化合物简介
Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. It was developed by Merck Sharp & Dohme in 1971 after showing promise in a research project studying more potent chemical analogs of aspirin. It was first sold under the brand name Dolobid, marketed by Merck & Co., but generic versions are now widely available. It is classed as a non-steroidal anti-inflammatory drug (NSAID) and is available in 250mg and 500mg tablets.
基本信息
中文名称
二氟尼柳
英文名称
Diflunisal
中文别名
5-(2,4-二氟苯基)水杨酸、二氟苯水杨酸、氟苯水杨酸、2\',4\'-二氟-4-羟基-[1,1\'-联苯]-3-羧酸
英文别名
4\',6\'-difluoro-4-hydroxybiphenyl-3-carboxylic acid、5-(2,4-Difluorophenyl)salicylic acid、2-hydroxy-5-(2\',4\'-difluorophenyl)benzoic acid、Dolobis、Dolobid、Flustar、Diflunisalum、5-(2,4-difluorophenyl)-2-hydroxybenzoic acid、Flovacil、Adomal、Fluniget、Fluodonil、2\',4\'-difluoro-4-hydroxy-3-biphenylcarboxylic acid、2\',4\'-difluoro-4-hydroxy-[1,1\'-biphenyl]-3-carboxylic acid
CAS号
22494-42-4
分子式
C13H8F2O3
分子量
250.198
精确质量
250.044
PSA
57.53
LOGP
3.0356
编号系统
MDL号
MFCD00057834
EINECS号
245-034-9
RTECS号
DV2030000
物化性质
外观与性状
白色固体
密度
1.437g/cm3
沸点
249 °C (15 mmHg)
熔点
32-36 °C
闪点
33 °C
折射率
1.601
稳定性
Stable at normal temperatures and pressures.
储存条件
Keep tightly closed. Store in a cool dry place.
蒸汽压
2.75E-07mmHg at 25°C
安全信息
RTECS号
DV2030000
安全说明
S22-S26-S36
危险类别码
R22; R36/37/38; R63
WGK Germany
3
海关编码
2918290000
危险品标志
Xn
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