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3,9-二甲氧基-5,8,13,13alpha-四氢-6H-异喹啉并[3,2-a]异喹啉-2,10-二醇

3,9-二甲氧基-5,8,13,13alpha-四氢-6H-异喹啉并[3,2-a]异喹啉-2,10-二醇

CAS号：16562-14-4

英文名：3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol

分子式

C19H21NO4

熔点

密度

分子量

327.374

沸点

溶解度

信号词

危险品标志

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化合物简介

A tetrahydroprotoberberine agonist at dopamine D1 and antagonist at D2 receptors. It is used for preventing or treating neural diseases . The neural diseases comprise parkinsonism, schizophrenia and dyskinesia which is produced by L-DOPA or medicine to treat schizophrenia. Antipsychotics.

基本信息

中文名称

3,9-二甲氧基-5,8,13,13alpha-四氢-6H-异喹啉并[3,2-a]异喹啉-2,10-二醇

英文名称

3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol

中文别名

英文别名

l-2,10-Dihydroxy-3,9-dimethyloxytetrahydropseudoberberine、stepholidine、L-stepholidine、D,L-Stepholidine

CAS号

16562-14-4

分子式

C19H21NO4

分子量

327.374

精确质量

327.147

PSA

62.16

LOGP

2.7084

安全信息

海关编码

2933990090

合成路线

(S)-2,10-dibenzyloxy-3,9-dimethoxytetrahydroprotoberberine

(S)-2,10-dibenzyloxy-3,9-dimethoxytetrahydroprotoberberine

3,9-二甲氧基-5,8,13,13alpha-四氢-6H-异喹啉并[3,2-a]异喹啉-2,10-二醇

3,9-二甲氧基-5,8,13,13alpha-四氢-6H-异喹啉并[3,2-a]异喹啉-2,10-二醇

上游原料

共找到33个上游原料 >

14-(S)-3,9-dimethoxyl-2,10-diisopropoxy-tetrahydroprotoberberine

14-(S)-3,9-dimethoxyl-2,10-diisopropoxy-tetrahydroprotoberberine

4-苄氧基-3-甲氧基苯乙胺

4-苄氧基-3-甲氧基苯乙胺

8-hydroxy-7-phenylmethoxy-1,4-dihydroisochromen-3-one

8-hydroxy-7-phenylmethoxy-1,4-dihydroisochromen-3-one

(S)-2,10-diisopropoxy-3,9-dimethoxy-5,6,13,13a-tetrahydro-8H-isoquinolino[3,2-a]isoquinolin-8-one

(S)-2,10-diisopropoxy-3,9-dimethoxy-5,6,13,13a-tetrahydro-8H-isoquinolino[3,2-a]isoquinolin-8-one

(4-isopropoxy-3-methoxyphenyl)-N,N-dimethylmethanamine

(4-isopropoxy-3-methoxyphenyl)-N,N-dimethylmethanamine

香草醛

上游原料

14-(S)-3,9-dimethoxyl-2,10-diisopropoxy-tetrahydroprotoberberine 4-苄氧基-3-甲氧基苯乙胺 8-hydroxy-7-phenylmethoxy-1,4-dihydroisochromen-3-one (S)-2,10-diisopropoxy-3,9-dimethoxy-5,6,13,13a-tetrahydro-8H-isoquinolino[3,2-a]isoquinolin-8-one (4-isopropoxy-3-methoxyphenyl)-N,N-dimethylmethanamine 香草醛 4-苄氧基-3-甲氧基苯甲醛 (S)-N-((S)-1-(2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-5-isopropoxy-4-methoxyphenyl)-2-(2-cyano-4-isopropoxy-3-methoxyphenyl)ethyl)-2-methylpropane-2-sulfinamide 3-isopropoxy-2-methoxy-6-methylbenzonitrile (S)-1-(2,3-diethyl-4-phenethylbenzyl)-6-ethyl-7-phenethyl-1,2,3,4-tetrahydronaphthalene 4-羟基苯乙酸甲酯 (S)-3-(2-(2-hydroxyethyl)-5-isopropoxy-4-methoxyphenyl)-7-isopropoxy-8-methoxy-3,4-dihydroisoquinolin-1(2H)-one (S)-6-(2-amino-2-(2-(2-hydroxyethyl)-5-isopropoxy-4-methoxyphenyl)ethyl)-3-isopropoxy-2-methoxybenzonitrile (S)-2,10-dibenzyloxy-3,9-dimethoxytetrahydroprotoberberine (3-(benzyloxy)-6-(((S)-7-(benzyloxy)-1,2,3,4-tetrahydro-6-methoxyisoquinolin-1-yl)-methyl)-2-methoxyphenyl)methanol (S)-3-(benzyloxy)-6-((7-(benzyloxy)-6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2-methoxybenzyl acetate 3-(benzyloxy)-6-((7-(benzyloxy)-3,4-dihydro-6-methoxyisoquinolin-1-yl)methyl)-2-methoxybenzyl acetate 6-((4-(benzyloxy-3-methoxyphenethyl)carbamoyl)methyl)-3-(benzyloxy)-2-methoxybenzyl acetate 2-(2-(tert-butyldimethylsilyloxy)ethyl)-5-isopropoxy-4-methoxybenzaldehyde 3-isopropoxy-2-methoxy-6-methylbenzamide methyl 3-isopropoxy-2-methoxy-6-methylbenzoate methyl 6-(chloromethyl)-3-isopropoxy-2-methoxybenzoate 2-(3-溴-4-羟基苯基)乙酸甲酯 methyl 2-(3-bromo-4-phenylmethoxyphenyl)acetate 2-(4-isopropoxy-3-methoxyphenyl)ethanol 3-isopropoxy-2-methoxy-6-methylbenzoic acid (2-bromo-4-isopropoxy-5-methoxyphenethyloxy)(tert-butyl)dimethylsilane 2-(2-bromo-4-isopropoxy-5-methoxyphenyl)ethanol 4-异丙氧基-3-甲氧基苯甲醛 4-苄氧基-3-羟基苯乙酸反-4-苄氧基-3-甲氧基-β-硝基苯乙烯 2-(3-methoxy-4-propan-2-yloxyphenyl)acetic acid 2-(4-(benzyloxy)-2-(hydroxymethyl)-3-methoxyphenyl)-N-(4-(benzyloxy)-3-methoxyphenethyl)acetamide