百科

Dexelvucitabine

Dexelvucitabine

CAS号：134379-77-4

英文名：4-amino-5-fluoro-1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidin-2-one

分子式

C9H10FN3O3

熔点

密度

1.66g/cm3

分子量

227.192

沸点

394.9ºC at 760mmHg

溶解度

信号词

危险品标志

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化合物简介

Dexelvucitabine is a failed experimental agent for the management of HIV infection. Dexelvucitabine is a cytidine nucleoside analog and nucleoside reverse transcriptase inhibitor. It was found to inhibit HIV-1 replication in vitro and during Phase II clinical trials, it was found to decrease mean viral load in patients with HIV.[medical citation needed]; On April 3, 2006, Pharmasset and Incyte, the pharmaceutical companies developing dexelvucitabine announced the decision to cease further trials and development of the drug due to an increased incidence of grade 4 hyperlipasemia (an excess of the pancreatic enzyme, lipase) in a phase II trial.

基本信息

中文名称

Dexelvucitabine

英文名称

4-amino-5-fluoro-1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidin-2-one

中文别名

英文别名

Reverset、Dexelvucitabine、DFC、YZ-817、2\',3\'-didehydro-2,3-dideoxy-5-fluorocytidine、D-D4FC、INCB-8721、DPC-817

CAS号

134379-77-4

分子式

C9H10FN3O3

分子量

227.192

精确质量

227.071

PSA

90.37

LOGP

-0.0083

编号系统

UNII

KU8SPJ271W

物化性质

密度

1.66g/cm3

沸点

394.9ºC at 760mmHg

闪点

192.6ºC

折射率

1.665

蒸汽压

7.15E-08mmHg at 25°C

合成路线

共找到1条合成路线 >

β-D-5'-O-(tert-butyldiphenylsilyl)-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine

β-D-5'-O-(tert-butyldiphenylsilyl)-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine

Dexelvucitabine

Dexelvucitabine

上游原料

共找到11个上游原料 >

1,2-O-异亚丙基-alpha-D-呋喃木糖

1,2-O-异亚丙基-alpha-D-呋喃木糖

1,2-O-isopropylidene-3,5-di-O-p-methoxybenzoyl-α-D-xylofuranose

1,2-O-isopropylidene-3,5-di-O-p-methoxybenzoyl-α-D-xylofuranose

β-D-5'-O-(tert-butyldiphenylsilyl)-2',3'-dideoxy-5-fluoro-2'-(phenylselenenyl)cytidine

β-D-5'-O-(tert-butyldiphenylsilyl)-2',3'-dideoxy-5-fluoro-2'-(phenylselenenyl)cytidine

D-threo-Pent-1-enitol, 1,4-anhydro-2-deoxy-, dibenzoate

D-threo-Pent-1-enitol, 1,4-anhydro-2-deoxy-, dibenzoate

4-methoxybenzoic acid 5-(4-amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydrofuran-2-ylmethyl ester

4-methoxybenzoic acid 5-(4-amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydrofuran-2-ylmethyl ester

1,2-O-isopropylidene-3,5-di-O-benzoyl-α-D-xylofuranose

1,2-O-isopropylidene-3,5-di-O-benzoyl-α-D-xylofuranose

下游产品

共找到2个下游商品 >

氟胞嘧啶

上游原料

1,2-O-异亚丙基-alpha-D-呋喃木糖 1,2-O-isopropylidene-3,5-di-O-p-methoxybenzoyl-α-D-xylofuranose β-D-5'-O-(tert-butyldiphenylsilyl)-2',3'-dideoxy-5-fluoro-2'-(phenylselenenyl)cytidine 4-methoxybenzoic acid 5-(4-amino-5-fluoro-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydrofuran-2-ylmethyl ester 1,2-O-isopropylidene-3,5-di-O-benzoyl-α-D-xylofuranose 1,4-anhydro-3',5'-di-p-methoxybenzoyloxy-2-deoxy-D-threo-pent-1-enitol β-D-5'-O-(tert-butyldiphenylsilyl)-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine (2R,3S,4R,5R)-5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-iodotetrahydrofuran-3-yl benzoate

下游产品

糠醇氟胞嘧啶