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埃博霉素B

埃博霉素B

CAS号:152044-54-7
英文名:epothilone B
分子式:C27H41NO6S
分子量:507.683
上游原料
(2E)-2-Methyl-3-(2-methyl-1,3-thiazol-4-yl)acrylaldehyde (2S,3S,4R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-[1,3]dithian-2-yl-2,4,6-trimethyl-5-triphenylsilanyloxy-heptan-1-ol Epothilone D 2,2-Dimethyl-3-oxopentanal (4S,7R,8S,9S,13Z,16S)-4,8-二-{[叔-丁基(二甲基)硅烷基]氧基}-5,5,7,9,13-五甲基-16-[(E)-1-甲基-2-(2-甲基-1,3-噻唑-4-基)乙烯基]氧代环己癸-13-烯-2,6-二酮 (1S,3S,7S,10R,11S,12S,16R)-7-((tert-butyldimethylsilyl)oxy)-11-hydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione (3R,4R,5S)-3-(2-(1,3-dithian-2-yl)propan-2-yl)-5-((S)-1-(benzyloxy)propan-2-yl)-4,7,7,8,8-pentamethyl-1,1,1-triphenyl-2,6-dioxa-1,7-disilanonane (3R,4R,5S,6S)-6-((S)-1-(benzyloxy)propan-2-yl)-3-(iodomethyl)-2-methoxy-3,5-dimethyltetrahydro-2H-pyran-4-ol (E)-9,10-dehydroepothilone B (3S)-4-[7-bromo-3-(tert-butyl-dimethyl-silanyloxy)-2,6-dimethyl-hepta-1,5-dienyl]-2-methyl-thiazole (1S)-[(1E)-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethynyl]-3-butenyl acetate 2-甲基-1,3-噻唑-4-甲醛 (3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-9-(4-methoxy-benzyloxy)-4,4,6,8-tetramethyl-5-oxo-nonanoic acid (3S,6R,7S,8S,12Z,15S,16E)-5-oxo-15-hydroxy-3-triethylsilanoxy-17-(2-methylthiazol-4-yl)-4,4,6,8,12,16-hexamethyl-7-(2,2,2-trichloroethoxycarbonyloxy)heptadeca-12,16-dienoic acid (1R,3S,4S,5R,6R)-3-((S)-2-Benzyloxy-1-methyl-ethyl)-4,6-dimethyl-2-oxa-bicyclo[4.1.0]heptan-5-ol (1E,3Z)-1-甲氧基-2-甲基-3-(三甲基硅氧基)-1,3-戊二烯 tert-butyl 4,4-dimethyl-3,5-dioxoheptanoate (3S,6R,7S,8S,12Z,15S,16E)-1,3,7,15-四-{[叔-丁基(二甲基)硅烷基]氧基}-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七-12,16-二烯-5-酮 (4R,5S,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methoxy-3,3,5-trimethyl-tetrahydro-pyran-4-ol tert-butyl (6R,7S,8S,12Z,15S,16E)-3,5-dioxo-15-hydroxy-17-(2-methylthiazol-4-yl)-4,4,6,8,12,16-hexamethyl-(2,2,2-trichloroethoxycarbonyl)pentadeca-12,16-dieno-ate (2S,3S,4R,5R)-1-(benzyloxy)-6-(1,3-dithian-2-yl)-2,4,6-trimethyl-5-((triphenylsilyl)oxy)heptan-3-ol (3S,6R,7S,8S,12Z,15S,16E)-3,7,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-1-羟基-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七-12,16-二烯-5-酮 (5S)-5-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethyloct-7en-3-one S-ethyl (2S,Z)-2-((tert-butyldimethylsilyl)oxy)-5-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)hex-4-enethioate (3S,6R,7S,12Z,15S,16E)-3,7-二-{[叔-丁基(二甲基)硅烷基]氧基}-15-羟基-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)-5-氧代十七碳-12,16-二烯酸 (4S)-4-benzyl-3-((Z)-5-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)hex-4-enoyl)oxazolidin-2-one (S)-4-Benzyl-3-[(Z)-(S)-2-(tert-butyl-dimethyl-silanyloxy)-5-methyl-6-(tetrahydro-pyran-2-yloxy)-hex-4-enoyl]-oxazolidin-2-one (3S,6R,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-9-hydroxy-4,4,6,8-tetramethyl-5-oxo-nonanoic acid methyl ester methyl (3S,6R,7S,8R)-3,7-bis((tert-butyldimethylsilyl)oxy)-4,4,6,8-tetramethyl-5,9-dioxononanoate (3S)-2-methyl-1-(2-methyl-1,3-thiazol-4-yl)hexa-1,5-dien-3-ol (3S,6R,7S,8S,12Z,15S,16E)-1,3,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-7-羟基-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七烷基-12,16-二烯-5-酮 (-)-(2Z,5S,6E)-5-{[叔-丁基(二甲基)硅烷基]氧基}-2,6-二甲基-7-(2-甲基-1,3-噻唑-4-基)庚-2,6-二烯-1-醇 (Z)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-7-(tetrahydro-pyran-2-yloxy)-hept-5-en-2-one (3S,6R,7S,8S)-3,7-bis((tert-butyldimethylsilyl)oxy)-9-((4-methoxybenzyl)oxy)-4,4,6,8-tetramethyl-5-oxononanal 12,13-deoxy-7-(2,2,2-trichloroethoxycarbonyl)-3-(triethylsilyloxy)epothilone B (5S)-5,7-二-{[叔-丁基二甲基硅烷基)氧基]}-4,4-二甲基庚烷-3-酮 (2R,3R,4R,5R)-3-((tert-butyldimethylsilyl)oxy)-6-(1,3-dithian-2-yl)-2,4,6-trimethyl-5-((triphenylsilyl)oxy)heptanal (2S,3S,4R,7S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-2,4,6,6-tetramethyl-dec-9-en-5-one (2S,3S,4R)-2-((S)-1-(benzyloxy)propan-2-yl)-3,5-dimethyl-3,4-dihydro-2H-pyran-4-ol (2S,3S,4R,7S)-7-((tert-butyldimethylsilyl)oxy)-3-hydroxy-1-((4-methoxybenzyl)oxy)-2,4,6,6-tetramethyldec-9-en-5-one tert-butyl (3S,6R,7S,8S,12Z,15S,16E)-5-oxo-3,15-dihydroxy-17-(2-methylthiazol-4-yl)-4,4,6,8,12,16-hexamethyl-(2,2,2-trichloroethoxycarbonyl)pentadeca-12,16-dienoate 4-((1E,3S,5Z)-3-((tert-butyldimethylsilyl)oxy)-2,6-dimethyl-7-((tetrahydro-2H-pyran-2-yl)oxy)hepta-1,5-dien-1-yl)-2-methylthiazole [(4R,5R,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methoxy-3,3,5-trimethyl-tetrahydro-pyran-4-yloxy]-triphenyl-silane tert-Butyldimethylsilyl {(1S,3Z)-4-iodo-1-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-3-pentenyl} ether tert-butyl (6R,7S,8S,12Z,15S,16E)-15-((tert-butyldimethylsilyl)oxy)-4,4,6,8,12,16-hexamethyl-17-(2-methylthiazol-4-yl)-3,5-dioxo-7-(((2,2,2-trichloroethoxy)carbonyl)oxy)heptadeca-12,16-dienoate (3S,4E)-3-{[tert-butyl(dimethyl)silyl]oxy}-4-methyl-5-(2-methyl-1,3-thiazol-4-yl)pent-4-en-1-al