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阿曲生坦

阿曲生坦

CAS号：173937-91-2

英文名：atrasentan

分子式

C29H38N2O6

熔点

密度

1.188g/cm3

分子量

510.622

沸点

659.4ºC at 760mmHg

溶解度

信号词

危险品标志

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化合物简介

Atrasentan is an experimental drug that is being studied for the treatment of various types of cancer, including non-small cell lung cancer. It is also being investigated as a therapy for diabetic kidney disease.

基本信息

中文名称

阿曲生坦

英文名称

atrasentan

中文别名

(2R,3R,4S)-4-(1,3-苯并二氧戊环-5-基)-1-[2-(二丁基氨基)-2-氧代乙基]-2-(4-甲氧基苯基)吡咯烷-3-羧酸

英文别名

[2R,3R,4S]-2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-[[(N,N-dibutylamino)-carboxyl]methyl]pyrrolidine-3-carboxylic acid、(2R,3R,4S)-2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-(((N,N-dibutylamino)carbonyl)methyl)pyrrolidine-3-carboxylic acid、(2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid、(2R,3R,4S)-(+)-2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-1-(N,N-di(n-butyl)aminocarbonylmethyl)-pyrrolidine-3-carboxylic acid

CAS号

173937-91-2

分子式

C29H38N2O6

分子量

510.622

精确质量

510.273

PSA

88.54

LOGP

4.6319

编号系统

UNII

V6D7VK2215

物化性质

密度

1.188g/cm3

沸点

659.4ºC at 760mmHg

闪点

352.6ºC

蒸汽压

2.76E-18mmHg at 25°C

合成路线

ethyl (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)pyrrolidin-1-ium-3-carboxylate,(2S)-2-hydroxy-2-phenylacetate

ethyl (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)pyrrolidin-1-ium-3-carboxylate,(2S)-2-hydroxy-2-phenylacetate

2-溴-N,N-二丁基乙酰胺

2-溴-N,N-二丁基乙酰胺

阿曲生坦

上游原料

共找到11个上游原料 >

ethyl (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)pyrrolidin-1-ium-3-carboxylate,(2S)-2-hydroxy-2-phenylacetate

ethyl (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)pyrrolidin-1-ium-3-carboxylate,(2S)-2-hydroxy-2-phenylacetate

ethyl (2R,3R,4S)-4-(benzo[d][1,3]dioxol-5-yl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylate

ethyl (2R,3R,4S)-4-(benzo[d][1,3]dioxol-5-yl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylate

3,4-亚甲二氧-beta-硝基苯乙烯

3,4-亚甲二氧-beta-硝基苯乙烯

二正丁胺

N,N-二异丙基乙胺

N,N-二异丙基乙胺

ethyl (2R,3R,4S)-4-(benzo[d][1,3]dioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylate

ethyl (2R,3R,4S)-4-(benzo[d][1,3]dioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylate

上游原料

ethyl (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-2-(4-methoxyphenyl)pyrrolidin-1-ium-3-carboxylate,(2S)-2-hydroxy-2-phenylacetate 3,4-亚甲二氧-beta-硝基苯乙烯二正丁胺 N,N-二异丙基乙胺 ethyl (2R,3R,4S)-4-(benzo[d][1,3]dioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylate 2-溴-N,N-二丁基乙酰胺 Ethyl 2-(4-methoxybenzoyl)-3-(3,4-methylenedioxy-phenyl)-4-nitro-butanoate 3-(4-甲氧苯基)-3-氧代丙酸乙酯 ethyl (2R,3R,4S)-(+)-2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)pyrrolidine-3-carboxylate, (S)-(+) mandelate Ethyl 2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-4.5-dihydro-3H-pyrrole-3-carboxylate