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阿扎那韦

阿扎那韦

CAS号：198904-31-3

英文名：atazanavir

分子式

C38H52N6O7

熔点

207-209ºC

密度

1.178g/cm3

分子量

704.855

沸点

溶解度

信号词

危险品标志

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化合物简介

Atazanavir, sold under the trade name Reyataz, is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV).

基本信息

中文名称

阿扎那韦

英文名称

atazanavir

中文别名

阿扎那韦双硫酸盐

英文别名

Atazanavir、Reyataz、UNII-QZU4H47A3S、methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate、2aqu、Zrivada、[3H]-Atazanavir

CAS号

198904-31-3

分子式

C38H52N6O7

分子量

704.855

精确质量

704.39

PSA

171.22

LOGP

5.7752

编号系统

UNII

QZU4H47A3S

物化性质

外观与性状

结晶固体

密度

1.178g/cm3

熔点

207-209ºC

折射率

1.562

生产方法及用途

用途

艾滋病药。

合成路线

L-Valine, N-(methoxycarbonyl)-3-methyl-, 2-[[4-(2-pyridinyl)phenyl]methyl]hydrazide

L-Valine, N-(methoxycarbonyl)-3-methyl-, 2-[[4-(2-pyridinyl)phenyl]methyl]hydrazide

methyl [(2S)-3,3-dimethyl-1-({(1S)-1-[(2R)-oxiran-2-yl]-2-phenylethyl}amino)-1-oxobutan-2-yl]carbamate

methyl [(2S)-3,3-dimethyl-1-({(1S)-1-[(2R)-oxiran-2-yl]-2-phenylethyl}amino)-1-oxobutan-2-yl]carbamate

阿扎那韦

上游原料

共找到29个上游原料 >

(2S,3R)-2-amino-4-chloro-1-phenylbutan-3-ol hydrochloride

(2S,3R)-2-amino-4-chloro-1-phenylbutan-3-ol hydrochloride

1-[4-(pyridine-2-yl)-phenyl]-4(S)-hydroxy-2-N-tert-butoxycarbonylamino-5(S)-N-(N-methoxycarbonyl-(L)-tert-leucyl)amino-6-phenyl-2-azahexane

1-[4-(pyridine-2-yl)-phenyl]-4(S)-hydroxy-2-N-tert-butoxycarbonylamino-5(S)-N-(N-methoxycarbonyl-(L)-tert-leucyl)amino-6-phenyl-2-azahexane

L-Valine, N-(methoxycarbonyl)-3-methyl-, 2-[[4-(2-pyridinyl)phenyl]methyl]hydrazide

L-Valine, N-(methoxycarbonyl)-3-methyl-, 2-[[4-(2-pyridinyl)phenyl]methyl]hydrazide

4-(2-吡啶基)-苯甲醛

4-(2-吡啶基)-苯甲醛

{(S)-1-[N'-((2S,3S)-3-amino-2-hydroxy-4-phenyl-butyl)-N'-(4-pyridin-2-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester

{(S)-1-[N'-((2S,3S)-3-amino-2-hydroxy-4-phenyl-butyl)-N'-(4-pyridin-2-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester

methyl [(2S)-3,3-dimethyl-1-({(1S)-1-[(2R)-oxiran-2-yl]-2-phenylethyl}amino)-1-oxobutan-2-yl]carbamate

methyl [(2S)-3,3-dimethyl-1-({(1S)-1-[(2R)-oxiran-2-yl]-2-phenylethyl}amino)-1-oxobutan-2-yl]carbamate

上游原料

(2S,3R)-2-amino-4-chloro-1-phenylbutan-3-ol hydrochloride 1-[4-(pyridine-2-yl)-phenyl]-4(S)-hydroxy-2-N-tert-butoxycarbonylamino-5(S)-N-(N-methoxycarbonyl-(L)-tert-leucyl)amino-6-phenyl-2-azahexane L-Valine, N-(methoxycarbonyl)-3-methyl-, 2-[[4-(2-pyridinyl)phenyl]methyl]hydrazide 4-(2-吡啶基)-苯甲醛 {(S)-1-[N'-((2S,3S)-3-amino-2-hydroxy-4-phenyl-butyl)-N'-(4-pyridin-2-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester methyl [(2S)-3,3-dimethyl-1-({(1S)-1-[(2R)-oxiran-2-yl]-2-phenylethyl}amino)-1-oxobutan-2-yl]carbamate (1S)-1-(2R)-环氧乙基-2-苯乙基氨基甲酸叔丁酯 2-(4-dimethoxymethylphenyl)pyridine L-叔亮氨酸 {(1S,2S)-1-benzyl-2-hydroxy-3-[N'-((S)-2-methoxycarbonylamino-3,3-dimethyl-butyryl)-N-(4-pyridin-2-yl-benzyl)-hydrazino]-propyl}-carbamic acid tert-butyl ester Tert-butyl 2-{(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}hydrazinecarboxylate 4-溴苯甲醛 N-(methoxycarbonyl)-L-tert-leucinyl hydrazine hydrochloride 1-(4-(吡啶-2-基)苄基)肼氯甲酸甲酯 4-溴苯甲醛二甲缩醛 2-甲基-2-丙基(2E)-2-[4-(2-吡啶基)亚苄基]肼羧酸酯 (6S,7S)-7-benzyl-2,2,3,3,11,11-hexamethyl-9-oxo-4,10-dioxa-8-aza-3-siladodecan-6-yl methanesulfonate N-甲氧羰基-L-叔亮氨酸 2-[[4-(2-吡啶基)苯基]甲基]-肼羧酸-(1,1-二甲基)乙酯 2-甲基-2-丙基(3,4-二羟基-1-苯基-2-丁烷基)氨基甲酸酯 (2R,3S)-3-(叔丁氧羰基氨基)-1-氯-2-羟基-4-苯基丁烷 [[4-(2-吡啶基)苯基]亚甲基]-肼羧酸叔丁酯 N-[N-(methoxycarbonyl)-L-tert-leucinyl]-N'-[4-(2-pyridyl)phenylmethylidene]hydrazine 邻溴吡啶 (3S)-3-(叔丁氧羰基)氨基-1-氯-4-苯基-2-丁酮 methyl ((S)-1-(((2S,3S)-4-(2-((S)-2-amino-3,3-dimethylbutanoyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-yl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate 1-[4-(吡啶-2-基)苯基]-5(S)-2,5-双 [(叔丁基氧基羰基)–氨基]-4(S)-羟基l-6-苯基-2-氮杂己烷 4-甲酰基苯硼酸