百科

1-(2'-C-methyl-β-D-arabinofuranosyl)uracil

1-(2'-C-methyl-β-D-arabinofuranosyl)uracil

CAS号：114262-49-6

英文名：1-(2'-C-methyl-β-D-arabinofuranosyl)uracil

分子式

C10H14N2O6

熔点

密度

分子量

258.228

沸点

溶解度

信号词

危险品标志

若想填写更详细的询价信息，请点击进入询价页面

点我

化合物简介

1-β-D-Arabinofuranosyluracil-2-C-methyl is an impurity of PSI-7977, a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

基本信息

中文名称

1-(2'-C-methyl-β-D-arabinofuranosyl)uracil

英文名称

1-(2'-C-methyl-β-D-arabinofuranosyl)uracil

中文别名

英文别名

.2\'-C-methyl- arabino-uridine、2\'-methyl-1-β-D-arabinofuranosyluracil、Sofosbuvir Impurity 12

CAS号

114262-49-6

分子式

C10H14N2O6

分子量

258.228

精确质量

258.085

PSA

124.78

LOGP

-2.4618

合成路线

((2R,3R,3aS,9aR)-3-(benzoyloxy)-3a-methyl-6-oxo-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-2-yl)methyl benzoate

((2R,3R,3aS,9aR)-3-(benzoyloxy)-3a-methyl-6-oxo-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-2-yl)methyl benzoate

2’-C-甲基尿苷

2’-C-甲基尿苷

1-(2'-C-methyl-β-D-arabinofuranosyl)uracil

1-(2'-C-methyl-β-D-arabinofuranosyl)uracil

上游原料

共找到6个上游原料 >

4-ethoxy-1-(3,5-O-TIPDS-1,3-diyl-β-D-ribofuranosyl)-2(1H)-pyrimidinone

4-ethoxy-1-(3,5-O-TIPDS-1,3-diyl-β-D-ribofuranosyl)-2(1H)-pyrimidinone

4-chloro-1-(tri-O-acetyl-β-D-ribofuranosyl)-1H-pyrimidin-2-one

4-chloro-1-(tri-O-acetyl-β-D-ribofuranosyl)-1H-pyrimidin-2-one

4-ethoxy-1-(β-D-ribofuranosyl)-2(1H)-pyrimidinone

4-ethoxy-1-(β-D-ribofuranosyl)-2(1H)-pyrimidinone

4-ethoxy-1-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-erythro-2-pentulofuranosyl]-2(1H)-pyrimidinone

4-ethoxy-1-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-erythro-2-pentulofuranosyl]-2(1H)-pyrimidinone

尿嘧啶核苷

尿嘧啶核苷

((2R,3R,3aS,9aR)-3-(benzoyloxy)-3a-methyl-6-oxo-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-2-yl)methyl benzoate

((2R,3R,3aS,9aR)-3-(benzoyloxy)-3a-methyl-6-oxo-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-2-yl)methyl benzoate

上游原料

4-ethoxy-1-(3,5-O-TIPDS-1,3-diyl-β-D-ribofuranosyl)-2(1H)-pyrimidinone 4-chloro-1-(tri-O-acetyl-β-D-ribofuranosyl)-1H-pyrimidin-2-one 4-ethoxy-1-(β-D-ribofuranosyl)-2(1H)-pyrimidinone 4-ethoxy-1-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-erythro-2-pentulofuranosyl]-2(1H)-pyrimidinone 尿嘧啶核苷 ((2R,3R,3aS,9aR)-3-(benzoyloxy)-3a-methyl-6-oxo-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-2-yl)methyl benzoate