化合物简介
The epothilones are a novel class of antineoplastic agents possessing antitubulin activity. Epothilone A, B isolated from Sorangium cellulosum was associated with cell cycle arrest at G2/M transition and apoptosis that was resisted with overexpression of β-tubulin and P-glycoprotein in human bladder carcinoma cell.
基本信息
中文名称
西洛他唑
英文名称
(1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-5,7,9,9-tetramethyl-14-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-dione
中文别名
埃博霉素A
英文别名
Epo A、Epothilone A、Epothilones、Epothilon A、epithilone A
CAS号
152044-53-6
分子式
C26H39NO6S
分子量
493.656
精确质量
493.25
PSA
137.49
LOGP
4.0874
物化性质
密度
1.143g/cm3
沸点
683.3ºC at 760 mmHg
熔点
95ºC
闪点
367.1ºC
折射率
1.531
蒸汽压
1.31E-19mmHg at 25°C
上游原料
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