百科

1-[(2R,4R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(2-imidazol-1-yl-2-oxo-ethyl)-tetrahydro-furan-2-yl]-5-methyl-3-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

1-[(2R,4R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(2-imidazol-1-yl-2-oxo-ethyl)-tetrahydro-furan-2-yl]-5-methyl-3-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

CAS号：202724-76-3

英文名：1-[(2R,4R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(2-imidazol-1-yl-2-oxo-ethyl)-tetrahydro-furan-2-yl]-5-methyl-3-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

分子式：C27H46N4O6Si2

分子量：578.848

合成路线

1-[(2R,4S,5S)-4-Allyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-3-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

1-[(2R,4S,5S)-4-Allyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-3-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

1-[(2R,4R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(2-imidazol-1-yl-2-oxo-ethyl)-tetrahydro-furan-2-yl]-5-methyl-3-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

1-[(2R,4R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(2-imidazol-1-yl-2-oxo-ethyl)-tetrahydro-furan-2-yl]-5-methyl-3-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

{(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[5-methyl-2,4-dioxo-3-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl}-acetaldehyde

{(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[5-methyl-2,4-dioxo-3-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl}-acetaldehyde

1-[(2R,4R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(2-imidazol-1-yl-2-oxo-ethyl)-tetrahydro-furan-2-yl]-5-methyl-3-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

1-[(2R,4R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(2-imidazol-1-yl-2-oxo-ethyl)-tetrahydro-furan-2-yl]-5-methyl-3-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione

上游原料

1-[(2R,4S,5S)-4-Allyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-3-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione {(2S,3R,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[5-methyl-2,4-dioxo-3-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl}-acetaldehyde

下游产品

(2R,3S,5R)-2-(4-((2S,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3-((2-(trimethylsilyl)ethoxy)methyl)-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)-3-oxobutyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl acetate 5'-{3-[(3'R)-5'-(4,4'-Dimethoxytrityl)-3'-deoxythymidin-3'-yl]-2-oxopropyl}-5'-deoxythymidine 3'-O-Acetyl-5'-{3-[(3'R)-5'-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-yl]-2-oxopropyl}-5'-deoxythymidine 2-Cyanoethyl {5'-[3-((3'R)-3'-deoxythymidin-3'-yl)-2-oxopropyl]-5'-deoxythymidin-3'-yl}(3'-acetylthymidin-5'-O-yl)phosphinate