化合物简介
(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is the counterpart to (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline, the latter enantiomer being a key intermediate in the preparation of Solifenacin, an antimuscarinic agent. Since (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is produced as a by-product, it has been suggested that it should be recycled in order to obtain the S enantiomer on a larger scale. (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is also used as a reagent to prepare quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives, compounds that act as muscarinic receptor antagonists.
基本信息
中文名称
(R)-1-苯基-1,2,3,4-四氢异喹啉
英文名称
(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
中文别名
(1R)-1-苯基-1,2,3,4-四氢异喹啉
英文别名
(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
CAS号
180272-45-1
分子式
C15H15N
分子量
209.286
精确质量
209.12
PSA
12.03
LOGP
3.2505
物化性质
密度
1.065 g/cm3
沸点
338.4ºC at 760 mmHg
闪点
166.9ºC
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