化合物简介
Epipregnanolone, also known as 3β-Hydoxy-5β-pregnan-20-one or 3β,5β-tetrahydroprogesterone (3β,5β-THP), is an endogenous neurosteroid. It acts as a negative allosteric modulator of the GABAA receptor and reverses the effects of potentiators like allopregnanolone. Epipregnanolone is biosynthesized from progesterone by the actions of 5β-reductase and 3β-hydroxysteroid dehydrogenase, with 5β-dihydroprogesterone as the intermediate in this two-step transformation.
基本信息
中文名称
3Beta-羟基-5-beta-妊娠-20-酮
英文名称
3β-hydroxy-5β-pregnan-20-one
中文别名
英文别名
3.β.-Hydroxy-5.β.-tetrahydroprogesterone、5B-pregnan-3B-ol-20-one crystalline、3alpha-hydroxy-5beta-pregnan-20-one、3beta-hydroxy-5beta-pregnan-20-one、Pregnan-20-one, 3-hydroxy-, (3β,5β)-
CAS号
128-21-2
分子式
C21H34O2
分子量
318.493
精确质量
318.256
PSA
37.3
LOGP
4.5952
编号系统
UNII
3KQ00893OL
物化性质
密度
1.053 g/cm3
沸点
431.2ºC at 760 mmHg
闪点
183.9ºC
折射率
1.524
蒸汽压
3.05E-09mmHg at 25°C
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