化合物简介
Dexelvucitabine is a failed experimental agent for the management of HIV infection. Dexelvucitabine is a cytidine nucleoside analog and nucleoside reverse transcriptase inhibitor. It was found to inhibit HIV-1 replication in vitro and during Phase II clinical trials, it was found to decrease mean viral load in patients with HIV.[medical citation needed]; On April 3, 2006, Pharmasset and Incyte, the pharmaceutical companies developing dexelvucitabine announced the decision to cease further trials and development of the drug due to an increased incidence of grade 4 hyperlipasemia (an excess of the pancreatic enzyme, lipase) in a phase II trial.
基本信息
中文名称
Dexelvucitabine
英文名称
4-amino-5-fluoro-1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidin-2-one
中文别名
英文别名
Reverset、Dexelvucitabine、DFC、YZ-817、2\',3\'-didehydro-2,3-dideoxy-5-fluorocytidine、D-D4FC、INCB-8721、DPC-817
CAS号
134379-77-4
分子式
C9H10FN3O3
分子量
227.192
精确质量
227.071
PSA
90.37
LOGP
-0.0083
编号系统
UNII
KU8SPJ271W
物化性质
密度
1.66g/cm3
沸点
394.9ºC at 760mmHg
闪点
192.6ºC
折射率
1.665
蒸汽压
7.15E-08mmHg at 25°C
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