iodo-8-methoxy-1,4-dihydro-pyrano[3,4-c]pyridin-3-one

4-乙基-7,8-二氢-4-羟基-1H-吡喃并[3,4-f]吲嗪-3,6,10(4H)-三酮

4-乙基-7,8-二氢-4-羟基-1H-吡喃并[3,4-f]吲嗪-3,6,10(4H)-三酮

methyl 4-ethyl-8-oxo-7,8-dihydro-1H-pyrano[3,4-c]pyridine-6-carboxylate

methyl 4-ethyl-8-oxo-7,8-dihydro-1H-pyrano[3,4-c]pyridine-6-carboxylate

2-氯-6-甲氧基吡啶

2-氯-6-甲氧基吡啶

下游产品

共找到36个下游商品 >

10-氨基喜树碱

10-氨基喜树碱

7-(1-Hydroxy-2-propyl)camptothecin

7-(1-Hydroxy-2-propyl)camptothecin

(S)-4-Ethyl-4-hydroxy-11-(1-hydroxymethyl-propyl)-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione

(S)-4-Ethyl-4-hydroxy-11-(1-hydroxymethyl-propyl)-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione

9-硝基喜树碱

9-硝基喜树碱

7-(1-Hydroxy-2-propyl)camptothecin

7-(1-Hydroxy-2-propyl)camptothecin

喜树碱钠盐

喜树碱钠盐

上游原料

4-ethyl-1,12-dihydro-14H-pyrano[3',4':6,7indolizino[1,2-b]]quinolin-14-one 2-[(4-methylphenyl)iminomethyl]aniline (S)-4-ethyl-4-hydroxy-6-iodo-8-methoxy-1,4-dihydro-pyrano[3,4-c]pyridin-3-one 4-乙基-7,8-二氢-4-羟基-1H-吡喃并[3,4-f]吲嗪-3,6,10(4H)-三酮 methyl 4-ethyl-8-oxo-7,8-dihydro-1H-pyrano[3,4-c]pyridine-6-carboxylate 2-氯-6-甲氧基吡啶 (S)-α-ethyl-α-hydroxy-1,1-(ethylenedioxy)-6-hydroxymethyl-5-oxo-1,2,3,5-tetrahydroindolizine-7-[N-(1S)-1-phenylethyl]acetamide ethyl 3-(diethoxymethyl)-2,2-diethoxy-6-(3-(methoxymethyl)quinolin-2-yl)-1-(methylsulfonyl)-1,2,3,4-tetrahydropyridine-4-carboxylate (S)-4-Ethyl-4-hydroxy-6-iodo-3-oxo-7-propargyl-1H-pyrano[3,4-c]-8-pyridone phenyl isocyanate (4S)-4-乙基-4-羟基-1H-吡喃并[3,4-c]吡啶-3,8(4h,7h)-二酮 (S)-4-Ethyl-4-hydroxy-6-iodo-3-oxo-7-allyl-1H-pyrano[3,4-c]-8-pyridone (-)-O,21-dihydrocamptothecin (S)-4-ethyl-4-hexanoyloxy-1,12-dihydro-4H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione (4'S)-4'-ethyl-1',4',7',8'-tetrahydro-4'-hydroxy-3'H,10'H-spiro[1,3-dioxolane-2,6'-pyrano[3,4-f]indolizine]-3',10'-dione camptothecin 20-(5-bromo)-n-pentanoate methyl 4-ethyl-8-oxo-7-(prop-2-ynyl)-7,8-dihydro-1H-pyrano[3,4-c]pyridine-6-carboxylate 2-chloro-4-iodo-6-methoxy-5-(methoxymethyl)pyridine ethyl (E)-4-(3-(methoxymethyl)quinolin-2-yl)-4-oxobut-2-enoate 2-ethoxy-3-(ethoxymethyl)-6-[3-(methoxymethyl)quinolin-2-yl]isonicotinic acid ethyl ester N-甲基哌嗪 (+-)-9-氨基-4-乙基-4-羟基-1H-吡喃并[3',4':6,7]吲哚嗪并[1,2-b]喹啉3,14(4H,12H)-二酮 (S)-2-(6-chloro-2-methoxy-3-(methoxymethyl)pyridin-4-yl)-1-(((1R,2S,5R)-5-methyl-2-(2-phenylpropan-2-yl)cyclohexyl)oxy)-1-oxobutan-2-yl [1,1'-biphenyl]-4-carboxylate (S)-4-ethyl-4-hydroxy-6-iodo-3-oxo-1H-pyrano[3,4-c]-8-pyridone 4'-ethyl-1',4',7',8'-tetrahydro-4'-hydroxy-3'H,10'H-spiro[1,3-dioxolane-2,6'-pyrano[3,4-f]indolizine]-3',10'-dione 9-氨基喜树碱 methyl 4-ethyl-8-methoxy-1H-pyrano[3,4-c]pyridine-6-carboxylate 4-ethyl-6-chloro-8-methoxy-1H-pyrano[3,4-c]pyridine (S)-4-Ethyl-4-hydroxy-6-iodo-3-oxo-7-(4-chloro-2-butynyl)-1H-pyrano[3,4-c]-8-pyridone camptothecin 20-(2-bromo)-n-butyrate 托泊替康醋酸盐; 醋酸拓扑替康; 4-乙基-4,9-二羟基-10-[(二甲基氨基)甲基]-1H-吡喃并[3',4':6,7]中氮茚并[1,2-b]喹啉-3,14(4H,12H)-二酮醋酸盐 (2-氯-3-喹啉)甲醇 camptothecin 20-(4-bromo)-n-butyrate 2-(1,3-Dioxolan-2-yl)aniline ethyl (2E)-4-(3-(methoxymethyl)quinolin-2-yl)-4-((methylsulfonyl)imino)but-2-enoate 4(S)-4-ethyl-4-hydroxy-6-chloro-4,7-dihydro-1H-pyrano[3,4-c]pyridin-3,8-dione 4-ethyl-8-oxo-N-phenyl-7-(prop-2-ynyl)-7,8-dihydro-1H-pyrano[3,4-c]pyridine-6-carboxamide 2-氯喹啉 (+/-)-20-deoxycamptothecin 7-乙基-10-羟基喜树碱中间体 4-ethyl-8-oxo-7-(prop-2-ynyl)-7,8-dihydro-1H-pyrano[3,4-c]pyridine-6-carboxylic acid 1-[2-ethoxy-3-(ethoxymethyl)-6-[3-(methoxymethyl)quinolin-2-yl]pyridin-4-yl]propan-1-one 6-chloro-4-iodo-2-methoxy-3-pyridinecarboxaldehyde (R)-2-(8-(((tert-butyldimethylsilyl)oxy)methyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)-2-((trimethylsilyl)oxy)butanenitrile 2-氨基苯甲醛 2-chloro-3-(bromomethyl)quinoline

下游产品

10-氨基喜树碱 7-(1-Hydroxy-2-propyl)camptothecin (S)-4-Ethyl-4-hydroxy-11-(1-hydroxymethyl-propyl)-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione 9-硝基喜树碱 7-(1-Hydroxy-2-propyl)camptothecin 喜树碱钠盐喜树碱氮氧化物 AC1L3ZGZ 鲁比替康伊立替康 9-氨基喜树碱 9-甲氧基喜树碱 2-(氨甲基)苯乙酸盐酸盐 4-乙基-4-羟基-3,4,12,14-四氢-1H-吡喃并[3'4':6,7]吲哚嗪并[1,2-b]喹啉-3,14-二酮羟基喜树碱 O-乙酰基喜树碱 4-chloro-4-ethyl-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione 12-nitro-(20S)-camptothecin 7-乙基喜树碱 7-乙基-10-羟基喜树碱拓扑替康 7-甲基喜树碱麦皮星酮 (4S)-11-(Dimethoxymethyl)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]i ndolizino[1,2-b]quinoline-3,14(4H,12H)-dione 7-propyl-20(S)-camptothecin 10-羟基喜树碱 (S)-4-Ethyl-4-hydroxy-11-(4-hydroxy-butyl)-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione 9-甲氧基喜树碱 (4S)-4-ethyl-4-hydroxy-11-(4-hydroxybutan-2-yl)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (S)-9-acetoxy-4-ethyl-4-hydroxy-1,12-dihydro-4H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione 5-ethyl-5-hydroxy-1,4,5,13-tetrahydro-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione 7(3-Hydroxy-1-propyl)camptothecin 9-氮-10-羟基喜树碱 camptothecin-7-aldehyde AC1Q2RU2 7-(2-Hydroxyethyl)camptothecin