百科

阿卡地新

阿卡地新

CAS号：2627-69-2

英文名：AICAR

分子式

C9H14N4O5

熔点

214-215°C

密度

2.06 g/cm3

分子量

258.231

沸点

726.3ºC at 760 mmHg

溶解度

信号词

Warning

危险品标志

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化合物简介

Acadesine (INN), also known as 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, AICA-riboside, and AICAR, is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.

基本信息

中文名称

阿卡地新

英文名称

AICAR

中文别名

5-氨基咪唑-4-甲酰胺盐酸盐、氨鲁米特、阿卡地辛、5-氨基-1-BETA-D-呋喃核糖基-1H-咪唑-4-甲酰胺、5-氨基咪唑-4-甲酰胺-1-Β-D-呋喃核糖苷

英文别名

Acadesine、GP 1-110、ACADESINE、5-Amino-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide、Z-RIBOSIDE、5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside、5-amino-4-imidazole carboxamide ribonucleoside、AIC-Riboside、Acadesine,AICA、Arasine、AMPK、AICA-RIBOSIDE

CAS号

2627-69-2

分子式

C9H14N4O5

分子量

258.231

精确质量

258.096

PSA

156.85

LOGP

-1.5428

编号系统

EINECS号

220-097-5

MDL号

MFCD00869751

PubChem号

24724407

物化性质

外观与性状

固体

密度

2.06 g/cm3

沸点

726.3ºC at 760 mmHg

熔点

214-215°C

闪点

393.1ºC

折射率

1.821

储存条件

-20ºC

蒸汽压

3.83E-22mmHg at 25°C

安全信息

安全说明

S26-S36

WGK Germany

3

危险类别码

R36/37/38

海关编码

2934999090

危险品标志

Xi

危险性防范说明

P261; P305 + P351 + P338

危险性描述

H315; H319; H335

信号词

Warning

危险标志

GHS07

合成路线

共找到16条合成路线 >

9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1-((2-methoxyethoxy)methyl)-1H-purin-6(9H)-one

9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1-((2-methoxyethoxy)methyl)-1H-purin-6(9H)-one

阿卡地新

海关数据

共找到8个国家海关数据 >

国家/地区名称	海关编码	更新时间	操作
中国	2934999090	2019-03	查看
美国	2934999000	2019-03	查看
印度	29349900	2019-03	查看
欧盟	29349990	2019-03	查看
英国	2934999090	2019-03	查看
日本	293499090	2019-03	查看
韩国	2934999000	2019-03	查看
加拿大	2934990090	2019-03	查看

上游原料

共找到29个上游原料 >

5-Amino-1-(β-D-ribofuranosyl)imidazole-4-carboxylic Acid Hydrazide

5-Amino-1-(β-D-ribofuranosyl)imidazole-4-carboxylic Acid Hydrazide

N-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)diaminomaleonoitrile

N-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)diaminomaleonoitrile

5-amino-1-(β-D-ribofuranosyl)imidazole-4-(N-benzyl)carboxamide

5-amino-1-(β-D-ribofuranosyl)imidazole-4-(N-benzyl)carboxamide

1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4,5-dicyanoimidazole

1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4,5-dicyanoimidazole

2’,3’,5’-三乙酰肌苷

2’,3’,5’-三乙酰肌苷

1-(2,4-dinitrophenyl)inosine

1-(2,4-dinitrophenyl)inosine

下游产品

共找到17个下游商品 >

[(2R,3S,4R,5R)-3,4-dihydroxy-5-[2-(methoxymethoxymethyl)-6-oxo-3H-purin-9-yl]oxolan-2-yl]methyl dihydrogen phosphate

[(2R,3S,4R,5R)-3,4-dihydroxy-5-[2-(methoxymethoxymethyl)-6-oxo-3H-purin-9-yl]oxolan-2-yl]methyl dihydrogen phosphate

5-Amino-1-(β-D-ribofuranosyl)imidazole-4-carboxylic Acid Hydrazide

5-Amino-1-(β-D-ribofuranosyl)imidazole-4-carboxylic Acid Hydrazide

巴豆苷

5-碘-1-(2’,3’,5’-三-O-乙酰基-beta-D-呋喃核糖基)-咪唑并-4-甲腈

5-碘-1-(2’,3’,5’-三-O-乙酰基-beta-D-呋喃核糖基)-咪唑并-4-甲腈

5-氨基-4-咪唑甲酰胺

5-氨基-4-咪唑甲酰胺

2-苯基氨基腺苷

2-苯基氨基腺苷

上游原料

5-Amino-1-(β-D-ribofuranosyl)imidazole-4-carboxylic Acid Hydrazide N-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)diaminomaleonoitrile 5-amino-1-(β-D-ribofuranosyl)imidazole-4-(N-benzyl)carboxamide 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4,5-dicyanoimidazole 2’,3’,5’-三乙酰肌苷 1-(2,4-dinitrophenyl)inosine 1-乙酰基-2,3,5-三苯甲酰氧基-1-beta-D-呋喃核糖 1-(2,4-dinitrophenyl)-2',3'-O-isopropylideneinosine 5-azido-1-β-D-ribofuranosyl-1H-imidazole-4-carbonitrile 1-benzyl-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-one 9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1-((2-methoxyethoxy)methyl)-1H-purin-6(9H)-one N-formyl-N'-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)diaminomaleonitrile 肌苷 2',3',5'-tri-O-acetyl-1-[(2-trimethylsilylethoxy)methyl]inosine methyl 4-cyano-1-(β-D-ribofuranosyl)imidazole-5-carboximidate 5-azido-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide 1-methoxy-9-methyl-2-azaadenine hydroiodide 9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1-(methoxymethyl)-1,9-dihydro-6H-purin-6-one 5-amino-N'-methoxy-1-methylimidazole-4-carboxamidine 2,3,5-tri-O-benzoyl-β-D-ribofuranosyl bromide 1-叠氮基-2,3,5-三苯甲酰氧基-beta-D-呋喃核糖 5-amino-1-(5'-O-tert-butyldimethylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)imidazole-4-carboxamide 2',3',5'-tri-O-acetyl-1-[(ethoxy)methyl]inosine 5-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carbonitrile 2',3',5'-tri-O-acetyl-1-[(2-methoxyethoxy)methyl]inosine 2',3',5'-tri-O-acetyl-1-[(benzyloxy)methyl]inosine 2',3',5'-tri-O-acetyl-1-[(methoxy)methyl]inosine

下游产品

[(2R,3S,4R,5R)-3,4-dihydroxy-5-[2-(methoxymethoxymethyl)-6-oxo-3H-purin-9-yl]oxolan-2-yl]methyl dihydrogen phosphate 5-Amino-1-(β-D-ribofuranosyl)imidazole-4-carboxylic Acid Hydrazide 巴豆苷 5-碘-1-(2’,3’,5’-三-O-乙酰基-beta-D-呋喃核糖基)-咪唑并-4-甲腈 5-氨基-4-咪唑甲酰胺 2-苯基氨基腺苷咪唑立宾 N2-甲基鸟苷 5-amino-1-(2,3,5-tris-O-acetyl-β-D-ribofuranosyl)-1H-imidazole-4-carboxylic acid 鸟苷 5-氨基-1-(2-O,3-O,5-O-三乙酰基-beta-D-呋喃核糖基)-1H-咪唑-4-甲酰胺 1-氨基肌苷 5-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carbonitrile N2-苯甲酰基-D-鸟苷 5-氨基-1-[4-羟基-5-(羟基甲基)四氢呋喃-2-基]咪唑-4-甲酰胺 5-氨基咪唑-4-甲酰胺-1-β-D-呋喃核糖苷5-磷酸盐