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(4S,7R,8S,9S,16S)-4,8-Dihydroxy-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-1-oxa-cyclohexadecen-(13E)-en-2,6-dione

(4S,7R,8S,9S,16S)-4,8-Dihydroxy-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-1-oxa-cyclohexadecen-(13E)-en-2,6-dione

CAS号：188260-10-8

英文名：(4S,7R,8S,9S,16S)-4,8-Dihydroxy-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-1-oxa-cyclohexadecen-(13E)-en-2,6-dione

分子式

C26H39NO5S

熔点

密度

分子量

477.657

沸点

溶解度

信号词

危险品标志

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基本信息

中文名称

(4S,7R,8S,9S,16S)-4,8-Dihydroxy-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-1-oxa-cyclohexadecen-(13E)-en-2,6-dione

英文名称

(4S,7R,8S,9S,16S)-4,8-Dihydroxy-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-1-oxa-cyclohexadecen-(13E)-en-2,6-dione

中文别名

英文别名

(4S,7R,8S,9S,13E,16S)-4,8-dihydroxy-5,5,7,9-tetramethyl-16-[(1E)-1-methyl-2-(2-methylthiazol-4-yl)ethenyl]oxacyclohexadec-13-ene-2,6-dione、E-epothilone C、(12E)-Epothilone C、(E)-12,13-desoxyepothilone A、trans-epothilone C、(E)-(4S,7R,8S,9S,16S)-4,8-Dihydroxy-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-oxacyclohexadec-13-ene-2,6-dione、epothilone C

CAS号

188260-10-8

分子式

C26H39NO5S

分子量

477.657

精确质量

477.255

PSA

124.96

LOGP

4.8762

合成路线

12,13-bismethylene-12,13-secoepothilone

12,13-bismethylene-12,13-secoepothilone

埃博霉素C

(4S,7R,8S,9S,16S)-4,8-Dihydroxy-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-1-oxa-cyclohexadecen-(13E)-en-2,6-dione

(4S,7R,8S,9S,16S)-4,8-Dihydroxy-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-1-oxa-cyclohexadecen-(13E)-en-2,6-dione

上游原料

共找到21个上游原料 >

(5S)-5-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethyloct-7en-3-one

(5S)-5-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethyloct-7en-3-one

(2S)-5-benzyloxy-2-methyl-1-pentanal

(2S)-5-benzyloxy-2-methyl-1-pentanal

(3S,6R,7S,8S)-11-(benzyloxy)-3,7-bis{[(tert-butyl)dimethylsilyl]oxy}-4,4,6,8-tetramethyl-5-oxoundecanoic acid methyl ester

(3S,6R,7S,8S)-11-(benzyloxy)-3,7-bis{[(tert-butyl)dimethylsilyl]oxy}-4,4,6,8-tetramethyl-5-oxoundecanoic acid methyl ester

12,13-bismethylene-12,13-secoepothilone

12,13-bismethylene-12,13-secoepothilone

(4S,7R,8S,9S,16S)-4,8-bis-(tert-butyldimethylsilanyloxy)-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-vinyl]-(13Z)-1-oxacyclohexadec-13-ene-2,6-dione

(4S,7R,8S,9S,16S)-4,8-bis-(tert-butyldimethylsilanyloxy)-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-vinyl]-(13Z)-1-oxacyclohexadec-13-ene-2,6-dione

(S)-5-((tert-butyldimethylsilyl)oxy)-4,4-dimethyl-7-((triethylsilyl)oxy)heptan-3-one

(S)-5-((tert-butyldimethylsilyl)oxy)-4,4-dimethyl-7-((triethylsilyl)oxy)heptan-3-one

上游原料

(5S)-5-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethyloct-7en-3-one (2S)-5-benzyloxy-2-methyl-1-pentanal (3S,6R,7S,8S)-11-(benzyloxy)-3,7-bis{[(tert-butyl)dimethylsilyl]oxy}-4,4,6,8-tetramethyl-5-oxoundecanoic acid methyl ester 12,13-bismethylene-12,13-secoepothilone (4S,7R,8S,9S,16S)-4,8-bis-(tert-butyldimethylsilanyloxy)-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-vinyl]-(13Z)-1-oxacyclohexadec-13-ene-2,6-dione (S)-5-((tert-butyldimethylsilyl)oxy)-4,4-dimethyl-7-((triethylsilyl)oxy)heptan-3-one (3S,6R,7S,8S)-3,7-bis{[(tert-butyl)dimethylsilyl]oxy}-11-hydroxy-4,4,6,8-tetramethyl-5-oxoundecanoic acid methyl ester (5S)-5-hydroxy-4,4-dimethyloct-7en-3-one (3S)-3-(tert-butyl-dimethyl-silanyloxy)-4,4-dimethyl-5-oxo-heptanal (S)-1-methanesulfonyloxy-5-(tert-butyldimethylsilyloxy)-4-methyl-pentane (5S)-5-{[(tert-butyl)dimethylsilyl]oxy}-7-hydroxy-4,4-dimethylheptan-3-one (3S,6R,7S,8S)-11-(benzyloxy)-3,7-bis{[(tert-butyl)dimethylsilyl]oxy}-4,4,6,8-tetramethyl-5-oxoundecanoic acid (3S,6R,7S,8S)-11-(benzyloxy)-3,7-bis{[(tert-butyl)dimethylsilyl]oxy}-hydroxy-4,4,6,8-tetramethylundecan-5-one (3S,6R,7S,8S)-11-(benzyloxy)-3,7-bis{[(tert-butyl)dimethylsilyl]oxy}-4,4,6,8-tetramethyl-5-oxoundecanal (3S,6R,7S,8S)-11-(benzyloxy)-1,3,7-trihydroxy-4,4,6,8-tetramethylundecan-5-one (3S,6R,7S,8S)-11-(benzyloxy)-1,3,7-tris{[(tert-butyl)dimethylsilyl]oxy}-4,4,6,8-tetramethylundecan-5-one (3S,6R,7S,8S)-3,7-bis{[(tert-butyl)dimethylsilyl]oxy}-4,4,6,8-tetramethyl-5-oxoundec-10-enoic acid methyl ester (1S)-1-[(E)-1-Methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-3-butenyl (3S,6R,7S,8S)-3,7-di-[tert-butyldimethylsilyloxy]-4,4,6,8-tetramethyl-5-oxo-12-tridecenoate (3S,6R,7S,8S)-3,7-Di-(tert-butyldimethylsilyloxy)-1-hydroxy-4,4,6,8-tetramethyl-12-tridecen-5-one (4R,5S,6S)-9-(benzyloxy)-2-[(4S)-2,2-dimethyl-1,3-dioxan-4-yl]-5-hydroxy-2,4,6-trimethylnonan-3-one