百科

2-羟基-4-氨基-5-羟甲基嘧啶

CAS号：1123-95-1

英文名：5-(hydroxymethyl)cytosine

分子式

C5H7N3O2

熔点

密度

1.65g/cm3

分子量

141.128

沸点

溶解度

信号词

危险品标志

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化合物简介

5-Hydroxymethylcytosine is a DNA pyrimidine nitrogen base. It is formed from the DNA base cytosine by adding a methyl group and then a hydroxy group. It is important in epigenetics, because the hydroxymethyl group on the cytosine can possibly switch a gene on and off. It was first seen in bacteriophages in 1952. However, in 2009 it was found to be abundant in human and mouse brains, as well as in embryonic stem cells. In mammals, it can be generated by oxidation of 5-methylcytosine, a reaction mediated by the Tet family of enzymes. Its molecular formula is C5H7N3O2.

基本信息

中文名称

2-羟基-4-氨基-5-羟甲基嘧啶

英文名称

5-(hydroxymethyl)cytosine

中文别名

4-氨基-5-(羟甲基)嘧啶-2-醇、2-羟基-4-氨基-5-甲基吡啶、4-氨基-2-羟基-5-羟甲基嘧啶、2-羟基-6=氨基-5-羟甲基嘧啶、5-羟甲基胞嘧啶、5-羟甲基胞间二氮苯

英文别名

6-amino-5-(hydroxymethyl)-1H-pyrimidin-2-one、4-AMINO-2-HYDROXY-5-(HYDROXYMETHYL)PYRIMIDINE、5-Hydroxymethylcytosine、2(1H)-Pyrimidinone, 4-amino-5-(hydroxymethyl)-

CAS号

1123-95-1

分子式

C5H7N3O2

分子量

141.128

精确质量

141.054

PSA

92.26

LOGP

-0.1621