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11-羟基他波宁

11-羟基他波宁

CAS号：22149-28-6

英文名：Methyl (5α,12β,19α)-16-hydroxy-2,3,6,7-tetradehydroaspidospermidi ne-3-carboxylate

分子式

C21H24N2O3

熔点

密度

分子量

352.427

沸点

溶解度

信号词

危险品标志

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化合物简介

16-Hydroxytabersonine is a terpene indole alkaloid produced by the plant Catharanthus roseus. The metabolite is an intermediate in the formation of vindoline, a precursor needed for formation of the pharmaceutically valuable vinblastine and vincristine. 16-hydroxytabersonine is formed from the hydroxylation of tabersonine by tabersonine 16-hydroxylase (T16H). Tabersonine 16-O-methyltransferase (16OMT) methylates the hydroxylated 16 position to form 16-methoxytabersonine.

基本信息

中文名称

11-羟基他波宁

英文名称

Methyl (5α,12β,19α)-16-hydroxy-2,3,6,7-tetradehydroaspidospermidi ne-3-carboxylate

中文别名

英文别名

11-hydroxytabersonine、9-Octadecenoic acid,11-hydroxy、11-hydroxyoleic acid

CAS号

22149-28-6

分子式

C21H24N2O3

分子量

352.427

精确质量

352.179

PSA

61.8

LOGP

3.0027

合成路线

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(-)-11-Mesyloxytabersonine

(-)-11-Mesyloxytabersonine

11-羟基他波宁

11-羟基他波宁

上游原料

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4-氨基苯酚甲磺酸酯

4-氨基苯酚甲磺酸酯

(E)-3-(2-isocyano-4-((methylsulfonyl)oxy)phenyl)allyl acetate

(E)-3-(2-isocyano-4-((methylsulfonyl)oxy)phenyl)allyl acetate

Methanesulfonic acid 4-amino-3-nitro-phenyl ester

Methanesulfonic acid 4-amino-3-nitro-phenyl ester

4-iodo-3-nitrophenyl methanesulfonate

4-iodo-3-nitrophenyl methanesulfonate

tert-butyl 3-(2-acetoxyethyl)-2-iodo-6-((methylsulfonyl)oxy)-1H-indole-1-carboxylate

tert-butyl 3-(2-acetoxyethyl)-2-iodo-6-((methylsulfonyl)oxy)-1H-indole-1-carboxylate

(5R,7S,12R,19S)-2,3-didehydro-7-hydroxy-16-[(methanesulfonyl)oxy]aspidospermidine-3-carboxylic acid methyl ester

(5R,7S,12R,19S)-2,3-didehydro-7-hydroxy-16-[(methanesulfonyl)oxy]aspidospermidine-3-carboxylic acid methyl ester

下游产品

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脱乙酰基文多灵

脱乙酰基文多灵

文多灵

上游原料

4-氨基苯酚甲磺酸酯 (E)-3-(2-isocyano-4-((methylsulfonyl)oxy)phenyl)allyl acetate Methanesulfonic acid 4-amino-3-nitro-phenyl ester 4-iodo-3-nitrophenyl methanesulfonate tert-butyl 3-(2-acetoxyethyl)-2-iodo-6-((methylsulfonyl)oxy)-1H-indole-1-carboxylate (5R,7S,12R,19S)-2,3-didehydro-7-hydroxy-16-[(methanesulfonyl)oxy]aspidospermidine-3-carboxylic acid methyl ester methyl 2-(3-(2-((N-(((2S)-4-ethyl-5-hydroxytetrahydrofuran-2-yl)methyl)-2,4-dinitrophenyl)sulfonamido)ethyl)-6-((methylsulfonyl)oxy)-1H-indol-2-yl)acrylate 对硝基苯基甲烷磺酸酯 (-)-11-Mesyloxytabersonine (E)-3-nitro-4-(3-oxoprop-1-en-1-yl)phenyl methanesulfonate 4'-甲基磺酰乙酰苯胺 (E)-3-(4-((methylsulfonyl)oxy)-2-nitrophenyl)allyl acetate (E)-3-(2-formamido-4-((methylsulfonyl)oxy)phenyl)allyl acetate 3-(2-hydroxyethyl)-6-methanesulfonyloxy-2-(1-methoxycarbonylvinyl)indole-1-carboxylic acid tert-butyl ester 1-[tert-butoxycarbonyl]-3-[2-[[(2,4-dinitrophenyl)sulfonyl][[(2S)-4-ethyl-2,3-dihydro-2-furanyl]methyl]amino]ethyl]-α-methylene-6-[(methanesulfonyl)oxy]-1H-indole-2-acetic acid methyl ester 4-acetamido-3-nitrophenyl methanesulfonate methyl 2-(3-(2-((((2S)-4-ethyl-5-hydroxytetrahydrofuran-2-yl)methyl)amino)ethyl)-6-((methylsulfonyl)oxy)-1H-indol-2-yl)acrylate

下游产品

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