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他比特啶

他比特啶

CAS号：114899-77-3

英文名：trabectedin

分子式

C39H43N3O11S

熔点

密度

1.53g/cm3

分子量

761.837

沸点

溶解度

信号词

危险品标志

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化合物简介

A tetrahydroisoquinoline alkaloid with antitumor activity isolated from the Caribbean tunicate, Ecteinascidin turbinata. It is the first marine anticancer agent approved in the European Union for patients with soft tissue sarcoma (STS). Antineoplastic.

基本信息

中文名称

他比特啶

英文名称

trabectedin

中文别名

他比特定

英文别名

Yondelis(R)、5-(acetyloxy)-3\',4\',6,6a,7,13,14,16-octahydro-6\',8,14-trihydroxy-7\',9-dimethoxy-4,10,23-trimethyl-,[6R-(6a,6a3,73,133,143,16a,20R*)]、Ecteinascidin、ET-743、Yondelis、Ecteinascidine 743、ecteinascidin-743、Trabectedin、(1\'R,6R,6aR,7R,13S,14S,16R)

CAS号

114899-77-3

分子式

C39H43N3O11S

分子量

761.837

精确质量

761.262

PSA

194.02

LOGP

3.6178

编号系统

UNII

ID0YZQ2TCP

物化性质

密度

1.53g/cm3

折射率

1.723

合成路线

ecteinascidin 770

ecteinascidin 770

他比特啶

上游原料

共找到138个上游原料 >

4-methoxy-3-(methoxymethoxy)-5-methylbenzaldehyde

4-methoxy-3-(methoxymethoxy)-5-methylbenzaldehyde

(2R)-2-((2S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)-N-(1-((4-methoxyphenyl)amino)-1-oxopropan-2-yl)propanamido)-2-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl acetate

(2R)-2-((2S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)-N-(1-((4-methoxyphenyl)amino)-1-oxopropan-2-yl)propanamido)-2-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl acetate

3-(benzyloxy)-2-iodo-4-methoxy-5-methylbenzaldehyde

3-(benzyloxy)-2-iodo-4-methoxy-5-methylbenzaldehyde

ecteinascidin 770

ecteinascidin 770

7-((R)-2-hydroxy-1-(((R)-2-hydroxy-2-methyl-1-phenylpropyl)amino)ethyl)-5-(methoxymethoxy)benzo[d][1,3]dioxol-4-yl trifluoromethanesulfonate

7-((R)-2-hydroxy-1-(((R)-2-hydroxy-2-methyl-1-phenylpropyl)amino)ethyl)-5-(methoxymethoxy)benzo[d][1,3]dioxol-4-yl trifluoromethanesulfonate

(3R,5R)-3-(7-hydroxy-6-(methoxymethoxy)benzo[d][1,3]dioxol-4-yl)-6,6-dimethyl-5-phenylmorpholin-2-one

(3R,5R)-3-(7-hydroxy-6-(methoxymethoxy)benzo[d][1,3]dioxol-4-yl)-6,6-dimethyl-5-phenylmorpholin-2-one

上游原料

4-methoxy-3-(methoxymethoxy)-5-methylbenzaldehyde (2R)-2-((2S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)-N-(1-((4-methoxyphenyl)amino)-1-oxopropan-2-yl)propanamido)-2-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl acetate 3-(benzyloxy)-2-iodo-4-methoxy-5-methylbenzaldehyde ecteinascidin 770 7-((R)-2-hydroxy-1-(((R)-2-hydroxy-2-methyl-1-phenylpropyl)amino)ethyl)-5-(methoxymethoxy)benzo[d][1,3]dioxol-4-yl trifluoromethanesulfonate (3R,5R)-3-(7-hydroxy-6-(methoxymethoxy)benzo[d][1,3]dioxol-4-yl)-6,6-dimethyl-5-phenylmorpholin-2-one 7-((R)-2-((tert-butyldiphenylsilyl)oxy)-1-(((R)-2-hydroxy-2-methyl-1-phenylpropyl)amino)ethyl)-5-(methoxymethoxy)benzo[d][1,3]dioxol-4-yl trifluoromethanesulfonate 5-(methoxymethoxy)-4-methyl-1,3-benzodioxole tert-butyl ((2S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl)-1-(((R)-2-((tert-butyldiphenylsilyl)oxy)-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl)(1-((4-methoxyphenyl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)carbamate 3-hydroxy-2-iodo-4-methoxy-5-methylbenzaldehyde 6-Hydroxy-7-methyl-1,3-benzodioxole-5-carbaldehyde methyl (S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)propanoate tert-butyl (2S)-4-((R)-2-acetoxy-1-(7-methyl-6-((methylsulfonyl)oxy)benzo[d][1,3]dioxol-4-yl)ethyl)-2-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylbenzyl)-5-methyl-3,6-dioxopiperazine-1-carboxylate tert-butyl (S)-4-((R)-2-acetoxy-1-(7-methyl-6-((methylsulfonyl)oxy)benzo[d][1,3]dioxol-4-yl)ethyl)-2-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylbenzyl)-5-methyl-3-oxo-3,4-dihydropyrazine-1(2H)-carboxylate Toluene-4-sulfonic acid 5-bromo-2-hydroxy-3-methyl-phenyl ester 2,2,2-trichloroethyl (1R,2R,5S)-10-(benzyloxy)-2-(((tert-butyldimethylsilyl)oxy)methyl)-3-((R)-2-hydroxy-1-(6-hydroxy-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl)-9-methoxy-8-methyl-4-oxo-1,2,3,4,5,6-hexahydro-1,5-epiminobenzo[d]azocine-11-carboxylate (3R,5R,6R,12S,12aS)-2,2,2-trichloroethyl 7-(benzyloxy)-3-[6-(benzyloxy)-7-methylbenzo[d][1,3]dioxol-4-yl]-5-{[(tert-butyldimethylsilyl)oxy]methyl}-8-methoxy-9-methyl-3,5,6,11,12,12a-hexahydro-2H-6,12-epiminobenzo[e]oxazolo[3,2-a]azocine-13-carboxylate alcohol compound tert-butyl ((S)-1-((((6S,7R,9R,14aS,15R)-7-cyano-2,11-dimethoxy-1-(methoxymethoxy)-3,12,16-trimethyl-10,13-dioxo-6,7,9,10,13,14,14a,15-octahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinolin-9-yl)methyl)amino)-1-oxopropan-2-yl)carbamate 2,2,2-trichloroethyl (1R,5S)-3-((R)-2-acetoxy-1-(6-acetoxy-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl)-10-(benzyloxy)-9-methoxy-8-methyl-2-methylene-4-oxo-1,2,3,4,5,6-hexahydro-1,5-epiminobenzo[d]azocine-11-carboxylate 5-(methoxymethoxy)-1,3-benzodioxole nitrile compound 5-bromo-2-methoxy-1-(methoxymethoxy)-3-methylbenzene 2-benzyloxy-3-methyl-4,5-methylenedioxybenzaldehyde (2R)-2-((3S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylbenzyl)-6-methyl-2,5-dioxopiperazin-1-yl)-2-(7-methyl-6-((methylsulfonyl)oxy)benzo[d][1,3]dioxol-4-yl)ethyl acetate (R)-2-((tert-butyldiphenylsilyl)oxy)-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethan-1-amine (R)-1-(((R)-2-((tert-butyldiphenylsilyl)oxy)-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl)amino)-2-methyl-1-phenylpropan-2-ol tert-butyl ((2S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl)-1-(((R)-2-hydroxy-1-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl)(1-((4-methoxyphenyl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)carbamate 5-bromo-2-methoxy-3-methylphenol Trifluoro-methanesulfonic acid 7-((3R,5R)-6,6-dimethyl-2-oxo-5-phenyl-morpholin-3-yl)-5-methoxymethoxy-benzo[1,3]dioxol-4-yl ester (S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid methyl (Z)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylphenyl)-2-((tert-butoxycarbonyl)amino)acrylate 5-(dimethoxymethyl)-2-methoxy-1-(methoxymethoxy)-3-methylbenzene 6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxole-5-carbaldehyde 2,2,2-trichloroethyl (1R,2R,5S)-10-(benzyloxy)-3-((R)-1-(6-(benzyloxy)-7-methylbenzo[d][1,3]dioxol-4-yl)-2-hydroxyethyl)-2-(((tert-butyldimethylsilyl)oxy)methyl)-9-methoxy-8-methyl-4-oxo-1,2,3,4,5,6-hexahydro-1,5-epiminobenzo[d]azocine-11-carboxylate 芝麻酚 tert-butyl ((S)-1-((((6S,7R,9R,14aS,15R)-7-cyano-1-hydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,7,9,10,13,14,14a,15-octahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinolin-9-yl)methyl)amino)-1-oxopropan-2-yl)carbamate 1-allyl 3-(2,2-dimethoxyethyl) 2-((6-(benzyloxy)-7-methylbenzo[d][1,3]dioxol-5-yl)methylene)malonate 5-bromo-2-methoxy-3-methylphenyl 4-methylbenzenesulfonate silanylether (2R)-2-((3S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylbenzyl)-6-methyl-2,5-dioxopiperazin-1-yl)-2-(6-hydroxy-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl acetate 2-hydroxy-3-methylphenyl 4-methylbenzenesulfonate tert-butyl (1R,5S)-3-((R)-2-acetoxy-1-(6-acetoxy-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl)-10-(benzyloxy)-9-methoxy-8-methyl-2-methylene-4-oxo-1,2,3,4,5,6-hexahydro-1,5-epiminobenzo[d]azocine-11-carboxylate 5-(methoxymethoxy)-1,3-benzodioxol-4-ol (2R)-2-((3S)-3-(3-(benzyloxy)-2-iodo-4-methoxy-5-methylbenzyl)-6-methyl-2,5-dioxopiperazin-1-yl)-2-(6-hydroxy-7-methylbenzo[d][1,3]dioxol-4-yl)ethyl acetate tert-butyl ((S)-1-((((6S,7R,9R,14aS,15R)-7-cyano-11-hydroxy-2-methoxy-1-(methoxymethoxy)-3,12,16-trimethyl-10,13-dioxo-6,7,9,10,13,14,14a,15-octahydro-5H-6,15-epiminobenzo[4,5]azocino[1,2-b]isoquinolin-9-yl)methyl)amino)-1-oxopropan-2-yl)carbamate