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利克飞龙

利克飞龙

CAS号：156897-06-2

英文名：Licofelone

分子式

C23H22ClNO2

熔点

162-163ºC

密度

1.23

分子量

379.879

沸点

539.7ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Licofelone is a dual COX/LOX inhibitor being considered as a treatment for osteoarthritis and which is under development by Merckle GmbH with partners Alfa Wassermann and Lacer.

基本信息

中文名称

利克飞龙

英文名称

Licofelone

中文别名

2-[2-(4-氯苯基)-6,6-二甲基-1-苯基-5,7-二氢吡咯烷嗪-3-基]乙酸

英文别名

[2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid、2-[2-(4-Chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid、ML-3000

CAS号

156897-06-2

分子式

C23H22ClNO2

分子量

379.879

精确质量

379.134

PSA

42.23

LOGP

5.6849

编号系统

UNII

P5T6BYS22Y

物化性质

外观与性状

淡黄色固体

密度

1.23

沸点

539.7ºC at 760 mmHg

熔点

162-163ºC

闪点

280.2ºC

折射率

1.626

蒸汽压

1.76E-12mmHg at 25°C

合成路线

156897-35-7

利克飞龙

上游原料

共找到21个上游原料 >

2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetamide

2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetamide

5-苄基-3,4-二氢-3,3-二甲基-2H-吡咯

5-苄基-3,4-二氢-3,3-二甲基-2H-吡咯

methyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetate

methyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetate

ethyl 2-(2,2-dimethyl-7-phenyl-6-trifluoromethanesulfonyloxy-2,3-dihydro-1H-pyrrolizin-5-yl)-2-oxoacetate

ethyl 2-(2,2-dimethyl-7-phenyl-6-trifluoromethanesulfonyloxy-2,3-dihydro-1H-pyrrolizin-5-yl)-2-oxoacetate

4,4-二甲基-1,3,2-二氧硫杂环己烷2-氧化物

4,4-二甲基-1,3,2-二氧硫杂环己烷2-氧化物

[6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizin-5-yl]acetic acid tert-butyl ester

[6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizin-5-yl]acetic acid tert-butyl ester

上游原料

2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetamide 5-苄基-3,4-二氢-3,3-二甲基-2H-吡咯 methyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetate ethyl 2-(2,2-dimethyl-7-phenyl-6-trifluoromethanesulfonyloxy-2,3-dihydro-1H-pyrrolizin-5-yl)-2-oxoacetate 4,4-二甲基-1,3,2-二氧硫杂环己烷2-氧化物 [6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizin-5-yl]acetic acid tert-butyl ester ethyl 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-oxoacetate methyl N-(2,2-dimethyl-5-phenylpent-4-ynyl)glycinate 3,3-dimethyl-4-hydroxy butyronitrile 2,2-dimethyl-7-phenyl-2,3,5,6-tetrahydro-1H-pyrrolizin-6-one ethyl 2-(2,2-dimethyl-6-hydroxy-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-oxoacetate 2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl)-2-oxoacetyl chloride 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-1,3-dihydropyrrolizine 2,2-dimethyl-5-phenylpent-4-ynal 2'-溴-4-氯苯乙酮草酰氯 2,2-二甲基-1,3-丙二醇 1-苯基-3-氯-1-丙炔 4-chloro-3,3-dimethylbutyronitrile 苄基氯