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雷美替胺

雷美替胺

CAS号：196597-26-9

英文名：N-[2-[(8S)-2,6,7,8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide

分子式

C16H21NO2

熔点

113-115ºC

密度

1.119g/cm3

分子量

259.343

沸点

455.3ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Ramelteon, marketed as Rozerem by Takeda Pharmaceuticals North America, is a sleep agent that selectively binds to the MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN), instead of binding to GABAA receptors, such as with drugs like zolpidem.

基本信息

中文名称

雷美替胺

英文名称

N-[2-[(8S)-2,6,7,8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide

中文别名

雷美尔通、(S)-N-[2-(1,6,7,8-四氢-2H-茚并[5,4-b]呋喃-8-基)乙基]丙酰胺

英文别名

UNII-901AS54I69、Rozerem (TN)、Rozerem、Ramelteon、Ramelteon [USAN]、Rozerem(TM)、[14C]-Ramelteon、(S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]propionamide、TAK-375

CAS号

196597-26-9

分子式

C16H21NO2

分子量

259.343

精确质量

259.157

PSA

38.33

LOGP

2.9585

编号系统

MDL号

MFCD08067736

物化性质

外观与性状

结晶固体

密度

1.119g/cm3

沸点

455.3ºC at 760 mmHg

熔点

113-115ºC

闪点

229.2ºC

折射率

1.555

蒸汽压

1.77E-08mmHg at 25°C

合成路线

(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-ylacetonitrile

(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-ylacetonitrile

丙酸酐

雷美替胺

上游原料

共找到40个上游原料 >

(S)-2-(2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)ethanol

(S)-2-(2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)ethanol

(S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl methanesulfonate

(S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl methanesulfonate

(S)-N-[2-(6-allyloxy-5-bromo-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide

(S)-N-[2-(6-allyloxy-5-bromo-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide

(S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)acetamide

(S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)acetamide

(S)-N-[2-[7-烯丙基-5-溴-2,3-二氢-6-羟基-1H-茚-1-基]乙基]丙酰胺

(S)-N-[2-[7-烯丙基-5-溴-2,3-二氢-6-羟基-1H-茚-1-基]乙基]丙酰胺

丙酸酐

上游原料

(S)-2-(2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)ethanol (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl methanesulfonate (S)-N-[2-(6-allyloxy-5-bromo-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)acetamide (S)-N-[2-[7-烯丙基-5-溴-2,3-二氢-6-羟基-1H-茚-1-基]乙基]丙酰胺丙酸酐 (E)-ethyl 3-(5-(1-(S)-((tert-butylsulfinyl)imino)ethyl)-2,3-dihydrobenzofuran-4-yl) acrylate (E)-N-[2-(2,3-二氢-6-甲氧基-1H-茚-1-亚基)乙基]丙酰胺 (S)-N-[2-(5-bromo-6-hydroxy-7-(2-hydroxyethyl)-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide 3-碘苯酚 (E)-ethyl 3-(5-acetyl-2,3-dihydrobenzofuran-4-yl)acrylate (S)-N-[2-[2,3-二氢-6-羟基-7-(2-羟基乙基)-1H-茚-1-基]乙基]丙酰胺 (S)-N-[2-(5-bromo-6-methoxy-2,3-dihydro-1H-inden-1-yl)ethyl]propionamide (E)-ethyl 3-(5-(2-methyl-1,3-dioxolan-2-yl)-2,3-dihydrobenzofuran-4-yl) acrylate (S)-N-[2-(5-溴-2,3-二氢-6-羟基-1H-茚-1-基)乙基]丙酰胺 (E)-(1,6,7,8-四氢-2H-茚并[5,4-b]呋喃-8-亚基)乙腈乙基溴化镁 1,2,6,7-四氢-8H-茚并[5,4-b]呋喃-8-酮 (8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-ylacetonitrile 甲烷磺酰氯 (S)-dimethyl 2-(2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)malonate (S)-2-(2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)acetic acid 6-甲氧基-1-茚酮 (S)-dimethyl 2-(6-oxo-2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)malonate (S)-3-(2,3-dihydrobenzofuran-4-yl)-5-methoxy-4-(methoxycarbonyl)-5-oxopentanoic acid (2E)-2-(2,3-二氢-6-甲氧基-1H-茚-1-亚基)乙胺 (S)-2-(1,6,7,8,-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine (S)-dimethyl 2-(1-(2,3-dihydrobenzofuran-4-yl)-3-oxopropyl)malonate (2E)-2-(2,3-二氢-6-甲氧基-1H-茚-1-亚基)乙腈 1-(2-bromoethoxy)-3-iodobenzene (E)-3-(2,3-dihydrobenzofuran-4-yl)acrylaldehyde 2-(4-(2-bromoethoxy)-2-iodophenyl)-2-methyl-1,3-dioxolane (S)-ethyl 2-(6-oxo-2,6,7,8-tetrahydro-1H-indeno[5,4-b] furan-8-yl)acetate ethyl 2-((8S)-6-(((S)-tert-butylsulfinyl)imino)-2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)acetate 4-(2-bromoethoxy)-1-(1,1-dimethoxyethyl)-2-iodobenzene 1-(4-(2-bromoethoxy)-2-iodophenyl)ethanone (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)acetyl chloride (S)-ethyl 2-(2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)acetate 3-氨基苯酚 2-(1,6-Dihydro-2H-indeno[5,4-b]furan-8-yl)acetamide