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(3S,5R,6S,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6,8-tetramethyl-undec-10-enoic acid tert-butyl ester

(3S,5R,6S,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6,8-tetramethyl-undec-10-enoic acid tert-butyl ester

CAS号：197233-28-6

英文名：(3S,5R,6S,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6,8-tetramethyl-undec-10-enoic acid tert-butyl ester

分子式：C31H64O5Si2

分子量：573.008

合成路线

(1R,3S,4S,5R,6R)-3-((S)-2-Benzyloxy-1-methyl-ethyl)-4,6-dimethyl-2-oxa-bicyclo[4.1.0]heptan-5-ol

(1R,3S,4S,5R,6R)-3-((S)-2-Benzyloxy-1-methyl-ethyl)-4,6-dimethyl-2-oxa-bicyclo[4.1.0]heptan-5-ol

(3S,5R,6S,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6,8-tetramethyl-undec-10-enoic acid tert-butyl ester

(3S,5R,6S,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6,8-tetramethyl-undec-10-enoic acid tert-butyl ester

(2S,3S,4R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-[1,3]dithian-2-yl-2,4,6-trimethyl-5-triphenylsilanyloxy-heptan-1-ol

(2S,3S,4R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-[1,3]dithian-2-yl-2,4,6-trimethyl-5-triphenylsilanyloxy-heptan-1-ol

(3S,5R,6S,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6,8-tetramethyl-undec-10-enoic acid tert-butyl ester

(3S,5R,6S,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6,8-tetramethyl-undec-10-enoic acid tert-butyl ester

(4R,5S,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methoxy-3,3,5-trimethyl-tetrahydro-pyran-4-ol

(4R,5S,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methoxy-3,3,5-trimethyl-tetrahydro-pyran-4-ol

(3S,5R,6S,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6,8-tetramethyl-undec-10-enoic acid tert-butyl ester

(3S,5R,6S,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6,8-tetramethyl-undec-10-enoic acid tert-butyl ester

[(4R,5R,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methoxy-3,3,5-trimethyl-tetrahydro-pyran-4-yloxy]-triphenyl-silane

[(4R,5R,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methoxy-3,3,5-trimethyl-tetrahydro-pyran-4-yloxy]-triphenyl-silane

(3S,5R,6S,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6,8-tetramethyl-undec-10-enoic acid tert-butyl ester

(3S,5R,6S,7S,8S)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-4,4,6,8-tetramethyl-undec-10-enoic acid tert-butyl ester

上游原料

[(4R,5R,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methoxy-3,3,5-trimethyl-tetrahydro-pyran-4-yloxy]-triphenyl-silane (2S,3S,4R,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-[1,3]dithian-2-yl-2,4,6-trimethyl-5-triphenylsilanyloxy-heptan-1-ol (1R,3S,4S,5R,6R)-3-((S)-2-Benzyloxy-1-methyl-ethyl)-4,6-dimethyl-2-oxa-bicyclo[4.1.0]heptan-5-ol (4R,5S,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methoxy-3,3,5-trimethyl-tetrahydro-pyran-4-ol

下游产品

西洛他唑埃博霉素C (12Z,16E)-(3S,6R,7S,8S,15S)-15-Acetoxy-3,7-bis-(tert-butyl-dimethyl-silanyloxy)-4,4,6,8,16-pentamethyl-17-(2-methyl-thiazol-4-yl)-5-oxo-heptadeca-12,16-dienoic acid