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阿利吉仑

阿利吉仑

CAS号：173334-57-1

英文名：Aliskiren

分子式

C30H53N3O6

熔点

密度

1.067 g/cm3

分子量

551.758

沸点

748.4ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Aliskiren (trade names Tekturna and Rasilez) is the first in a class of drugs called direct renin inhibitors. Its is used for essential (primary) hypertension. While used for high blood pressure, other better studied medications are typically recommended due to concerns of higher side effects and less evidence of benefit.

基本信息

中文名称

阿利吉仑

英文名称

Aliskiren

中文别名

(2S,4S,5S,7S)-5-氨基-N-(2-氨基甲酰基-2-甲基丙基)-4-羟基-2-异丙基-7-[4-甲氧基-3-(3-甲氧基丙氧基)苄基]-8-甲基壬酰胺、阿利克仑

英文别名

SPP 100、(2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide、Rasilez、Tekturna、(aS,S,dS,zS)-d-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)--hydroxy-4-methoxy-3-(3-methoxypropoxy)-a,z-bis(1-methylethyl)benzeneoctanamide、(2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-methoxybenzyl)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hydrochloride

CAS号

173334-57-1

分子式

C30H53N3O6

分子量

551.758

精确质量

551.393

PSA

146.13

LOGP

5.085

编号系统

UNII

502FWN4Q32

物化性质

密度

1.067 g/cm3

沸点

748.4ºC at 760 mmHg

闪点

406.4ºC

蒸汽压

1.12E-24mmHg at 25°C

生产方法及用途

用途

抗高血压药物、肾素抑制剂。

合成路线

共找到1条合成路线 >

deltaN-苄氧羰基阿利吉仑

deltaN-苄氧羰基阿利吉仑

阿利吉仑

上游原料

共找到103个上游原料 >

2-氰基-2-甲基丙酸乙酯

2-氰基-2-甲基丙酸乙酯

4-溴-1-甲氧基-2-(3-甲氧基丙氧基)苯

4-溴-1-甲氧基-2-(3-甲氧基丙氧基)苯

(3S,5S)-3-isopropyl-5-((S)-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentanoyl)dihydrofuran-2(3H)-one

(3S,5S)-3-isopropyl-5-((S)-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentanoyl)dihydrofuran-2(3H)-one

[1S-[1R*(R*),2R*,4R*]]-[4-[[(3-氨基-2,2-二甲基-3-氧代丙基)氨基]羰基]-2-羟基-1-[2-[[4-甲氧基-3-(3-甲氧基丙氧基)苯基]甲基]-3-甲基丁基]-5-甲基己基]-氨基甲酸叔丁酯

[1S-[1R*(R*),2R*,4R*]]-[4-[[(3-氨基-2,2-二甲基-3-氧代丙基)氨基]羰基]-2-羟基-1-[2-[[4-甲氧基-3-(3-甲氧基丙氧基)苯基]甲基]-3-甲基丁基]-5-甲基己基]-氨基甲酸叔丁酯

(2S,4E)-5-氯-N,N-二甲基-2-异丙基-4-戊烯酰胺

(2S,4E)-5-氯-N,N-二甲基-2-异丙基-4-戊烯酰胺

[(1S,3S)-1-(羟甲基)-3-[[4-甲氧基-3-(3-甲氧基丙氧基)苯基]甲基]-4-甲基戊基]氨基甲酸叔丁酯

[(1S,3S)-1-(羟甲基)-3-[[4-甲氧基-3-(3-甲氧基丙氧基)苯基]甲基]-4-甲基戊基]氨基甲酸叔丁酯

下游产品

共找到1个下游商品 >

阿利吉仑半富马酸盐

阿利吉仑半富马酸盐

上游原料

2-氰基-2-甲基丙酸乙酯 4-溴-1-甲氧基-2-(3-甲氧基丙氧基)苯 (3S,5S)-3-isopropyl-5-((S)-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentanoyl)dihydrofuran-2(3H)-one [1S-[1R*(R*),2R*,4R*]]-[4-[[(3-氨基-2,2-二甲基-3-氧代丙基)氨基]羰基]-2-羟基-1-[2-[[4-甲氧基-3-(3-甲氧基丙氧基)苯基]甲基]-3-甲基丁基]-5-甲基己基]-氨基甲酸叔丁酯 (2S,4E)-5-氯-N,N-二甲基-2-异丙基-4-戊烯酰胺 [(1S,3S)-1-(羟甲基)-3-[[4-甲氧基-3-(3-甲氧基丙氧基)苯基]甲基]-4-甲基戊基]氨基甲酸叔丁酯 (1R,3S)-1-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl methanesulfonate (3S,5S)-5-[(1S,3S)-1-叠氮基-3-[[4-甲氧基-3-(3-甲氧基丙氧基)苯基]甲基]-4-苄基]二氢-3-异丙基-2(3H)-呋喃酮 1-(((S)-2-(溴甲基)-3-甲基丁氧基)甲基)苯 3N-苄氧羰基3-氨基-2,2-二甲基丙酰胺 3-(3-甲氧基丙氧基)-4-甲氧基苯甲醛 (ar)-4-甲氧基-3-(3-甲氧基丙氧基)-a-(1-甲基乙基)-苯丙酸异戊酸 deltaN-苄氧羰基阿利吉仑 2-(3-甲氧基丙氧基)-4-溴甲基-1-甲氧基苯甲醚阿利吉仑半富马酸盐 tetrahydro-4-isopropyl-5-oxofuran-2-carbonyl chloride (4R)-3-(2S)-(2-(hydroxy(4-methoxy-3-(3-methoxypropoxy)phenyl)methyl)-3-methylbutanoyl)-4-phenyloxazolidin-2-one (3S)-5-(hydroxymethyl)-3-isopropyldihydrofuran-2(3H)-one {(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxo-furanidin-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid benzyl ester tetrahydro-4-isopropyl-5-oxofuran-2-carboxylic acid (3S,5S)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-isopropyldihydrofuran-2(3H)-one 阿利克仑-8 3-羟基-4-甲氧基苯甲醛 (4R)-3-[(2S)-3-甲基-1-氧代-2-[(苄氧基)甲基]丁基]-4-苄基-2-恶唑啉酮 (2S,5R)-3,6-二乙氧基-2,5-二氢-2-[(2S)-2-[[4-甲氧基-3-(3-甲氧基丙氧基)苯基]甲基]-3-甲基丁基]-5-异丙基吡嗪 (4S)-3-[(2S)-2-(1-methylethyl)-1-oxopent-4-en-1-yl]-4-(phenylmethyl)oxazolidin-2-one (αS,γS,δS,ζS)-N-(3-氨基-2,2-二甲基-3-氧代丙基)-δ-叠氮-γ-羟基-4-甲氧基-3-(3-甲氧基丙氧基)-α, ζ-二异丙基-苯辛酰胺 [(1S,3S)-3-[[4-甲氧基-3-(3-甲氧基丙氧基)苯基]甲基]-4-甲基-1-[(2S,4S)-四氢-4-异丙基-5-氧代-2-呋喃基]戊基]-氨基甲酸叔丁酯 (3S,5S)-5-((1R,3S)-1-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyldihydrofuran-2(3H)-one (S,E)-5-chloro-2-isopropyl pent-4-enoic acid phenyl ethanamine (R)-2-[3-(3-甲氧基丙氧基)-4-甲氧基苄基]-3-甲基丁-1-醇 ethyl (2S,4S)-2-amino-4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-methylhexanoate ethyl (αS,γS)-α-{[(1,1-dimethylethoxy)carbonyl]amino}-4-methoxy-3-(3-methoxypropoxy)-γ-(1-methylethyl)benzenepentanoate 3-(3-甲氧基丙氧基)-4-甲氧基苄醇 (R)-3-((R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoyl)-4-phenyloxazolidin-2-one 4-[(2R)-2-(氯甲基)-3-甲基丁基]-1-甲氧基-2-(3-甲氧基丙氧基)苯 2-氰基-2-甲基丙酰胺 (2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzoyl)-8-methylnonanamide 4-异丙基-5-氧代四氢-2-呋喃甲酰氯 (2S)-3-methyl-2-[(phenylmethoxy)methyl]butanoic acid (4R)-3-{(2R)-2-{[4-methoxy-3-(methoxypropoxy)phenyl]methyl-3-methyl}-1-oxobutyl}-4-(phenylmethyl)oxazolidin-2-one (3S,5R)-5-((1S,3S)-1-azido-3-(4-methoxy-3-(methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyl-dihydrofuran-2(3H)-one (2S,4S)-4-Isopropyl-5-oxo-tetrahydro-furan-2-carboxylic acid benzyl ester (3S,5S)-5-((1S,3S)-1-Azido-3-(hydroxy(4-methoxy-3-(3-methoxypropoxy)phenyl)methyl)-4-methylpentyl)-3-isopropyldihydrofuran-2(3H)-one (3S,5S)-5-(hydroxymethyl)-3-isopropyldihydrofuran-2(3H)-one (S)-2-苄氧基甲基-3-甲基-1-丁醇 tert-butyl (3S,5S)-5-((1S,3S)-3-((3-amino-2,2-dimethyl-3-oxopropyl)carbamoyl)-1-hydroxy-4-methylpentyl)-3-isopropyl-2-(4-methoxy-3-(3-methoxypropoxy)phenyl)pyrrolidine-1-carboxylate

下游产品

阿利吉仑半富马酸盐