百科

阿戈美拉汀

阿戈美拉汀

CAS号：138112-76-2

英文名：Agomelatine

分子式

C15H17NO2

熔点

107-109ºC

密度

1.109g/cm3

分子量

243.301

沸点

478.8ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Agomelatine is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C receptors, respectively.

基本信息

中文名称

阿戈美拉汀

英文名称

Agomelatine

中文别名

N-[2-(7-甲氧基-1-萘基)乙基]乙酰胺、阿戈美拉汀(I型)、N-[2-(7-甲氧基-1-萘基)乙基] 乙酰胺、N-[2-(7-甲氧基萘-1-基)乙基]乙酰胺

英文别名

N-[2-(7-Methoxy-1-naphthalenyl)ethyl]-acetamide S-20098、Unii-137R1N49ad、N-[2-(7-Methoxy-1-naphthalenyl)ethyl]acetamide、AGOMELATINE、Valdoxan、AGOMELATIN、N-(2-(7-Methoxynaphthalen-1-yl)ethyl)acetamide

CAS号

138112-76-2

分子式

C15H17NO2

分子量

243.301

精确质量

243.126

PSA

38.33

LOGP

2.9179

编号系统

MDL号

MFCD00916659

物化性质

外观与性状

白色固体

密度

1.109g/cm3

沸点

478.8ºC at 760 mmHg

熔点

107-109ºC

闪点

243.4ºC

安全信息

海关编码

2924199090

生产方法及用途

用途

一种新型的抗抑郁药，为褪黑激素受体激动剂和5-羟色胺(5-HT)2C受体拮抗剂。

合成路线

共找到2条合成路线 >

乙酸酐

7-甲氧基-1-萘基乙腈

7-甲氧基-1-萘基乙腈

阿戈美拉汀

阿戈美拉汀

上游原料

共找到58个上游原料 >

2-(7-methoxy-3,4-dihydro-naphthalene-1-yl)-ethylamine hydrochloride

2-(7-methoxy-3,4-dihydro-naphthalene-1-yl)-ethylamine hydrochloride

2-(7-methoxynaphthalen-1-yl)acetyl chloride

2-(7-methoxynaphthalen-1-yl)acetyl chloride

2-(2-methoxynaphthalen-8-yl)acetaldehyde oxime

2-(2-methoxynaphthalen-8-yl)acetaldehyde oxime

N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide oxalate

N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide oxalate

1-碘-7-甲氧基萘

1-碘-7-甲氧基萘

1-氨基-7-萘酚

1-氨基-7-萘酚

下游产品

共找到2个下游商品 >

N-(2-(7-羟基萘-1-基)乙基)乙酰胺

N-(2-(7-羟基萘-1-基)乙基)乙酰胺

N-[2-(3-bromo-7-methoxynaphthalen-1-yl)ethyl]acetamide

N-[2-(3-bromo-7-methoxynaphthalen-1-yl)ethyl]acetamide

上游原料

2-(7-methoxy-3,4-dihydro-naphthalene-1-yl)-ethylamine hydrochloride 2-(7-methoxynaphthalen-1-yl)acetyl chloride 2-(2-methoxynaphthalen-8-yl)acetaldehyde oxime N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide oxalate 1-碘-7-甲氧基萘 1-氨基-7-萘酚 7-甲氧基-1-萘基乙酸乙酯 (7-methoxy-1,2-dihydro-1-naphthyl)acetonitrile N-(2-(7-羟基萘-1-基)乙基)乙酰胺 1-(2-aminoethyl)-7-methoxy-1,2,3,4-tetrahydronaphthalene 7-甲氧基-1-萘乙酰胺乙酰氯 1-(2-chloroethyl)-7-methoxynaphthalene 乙酸酐 2-(7-methoxy-3,4-dihydro-1-naphthyl)ethylamine N-[2-(1-hydroxyl-7-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)ethyl]-acetamide 8-(2-chloroethyl)naphthalen-2-yl acetate 1-(2-chloroethyl)-7-hydroxynaphthalene 7-甲氧基-1-萘并ni三le 7-甲氧基-1-萘满酮 7-甲氧基-1-萘乙醇 N-[2-(7-methoxy-3,4-dihydro-naphthalen-1-yl)ethyl]acetamide 7-甲氧基-1-萘乙酸 7-羟基-3,4-二氢-2H-1-萘酮 (E)-1-[2-(acetylamino)ethylidene]-7-methoxy-1,2,3,4tetrahydronaphthalene (7-methoxy-3,4-dihydro-2H-naphthalene-1-ylidene)acetonitrile 7-甲氧基-1-萘基乙腈 2-(1-hydroxyl-7-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetonitrile 2-(7-methoxynaphthalene-1-yl)ethylmethanesulfonate 7-甲氧基-3,4-二氢-1-萘基乙腈 8-碘-2-萘酚 N-formyl-N-(2-(7-methoxynaphthalen-1-yl)ethyl)formamide 7-甲氧基-1-萘乙胺 ethyl (1,2,3,4-tetrahydro-7-methoxy-1-naphthyl)acetate N-[2-(4-bromo-7-methoxy-1,2-dihydro-1-naphthyl)ethyl]acetamide 7-methoxy-1-naphthylethyl benzenesulfonate 乙酸-2-萘酯 2-(7-甲氧基萘-1-基)乙胺盐酸盐 2-萘酚 7-甲氧基萘-1-羧醛 1-(2-nitroethyl)-7-methoxynaphthalene 7-methoxy-1-(N-phthalimidoethyl)naphthalene O-Ethyl S-[2-(4-methoxyphenyl)-2-oxoethyl] carbonodithioate

下游产品

N-(2-(7-羟基萘-1-基)乙基)乙酰胺 N-[2-(3-bromo-7-methoxynaphthalen-1-yl)ethyl]acetamide