化合物简介
Methyl Thioglycolate is an derivative of Thioglycolic Acid, an organic compound containing both a thiol and a carboxylic acid functional groups. Thioglycolic Acid and its derivatives are often used in organic synthesis as a nucleophile in thioglycolysis reactions and is also used as a S transfer agent for sulfonyl chloride synthesis. Methyl Thioglycolate have been studied for the its influence on neocarzinostatin activation and expression of DNA damage.
基本信息
中文名称
巯基乙酸甲酯
英文名称
methyl 2-sulfanylacetate
中文别名
硫代乙醇酸甲脂、硫代乙醇酸甲酯
英文别名
methylthioglycolic ester、Thioglycolic Acid Methyl Ester、mercapto acetic acid methylester、2-mercaptoacetic acid methyl ester、USAF EK-7119、Methyl Thioglycolate、methyl mercaptoglycolate、methyl 2-mercaptoacetate、Acetic acid, mercapto-, methyl ester、Methanethiol,methoxy、Acetic acid,mercapto-,methyl ester、Mercaptoacetic Acid Methyl Ester、Methylthioglycolate、Thioglycolic acid methyl ester、Methyl mercaptoacetate、sulfanylacetic acid methyl ester、1-methoxycarbonylmethanethiol
CAS号
2365-48-2
分子式
C3H6O2S
分子量
106.144
精确质量
106.009
PSA
65.1
LOGP
0.0892
编号系统
RTECS号
AI7350000
BRN号
506259
EINECS号
219-121-7
MDL号
MFCD00004873
PubChem号
24846848
物化性质
外观与性状
无色或灰白的绿色液体
密度
1.187g/mLat 25°C(lit.)
沸点
42-43°C10mm Hg(lit.)
熔点
-24 °C
闪点
86°F
折射率
n20/D 1.466(lit.)
水溶解性
40 g/L (20 ºC)
稳定性
Stable under normal temperatures and pressures.
储存条件
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.
蒸汽压
3.58mmHg at 25°C
安全信息
RTECS号
AI7350000
安全说明
S26-S36/37-S45-S36/37/39-S28A
危险类别码
R10; R20/22; R25; R36/37/38
WGK Germany
1
海关编码
29309070
危险品运输编码
UN 1992 3/PG 3
危险类别
3
包装等级
III
危险品标志
T; Xn
危险标志
GHS02, GHS06
信号词
Danger
危险性描述
H226; H301; H315; H319; H332; H335
危险性防范说明
P261; P301 + P310; P305 + P351 + P338
生产方法及用途
生产方法
其制备方法是在反应釜内加入巯基乙酸和甲醇,搅拌,滴加少量浓硫酸为催化剂,滴完,回流反应12h,反应结束后,加入水洗涤至中性,分水,得成品。 HSCH2COOH+CH3OH[H2SO4]→HSCH2COOCH3+H2O
用途
医药及农药中间体。
上游原料
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